MED9 - mediator complex subunit 9 Gene

Also Known as MED25

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55090

About MED9

Cytogenetic location: 17p11.2 Genomic coordinates (GRCh38): 17:17,477,000-17,493,221 (from NCBI)

This gene has 5 transcripts (splice variants) and 203 orthologues. Ubiquitous expression in heart (RPKM 9.0), brain (RPKM 7.1) and 25 other tissues.

Summary

The multiprotein Mediator complex is a coactivator required for activation of RNA polymerase II transcription by DNA bound transcription factors. The protein encoded by this gene is thought to be a subunit of the Mediator complex. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]

MED9 Products (1)

mRNA Protein Name
NM_018019.3 NP_060489.1 mediator of RNA polymerase II transcription subunit 9

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
14638676 GOA
Cellular Component GO Annotation Evidence References Source
part of core mediator complex IPI
IPI: Inferred from physical interaction
24882805 GOA
located in nucleus IDA
IDA: Inferred from direct assay
24882805 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MED9 Protein Structure

Med9

Med9: RNA polymerase II transcription mediator complex subunit 9 (63 - 140)

  • 0
  • 100
  • 146 a.a.
Protein Preferred Names Protein Names

mediator of RNA polymerase II transcription subunit 9

  • mediator of RNA polymerase II transcription, subunit 9 homolog

MED9 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MED9 Q9NWA0 MED4 Homo sapiens Q9NPJ6
Anti Tag CoIP
15175163
Intra
MED9 Q9NWA0 MED4 Homo sapiens Q9NPJ6
Anti Tag CoIP
14638676
Intra
MED9 Q9NWA0 MED4 Homo sapiens Q9NPJ6
Anti Tag CoIP
24882805
Intra
MED9 Q9NWA0 MED4 Homo sapiens Q9NPJ6
Anti Tag CoIP
35271311
Intra
MED9 Q9NWA0 MED4 Homo sapiens Q9NPJ6
Pull Down
14638676
Intra
MED9 Q9NWA0 MED21 Homo sapiens Q13503
Anti Tag CoIP
15175163
Intra
MED9 Q9NWA0 MED21 Homo sapiens Q13503
Anti Tag CoIP
14638676
Intra
MED9 Q9NWA0 MED21 Homo sapiens Q13503
Anti Tag CoIP
35271311
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Smith-Magenis Syndrome

  • SMS

  • Chromosome 17p11.2 Deletion Syndrome

  • 17p11.2 Microdeletion Syndrome

  • 17p11.2 Monosomy

  • Chromosome 17p Deletion Syndrome

  • Del(17)

  • P11.2

  • 17p- Syndrome

  • Deletion 17p Syndrome

  • Partial Monosomy 17p
Jacobsen Syndrome

  • Chromosome 11q Deletion Syndrome

  • Partial 11q Monosomy Syndrome

  • Jacobsen Distal 11q Deletion Syndrome

  • JBS

  • 11q Partial Monosomy Syndrome

  • Chromosome 11q Deletion

  • 11q Deletion

  • 11q Monosomy

  • Deletion 11q

  • Monosomy 11q

  • Partial Monosomy 11q

  • 11q Deletion Disorder

  • 11q Deletion Syndrome

  • 11q Terminal Deletion Disorder

  • 11q- Deletion Syndrome

  • 11q23 Deletion Disorder

  • Jacobsen Thrombocytopenia

  • 11q Terminal Deletion Syndrome

  • Del(11)(Q23.3)

  • Del(11)(Qter)

  • Distal Deletion 11q

  • Distal Monosomy 11q

  • Monosomy 11qter

  • Telomeric Deletion 11q

  • Paris-Trousseau Thrombocytopenia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08307 MED9 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18774 Med9 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25262 Med9 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris MED9 VGNC VGNC:43142
Mus musculus MED9 MGD MGI:2183151
Felis catus MED9 VGNC VGNC:99277
Rattus norvegicus MED9 RGD RGD:1563669
Bos taurus MED9 VGNC VGNC:31370
Macaca mulatta MED9 VGNC VGNC:74577
Others MED9 NCBI