2. Gene
  3. DRAM1 - DNA damage regulated autophagy modulator 1 Gene

DRAM1 - DNA damage regulated autophagy modulator 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as DRAM

Gene ID: 55332 | Gene type: protein coding

About DRAM1

Cytogenetic location: 12q23.2 Genomic coordinates (GRCh38): 12:101,877,580-101,923,612 (from NCBI)

This gene has 7 transcripts (splice variants), 215 orthologues and 4 paralogues. Broad expression in lung (RPKM 41.9), urinary bladder (RPKM 12.1) and 20 other tissues.

Summary

This gene is regulated as part of the p53 tumor suppressor pathway. The gene encodes a lysosomal membrane protein that is required for the induction of Autophagy by the pathway. Decreased transcriptional expression of this gene is associated with various tumors. This gene has a pseudogene on chromosome 4. [provided by RefSeq, Jul 2008]

DRAM1 Products(1)

mRNA Protein Name
NM_018370.3 NP_060840.2 DNA damage-regulated autophagy modulator protein 1

DRAM1 Protein Structure

Frag1

Frag1: Frag1/DRAM/Sfk1 family (9 - 225)

  • 0
  • 100
  • 200
  • 238 a.a.
Protein Preferred Names Protein Names

DNA damage-regulated autophagy modulator protein 1

damage-regulated autophagy modulator

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03987 DRAM1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus DRAM1 RGD RGD:1598133
Bos taurus DRAM1 VGNC VGNC:28201
Mus musculus DRAM1 MGD MGI:1918962
Macaca mulatta DRAM1 VGNC VGNC:108339
Canis familiaris DRAM1 VGNC VGNC:40088