CD248 - CD248 molecule Gene

Also Known as TEM1; CD164L1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 57124

About CD248

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:66,314,494-66,317,044 (from NCBI)

This gene has 1 transcript (splice variant), 109 orthologues and 8 paralogues.

Summary

Predicted to enable extracellular matrix binding activity and extracellular matrix protein binding activity. Predicted to be involved in cell migration. Predicted to act upstream of or within several processes, including anatomical structure regression; lymph node development; and positive regulation of endothelial cell apoptotic process. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]

CD248 Products (1)

mRNA	Protein	Name
NM_020404.3	NP_065137.1	endosialin precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CD248 Protein Structure

Lectin_C

FXa_inhibition

EGF_CA

0
200
400
600
757 a.a.

Protein Preferred Names	Protein Names
endosialin	2610111G01Rik

CD248 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CD248	Q9HCU0	LSAMP	Homo sapiens	Q13449	Y2H Array	32814053
Intra	CD248	Q9HCU0	LSAMP	Homo sapiens	Q13449	Validated Y2H	32814053
Intra	CD248	Q9HCU0	LSAMP	Homo sapiens	Q13449	Y2H Pooling	32814053
Intra	CD248	Q9HCU0	ICAM5	Homo sapiens	Q9UMF0	Validated Y2H	32814053
Intra	CD248	Q9HCU0	ICAM5	Homo sapiens	Q9UMF0	Y2H Pooling	32814053
Intra	CD248	Q9HCU0	ICAM5	Homo sapiens	Q9UMF0	Y2H Array	32814053
Intra	CD248	Q9HCU0	MAPK3	Homo sapiens	P27361	Y2H Pooling	32814053
Intra	CD248	Q9HCU0	MAPK3	Homo sapiens	P27361	Validated Y2H	32814053
Intra	CD248	Q9HCU0	MAPK3	Homo sapiens	P27361	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CD248 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P78042	Endosialin/CD248 Protein, Human (HEK293, His)	Q9HCU0-1 (Q18-L687)	≥ 90%, as determined by Bis-Tris PAGE.

CD248 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84811	CD248 Antibody (YA4508)	FC, ELISA	Human
HY-P84811A	CD248 Antibody (YA4508)(PBS only)	WB, FC, ELISA	Human

Related Diseases

Diseases	Alias
Vascular Cancer	Blood Vessel Tumors Malignant Vascular Neoplasm Renal Vein Leiomyosarcoma Vascular Neoplasms Blood Vessel Neoplasm Blood Vessel Tumor Blood Vessel Tumour Disorder Haemangiomatous Tumour Leiomyosarcoma Of The Renal Vein Malignant Great Vessel Tumor Malignant Tumor Of Pulmonary Artery Malignant Tumor Of Pulmonary Vein Malignant Vascular Tumor Neoplasm Of Great Vessel Pulmonary Artery Malignant Neoplasm Pulmonary Vein Malignant Neoplasm Vascular Tissue Neoplasm Vascular Tumors Blood Vessel Cancer Neoplasms, Vascular Tissue Malignant Neoplasm Of Great Vessels
Granulomatous Disease, Chronic, Autosomal Recessive, 3	CGD3 Autosomal Recessive Chronic Granulomatous Disease Cytochrome B-Positive Type Iii Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type 3 Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type Iii Cgd, Autosomal Recessive Cytochrome B-Positive, Type Iii Granulomatous Disease, Chronic, Due To Ncf4 Deficiency Chronic Granulomatous Disease 3, Autosomal Recessive Autosomal Recessive Chronic Granulomatous Disease 3 Autosomal Recessive Cytochrome B-Positive Cgd Type Iii Cdg3 Chronic Granulomatous Disease Due To Ncf4 Deficiency Cgd Autosomal Recessive Cytochrome B-Positive Type Iii Chronic Granulomatous Disease Autosomal Recessive Cytochrome B-Positive Type Iii Granulomatous Disease Chronic Due To Ncf4 Deficiency Granulomatous Disease, Chronic, Autosomal Recessive Cytochrome B-Positive, Type 3
Adult Fibrosarcoma
Urinary Tract Infection	Urinary Tract Infections Uti Urinary Tract Infection Nos Uti - [Urinary Tract Infection] Uti Nos - [Urinary Tract Infection Nos] Urosepsis Nos E Coli Uti E Coli Urinary Tract Infection Escherichia Coli Uti
Epiglottitis	Acute Epiglottitis Acute Epiglottitis And Supraglottitis Acute Epiglottiditis Epiglottiditis Epiglottitis Nos
Sarcoma	Connective And Soft Tissue Neoplasm Tumor Of Soft Tissue And Skeleton Sarcomas Sarcoma - Category
Urethritis	Nonspecific Urethritis Non-Gonococcal Urethritis Nongonococcal Urethritis
Salmonellosis	Salmonella Infections Salmonella Infection

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99778	Ontuxizumab		99.85%	Phase 2

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02215	CD248 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18990	Cd248 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25479	Cd248 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CD248	VGNC	VGNC:70822
Rattus norvegicus	CD248	RGD	RGD:1310404
Felis catus	CD248	VGNC	VGNC:102744
Mus musculus	CD248	MGD	MGI:1917695
Bos taurus	CD248	VGNC	VGNC:27017
Canis familiaris	CD248	VGNC	VGNC:51859
Others	CD248	NCBI