Adam17 - ADAM metallopeptidase domain 17 Gene

Also Known as TACE

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 57027

About Adam17

Primary_assembly 6: 40,872,856-40,920,639 reverse strand.mRatBN7.2:CM026979.1

This gene has 2 transcripts (splice variants), 283 orthologues, 29 paralogues and is associated with 19 phenotypes. Biased expression in Lung (RPKM 343.7), Thymus (RPKM 194.) and 9 other tissues.

Summary

Predicted to enable PDZ domain binding activity; metalloendopeptidase activity involved in amyloid precursor protein catabolic process; and signaling receptor binding activity. Involved in several processes, including regulation of apoptotic process; regulation of signal transduction; and response to antineoplastic agent. Located in several cellular components, including apical part of cell; cell surface; and cytoplasmic vesicle. Biomarker of Alzheimer's disease; congestive heart failure; and thoracic aortic aneurysm. Human ortholog(s) of this gene implicated in Alzheimer's disease; inflammatory bowel disease; and type 2 diabetes mellitus. Orthologous to human ADAM17 (ADAM metallopeptidase domain 17). [provided by Alliance of Genome Resources, Apr 2022]

Adam17 Products (1)

mRNA	Protein	Name
NM_020306.3	NP_064702.2	disintegrin and metalloproteinase domain-containing protein 17 precursor

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to mechanical stimulus	IEP IEP: Inferred from expression pattern	25820551	RGD
involved in membrane protein ectodomain proteolysis	IMP IMP: Inferred from mutant phenotype	15284022	RGD
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	11973430	RGD
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	23688779	RGD
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	21503882	RGD
involved in positive regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	21645559	RGD
involved in response to antineoplastic agent	IEP IEP: Inferred from expression pattern	21503882	RGD
involved in response to hypobaric hypoxia	IEP IEP: Inferred from expression pattern	22230263	RGD
involved in response to muscle activity	IEP IEP: Inferred from expression pattern	25820551	RGD
involved in response to nutrient levels	IEP IEP: Inferred from expression pattern	25820551	RGD
involved in spermatogenesis	IEP IEP: Inferred from expression pattern	25053185	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in apical part of cell	IDA IDA: Inferred from direct assay	25232008	RGD
located in cell surface	IDA IDA: Inferred from direct assay	21503882	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Adam17 Protein Structure

Pep_M12B_propep

ZnMc_TACE_like

DISIN

ADAM17_MPD

0
200
400
600
827 a.a.

Protein Preferred Names	Protein Names
disintegrin and metalloproteinase domain-containing protein 17	ADAM 17 TNF-alpha convertase TNF-alpha-converting enzyme a disintegrin and metallopeptidase domain 17 a disintegrin and metalloprotease domain 17 a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme)

Recombinant Adam17 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72815	ADAM17/TACE Protein, Rat (HEK293, His)	Q9Z1K9 (P18-D563)	≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-10293	Aderbasib	Inhibitor	99.44%	Phase 2

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-115670	GW280264X	Inhibitor	99.30%	Unkown
HY-16657	TAPI-1	Inhibitor	99.36%	Unkown
HY-110397	KP-457	Inhibitor	98.88%	Unkown
HY-120852	JG26	Inhibitor	98.14%	Unkown
HY-P3722A	Mca-PLAQAV-Dpa-RSSSR-NH2 TFA		99.54%	Unkown
HY-P3722	Mca-PLAQAV-Dpa-RSSSR-NH2	Substrate	99.33%	Unkown
HY-175876	ADAM17-IN-1	Inhibitor	/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P992406	MEDI-3622	Inhibitor	/	Unkown
HY-P992341	D8P1C1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Adam17	NCBI	NCBI:6868