GPRC5D - G protein-coupled receptor class C group 5 member D Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55507

About GPRC5D

Cytogenetic location: 12p13.1 Genomic coordinates (GRCh38): 12:12,940,575-12,952,170 (from NCBI)

This gene has 2 transcripts (splice variants), 197 orthologues and 3 paralogues. Low expression observed in reference dataset.

Summary

The protein encoded by this gene is a member of the G protein-coupled receptor family; however, the specific function of this gene has not yet been determined. [provided by RefSeq, Jul 2008]

GPRC5D Products (1)

mRNA Protein Name
NM_018654.2 NP_061124.1 G-protein coupled receptor family C group 5 member D

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPRC5D Protein Structure

7tm_3

7tm_3: 7 transmembrane sweet-taste receptor of 3 GCPR (33 - 265)

  • 0
  • 100
  • 200
  • 300
  • 345 a.a.
Protein Preferred Names Protein Names

G-protein coupled receptor family C group 5 member D

  • orphan G-protein coupled receptor

GPRC5D Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GPRC5D Q9NZD1 LRRC25 Homo sapiens Q8N386
Y2H Array
32296183
Intra
GPRC5D Q9NZD1 LRRC25 Homo sapiens Q8N386
Y2H Prey Pooling
32296183
Intra
GPRC5D Q9NZD1 LHFPL5 Homo sapiens Q8TAF8
Y2H Prey Pooling
32296183
Intra
GPRC5D Q9NZD1 PVR Homo sapiens P15151
Y2H Array
32296183
Intra
GPRC5D Q9NZD1 PVR Homo sapiens P15151
Y2H Prey Pooling
32296183
Intra
GPRC5D Q9NZD1 SYNDIG1 Homo sapiens Q9H7V2
Y2H Prey Pooling
32296183
Intra
GPRC5D Q9NZD1 SYNDIG1 Homo sapiens Q9H7V2
Y2H Array
32296183
Intra
GPRC5D Q9NZD1 YIPF1 Homo sapiens Q9Y548
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant GPRC5D Proteins

Cat. No. Product Name Accession Purity
HY-P77958 GPRC5D Protein-VLP, Human (HEK293) Q9NZD1-1 (M1-V345) ≥ 95%, as determined by HPLC.
HY-P77959 GPRC5D Protein-VLP, Human (Biotinylated, HEK293) Q9NZD1-1 (Y2-V345) ≥ 95%, as determined by HPLC.
HY-P700457 GPRC5D Protein-VLP, Human (HEK293, C-His) Q9NZD1-1 (M1-V345) Purity analysis by SDS-PAGE is not available for VLP proteins.

GPRC5D Antibodies

Cat. No. Product Name Application Reactivity
HY-P811151 GPRC5D Antibody WB, ICC/IF Human, Mouse, Rat
HY-P81701 GPRC5D Antibody (YA1446) FC, ELISA Human

Related Diseases

Diseases Alias
Smoldering Myeloma
Keratopathy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P99394 Talquetamab 96.44% Unkown

Clinical Phase

Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P991055 Forimtamig Inhibitor 99.96% Phase 2
HY-P991587 SAR-446523 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-171754 LM-305 97.00% Unkown
HY-RS05752 GPRC5D Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17133 Gprc5d Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23579 Gprc5d Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991197 Anti-GPRC5D Antibody Inhibitor 99.9% Unkown
HY-P991155 Ramantamig Inhibitor 95% Unkown
HY-P991726 Vemzatatug Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris GPRC5D VGNC VGNC:41451
Felis catus GPRC5D VGNC VGNC:62695
Macaca mulatta GPRC5D VGNC VGNC:72935
Bos taurus GPRC5D VGNC VGNC:29608
Mus musculus GPRC5D MGD MGI:1935037
Rattus norvegicus GPRC5D RGD RGD:1563887
Others GPRC5D NCBI