IL17RB - interleukin 17 receptor B Gene

Homo sapiens

Also known as CRL4; EVI27; IL17BR; IL17RH1

Gene ID: 55540 | Gene type: protein coding

About IL17RB

Cytogenetic location: 3p21.1 Genomic coordinates (GRCh38): 3:53,846,568-53,865,794 (from NCBI)

This gene has 3 transcripts (splice variants), 142 orthologues and 4 paralogues. Broad expression in kidney (RPKM 18.0), liver (RPKM 7.7) and 21 other tissues.

Summary

The protein encoded by this gene is a cytokine receptor. This receptor specifically binds to IL17B and IL17E, but does not bind to IL17 and IL17C. This receptor has been shown to mediate the activation of NF-kappaB and the production of IL8 induced by IL17E. The expression of the rat counterpart of this gene was found to be significantly up-regulated during intestinal inflammation, which suggested the immunoregulatory activity of this receptor. [provided by RefSeq, Jul 2008]

IL17RB Products(1)

mRNA	Protein	Name
NM_018725.4	NP_061195.2	interleukin-17 receptor B precursor

IL17RB Protein Structure

SEFIR

0
100
200
300
400
502 a.a.

Protein Preferred Names

Protein Names

interleukin-17 receptor B

IL-17 receptor B

Recombinant IL17RB Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72581	IL-17RB Protein, Human (272a.a, HEK293, His)	Q9NRM6 (R18-G289)	≥95%
HY-P76419	IL-17RB Protein, Human (HEK293, Fc)	Q9NRM6 (M1-G289)	≥95%
HY-P76420	IL-17RB Protein, Human (289a.a, HEK293, His)	Q9NRM6 (M1-G289)	≥95%

Related Diseases

Diseases

Alias

Herpes Zoster

Shingles	Zoster
Herpes Zona	Herpes Zoster Disease
Zona Zoster	Herpes Zoster Of Skin And Mucous Membranes
Zoster Nos	Zoster With Nervous System Involvement

Parasitic Helminthiasis Infectious Disease

Helminthiasis	Intestinal Helminthiasis
Helminth Infection	Helminthosis
Worm Infection	Worm Infections
Helminth Infections	Intestinal Infection Due To Class Cestoda And/Or Class Trematoda And/Or Phylum Nemata
Parasitic Enteritis	Metazoal Dysentery
Intestinal Worms Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06703	IL17RB Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	IL17RB	VGNC	VGNC:41947
Mus musculus	IL17RB	MGD	MGI:1355292
Rattus norvegicus	IL17RB	RGD	RGD:1311392
Felis catus	IL17RB	VGNC	VGNC:62902
Macaca mulatta	IL17RB	VGNC	VGNC:73618

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