PPIC - peptidylprolyl isomerase C Gene

Also Known as CYPC

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5480

About PPIC

Cytogenetic location: 5q23.2 Genomic coordinates (GRCh38): 5:123,023,250-123,036,725 (from NCBI)

This gene has 2 transcripts (splice variants), 199 orthologues and 22 paralogues. Ubiquitous expression in thyroid (RPKM 32.1), placenta (RPKM 29.0) and 24 other tissues.

Summary

The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase)) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. Similar to Other PPIases, this protein can bind immunosuppressant cyclosporin A. [provided by RefSeq, Jul 2008]

PPIC Products (1)

mRNA Protein Name
NM_000943.5 NP_000934.1 peptidyl-prolyl cis-trans isomerase C precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables peptidyl-prolyl cis-trans isomerase activity IDA
IDA: Inferred from direct assay
20676357 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPIC Protein Structure

Pro_isomerase

Pro_isomerase: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD (43 - 195)

  • 0
  • 100
  • 200
  • 212 a.a.
Protein Preferred Names Protein Names

peptidyl-prolyl cis-trans isomerase C

  • PPIase C

PPIC Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PPIC P45877 UBQLN1 Homo sapiens Q9UMX0-2
Y2H Array
25416956
Intra
PPIC P45877 UBQLN1 Homo sapiens Q9UMX0-2
Y2H Prey Pooling
25416956
Intra
PPIC P45877 BANP Homo sapiens Q8N9N5-2
Y2H Prey Pooling
32296183
Intra
PPIC P45877 BANP Homo sapiens Q8N9N5-2
Validated Y2H
32296183
Intra
PPIC P45877 BANP Homo sapiens Q8N9N5-2
Y2H Array
32296183
Intra
PPIC P45877 CAPNS2 Homo sapiens Q96L46
Validated Y2H
32296183
Intra
PPIC P45877 CAPNS2 Homo sapiens Q96L46
Y2H Prey Pooling
32296183
Intra
PPIC P45877 CAPNS2 Homo sapiens Q96L46
Y2H Array
32296183
Intra
PPIC P45877 FAM25C Homo sapiens B3EWG5
Y2H Prey Pooling
32296183
Intra
PPIC P45877 FAM25C Homo sapiens B3EWG5
Y2H Array
32296183
Intra
PPIC P45877 SGTA Homo sapiens O43765
Validated Y2H
25416956
Intra
PPIC P45877 SGTA Homo sapiens O43765
Y2H Prey Pooling
32296183
Intra
PPIC P45877 SGTA Homo sapiens O43765
Y2H Array
25416956
Intra
PPIC P45877 SGTA Homo sapiens O43765
Y2H Array
32296183
Intra
PPIC P45877 SGTB Homo sapiens Q96EQ0
Y2H Prey Pooling
32296183
Intra
PPIC P45877 SGTB Homo sapiens Q96EQ0
Validated Y2H
32296183
Intra
PPIC P45877 SGTB Homo sapiens Q96EQ0
Y2H Array
32296183
Intra
PPIC P45877 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
Intra
PPIC P45877 UBQLN2 Homo sapiens Q9UHD9
Y2H Array
32296183
Intra
PPIC P45877 UBQLN2 Homo sapiens Q9UHD9
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PPIC Proteins

Cat. No. Product Name Accession Purity
HY-P71223 PPIC Protein, Human (Trx-His) P45877 (K31-D182) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Disseminated Intravascular Coagulation

  • Defibrination Syndrome

  • Dic

  • Diffuse Or Disseminated Intravascular Coagulation

  • Fibrinolytic Purpura

  • Consumption Coagulopathy

  • Diffuse Intravascular Coagulation

  • Dic - [Disseminated Intravascular Coagulation]

  • Disseminated Intravascular Coagulopathy

  • Fibrinolysis Nos

  • Thrombolytic Purpura
Fish Allergy

  • Allergy To Fish
Crab Allergy

  • Green Mud Crab Allergy

  • Scylla Paramamosain Allergy
Post-Cardiac Arrest Syndrome

  • Post Cardiac Syndrome
Thrombotic Thrombocytopenic Purpura

  • Purpura, Thrombotic Thrombocytopenic

  • Ttp

  • Thrombotic Thrombocytopenic Purpura, Acquired

  • Idiopathic Thrombotic Thrombocytopenic Purpura

  • Moschcowitz Disease

  • Moschcowitz'S Syndrome

  • Moschowitz Syndrome

  • Chronic Relapsing Thrombotic Thrombocytopenic Purpura

  • Familial Thrombotic Thrombocytopenia Purpura

  • Moschkowitz Disease

  • Purpura Thrombotic Thrombocytopenic

  • Familial Thrombotic Thrombocytopenic Purpura

  • Microangiopathic Hemolytic Anemia

  • Congenital Thrombotic Thrombocytopenic Purpura

  • Autoimmune Thrombotic Thrombocytopenic Purpura

  • Ttp - [Thrombotic Thrombocytopenic Purpura]

  • Moschcowitz Syndrome
Chicken Egg Allergy

  • Gallus Gallus Egg Allergy
Apple Allergy

  • Malus Domestica Fruit Allergy
Alkhurma Hemorrhagic Fever

  • Alkhumra Haemorrhagic Fever
Melon Allergy

  • Cucumis Melo Fruit Allergy
Peach Allergy

  • Prunus Persica Fruit Allergy
Vegetable Allergy
Kyasanur Forest Disease

  • Kfd

  • Monkey Fever

  • Kfd Virus

  • Kyasanur Hemorrhagic Fever

  • Monkey Disease

  • Monkey Diseases

  • Kfd - [ Kyasanur Forest Disease]

  • Monkey Sickness
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10948 PPIC Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20799 Ppic Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27313 Ppic Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PPIC RGD RGD:1303221
Mus musculus PPIC MGD MGI:97751
Canis familiaris PPIC VGNC VGNC:44850
Felis catus PPIC VGNC VGNC:97562
Bos taurus PPIC VGNC VGNC:33196
Macaca mulatta PPIC VGNC VGNC:81508
Others PPIC NCBI