DRAM1 - DNA damage regulated autophagy modulator 1 Gene

Also Known as DRAM

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55332

About DRAM1

Cytogenetic location: 12q23.2 Genomic coordinates (GRCh38): 12:101,877,580-101,923,612 (from NCBI)

This gene has 7 transcripts (splice variants), 215 orthologues and 4 paralogues. Broad expression in lung (RPKM 41.9), urinary bladder (RPKM 12.1) and 20 other tissues.

Summary

This gene is regulated as part of the p53 tumor suppressor pathway. The gene encodes a lysosomal membrane protein that is required for the induction of Autophagy by the pathway. Decreased transcriptional expression of this gene is associated with various tumors. This gene has a pseudogene on chromosome 4. [provided by RefSeq, Jul 2008]

DRAM1 Products (1)

mRNA Protein Name
NM_018370.3 NP_060840.2 DNA damage-regulated autophagy modulator protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
involved in regulation of autophagy IDA
IDA: Inferred from direct assay
19895784 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
19895784 GOA
located in lysosome IDA
IDA: Inferred from direct assay
19895784 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DRAM1 Protein Structure

Frag1

Frag1: Frag1/DRAM/Sfk1 family (9 - 225)

  • 0
  • 100
  • 200
  • 238 a.a.
Protein Preferred Names Protein Names

DNA damage-regulated autophagy modulator protein 1

  • damage-regulated autophagy modulator

DRAM1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
DRAM1 Q8N682 C1orf21 Homo sapiens Q9H246
Y2H Prey Pooling
25416956
Intra
DRAM1 Q8N682 CD164L2 Homo sapiens Q6UWJ8-2
Y2H Prey Pooling
32296183
Intra
DRAM1 Q8N682 CD164L2 Homo sapiens Q6UWJ8-2
Y2H Array
32296183
Intra
DRAM1 Q8N682 CLRN1 Homo sapiens P58418
Y2H Array
32296183
Intra
DRAM1 Q8N682 CLRN1 Homo sapiens P58418
Y2H Prey Pooling
32296183
Intra
DRAM1 Q8N682 EVI2B Homo sapiens P34910-2
Y2H Prey Pooling
32296183
Intra
DRAM1 Q8N682 EVI2B Homo sapiens P34910-2
Y2H Array
32296183
Intra
DRAM1 Q8N682 GPR42 Homo sapiens O15529
Y2H Prey Pooling
32296183
Intra
DRAM1 Q8N682 GPR42 Homo sapiens O15529
Y2H Array
32296183
Intra
DRAM1 Q8N682 LRRC4C Homo sapiens Q9HCJ2
Y2H Prey Pooling
32296183
Intra
DRAM1 Q8N682 LRRC4C Homo sapiens Q9HCJ2
Validated Y2H
32296183
Intra
DRAM1 Q8N682 LRRC4C Homo sapiens Q9HCJ2
Y2H Array
32296183
Intra
DRAM1 Q8N682 TIMMDC1 Homo sapiens Q9NPL8
Y2H Array
32296183
Intra
DRAM1 Q8N682 TIMMDC1 Homo sapiens Q9NPL8
Validated Y2H
32296183
Intra
DRAM1 Q8N682 TIMMDC1 Homo sapiens Q9NPL8
Y2H Prey Pooling
32296183
Intra
DRAM1 Q8N682 MS4A7 Homo sapiens Q9GZW8
Validated Y2H
32296183
Intra
DRAM1 Q8N682 MS4A7 Homo sapiens Q9GZW8
Y2H Prey Pooling
32296183
Intra
DRAM1 Q8N682 MS4A7 Homo sapiens Q9GZW8
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

DRAM1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P89894 DRAM Antibody (YA9238) WB, ICC/IF, IF-Tissue, IP human

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03987 DRAM1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21559 Dram1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28077 Dram1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus DRAM1 RGD RGD:1598133
Bos taurus DRAM1 VGNC VGNC:28201
Mus musculus DRAM1 MGD MGI:1918962
Macaca mulatta DRAM1 VGNC VGNC:108339
Canis familiaris DRAM1 VGNC VGNC:40088
Others DRAM1 NCBI