GPR84 - G protein-coupled receptor 84 Gene

Also Known as EX33; GPCR4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 53831

About GPR84

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:54,350,698-54,364,486 (from NCBI)

This gene has 2 transcripts (splice variants), 124 orthologues and 25 paralogues. Biased expression in bone marrow (RPKM 5.7), appendix (RPKM 3.3) and 6 other tissues.

Summary

Predicted to enable urotensin II receptor activity. Predicted to be involved in neuropeptide signaling pathway. Part of receptor complex. [provided by Alliance of Genome Resources, Apr 2022]

GPR84 Products (3)

mRNA Protein Name
XM_011538495.3 XP_011536797.1 G-protein coupled receptor 84 isoform X1
XM_047429017.1 XP_047284973.1 G-protein coupled receptor 84 isoform X2
NM_020370.3 NP_065103.1 G-protein coupled receptor 84

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
Cellular Component GO Annotation Evidence References Source
part of receptor complex IDA
IDA: Inferred from direct assay
23382219 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPR84 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (37 - 370)

  • 0
  • 100
  • 200
  • 300
  • 396 a.a.
Protein Preferred Names Protein Names

G-protein coupled receptor 84

  • inflammation-related G protein-coupled receptor EX33

GPR84 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GPR84 Q9NQS5 CERS6 Homo sapiens Q6ZMG9
Anti Tag CoIP
33961781
Intra
GPR84 Q9NQS5 CERS6 Homo sapiens Q6ZMG9
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

GPR84 Antibodies

Cat. No. Product Name Application Reactivity
HY-P86697 GPR84 Antibody (YA6389) WB Human

Related Diseases

Diseases Alias
Alzheimer Disease 14

  • AD14

  • Alzheimer'S Disease 14

  • Alzheimer Disease-14

  • Alzheimer'S Disease 14, Late Onset
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-100775 Fezagepras sodium Antagonist 99.81% Phase 3
HY-135303 GLPG1205 Antagonist 99.94% Phase 2

Pre-clinical Phase

Bioactive Molecules (23)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-12764 6-OAU Agonist 99.77% Unkown
HY-112562 GPR84 antagonist 8 Antagonist 99.93% Unkown
HY-100775A Fezagepras Antagonist 99.38% Yes
HY-151100 GPR84 antagonist 3 Antagonist 98.32% Unkown
HY-124571 ZQ-16 Agonist 99.0% Unkown
HY-161106 OX04528 Agonist 98.45% Unkown
HY-145697 GPR84 antagonist 2 Antagonist 99.06% Unkown
HY-163350 TUG-2208 Agonist 98.09% Unkown
HY-126346 DL-175 Agonist 99.0% Unkown
HY-178234 LY237 Agonist 99.96% Unkown
HY-139675 GPR84 antagonist 1 Antagonist 98.56% Unkown
HY-173556 GPR84 agonist-2 Agonist 99.80% Unkown
HY-176039 TUG-2181 Antagonist 98.20% Unkown
HY-W182770 GPR84 agonist-1 Agonist / Unkown
HY-163349 TUG-2099 Inhibitor / Unkown
HY-180488 GPR84 antagonist 10 Antagonist / Unkown
HY-179471 PSB-17365 Agonist / Unkown
HY-161107 OX04529 Agonist / Unkown
HY-161682 GPR84 antagonist 9 Antagonist / Unkown
HY-182723 PSB-16671 Activator / Unkown
HY-167754 Resolvin D5 n-3 DPA Agonist / Unkown
HY-182921 GPR84 antagonist 11 Antagonist / Unkown
HY-17669 PSB-16434 Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus GPR84 VGNC VGNC:67444
Macaca mulatta GPR84 VGNC VGNC:73146
Canis familiaris GPR84 VGNC VGNC:41446
Mus musculus GPR84 MGD MGI:1934129
Bos taurus GPR84 VGNC VGNC:29601
Rattus norvegicus GPR84 RGD RGD:1585277
Others GPR84 NCBI