IL17RB - interleukin 17 receptor B Gene

Also Known as CRL4; EVI27; IL17BR; IL17RH1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55540

About IL17RB

Cytogenetic location: 3p21.1 Genomic coordinates (GRCh38): 3:53,846,568-53,865,794 (from NCBI)

This gene has 3 transcripts (splice variants), 142 orthologues and 4 paralogues. Broad expression in kidney (RPKM 18.0), liver (RPKM 7.7) and 21 other tissues.

Summary

The protein encoded by this gene is a cytokine receptor. This receptor specifically binds to IL17B and IL17E, but does not bind to IL17 and IL17C. This receptor has been shown to mediate the activation of NF-kappaB and the production of IL8 induced by IL17E. The expression of the rat counterpart of this gene was found to be significantly up-regulated during intestinal inflammation, which suggested the immunoregulatory activity of this receptor. [provided by RefSeq, Jul 2008]

IL17RB Products (1)

mRNA Protein Name
NM_018725.4 NP_061195.2 interleukin-17 receptor B precursor

IL17RB Protein Structure

SEFIR

SEFIR: SEFIR domain (333 - 479)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 502 a.a.
Protein Preferred Names Protein Names

interleukin-17 receptor B

  • IL-17 receptor B

IL17RB Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
IL17RB Q9NRM6 DAZAP2 Homo sapiens Q15038
Y2H
22070932
Intra
IL17RB Q9NRM6 DAZAP2 Homo sapiens Q15038
Pull Down
22070932
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IL17RB Proteins

Cat. No. Product Name Accession Purity
HY-P72581 IL-17RB Protein, Human (HEK293, His) Q9NRM6-1 (R18-G289) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P76419 IL-17RB Protein, Human (HEK293, Fc) Q9NRM6-1 (R18-G289) ≥ 85%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Herpes Zoster

  • Shingles

  • Zoster

  • Herpes Zona

  • Herpes Zoster Disease

  • Zona Zoster

  • Herpes Zoster Of Skin And Mucous Membranes

  • Zoster Nos

  • Zoster With Nervous System Involvement
Parasitic Helminthiasis Infectious Disease

  • Helminthiasis

  • Intestinal Helminthiasis

  • Helminth Infection

  • Helminthosis

  • Worm Infection

  • Worm Infections

  • Helminth Infections

  • Intestinal Infection Due To Class Cestoda And/Or Class Trematoda And/Or Phylum Nemata

  • Parasitic Enteritis

  • Metazoal Dysentery

  • Intestinal Worms Nos
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P991266 SM-17 Inhibitor 96.98% Phase 2

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06703 IL17RB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991710 Ponumkibart Inhibitor 95.48% Unkown
HY-P992237 Anti-IL-17RB Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris IL17RB VGNC VGNC:41947
Mus musculus IL17RB MGD MGI:1355292
Rattus norvegicus IL17RB RGD RGD:1311392
Felis catus IL17RB VGNC VGNC:62902
Macaca mulatta IL17RB VGNC VGNC:73618
Others IL17RB NCBI