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57409

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11

Inhibitors & Agonists

1

Inhibitory Antibodies

5

Antibodies

8

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-15745A
    PSI-7409 tetrasodium
    5+ Cited Publications

    		 HCV Infection
    PSI-7409 tetrasodium is an active 5'-triphosphate metabolite of sofosbuvir (PSI-7977), inhibiting HCV NS5B polymerases, with IC50s of 1.6, 2.8, 0.7 and 2.6 μM for GT 1b_Con1, GT 2a_JFH1, GT 3a, and GT 4a NS5B polymerases, respectively.
    PSI-7409 tetrasodium
  • HY-15745
    PSI-7409

    		HCV Cancer
    PSI-7409 is the active 5'-triphosphate metabolite of Sofosbuvir (PSI-7977). Sofosbuvir (PSI-7977) is a selective and highly active nucleotide analog inhibitor of HCV.
    PSI-7409
  • HY-114990
    EMD 57439

    		Phosphodiesterase (PDE) Cardiovascular Disease
    EMD 57439 is a selective PDE-III inhibitor. EMD 57439 does not significantly increase c-AMP concentration and has little effect on Ca(50) .
    EMD 57439
  • HY-R03324
    mmu-miR-5709-3p mimic

    		MicroRNA Cancer
    mmu-miR-5709-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
    mmu-miR-5709-3p mimic
    mmu-miR-5709-3p mimic
  • HY-RI03324
    mmu-miR-5709-3p inhibitor

    		MicroRNA Cancer
    mmu-miR-5709-3p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.
    mmu-miR-5709-3p inhibitor
    mmu-miR-5709-3p inhibitor
  • HY-R03325A
    mmu-miR-5709-5p agomir

    		MicroRNA Cancer
    mmu-miR-5709-5p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
    mmu-miR-5709-5p agomir
    mmu-miR-5709-5p agomir
  • HY-RI03325A
    mmu-miR-5709-5p antagomir

    		MicroRNA Cancer
    mmu-miR-5709-5p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
    mmu-miR-5709-5p antagomir
    mmu-miR-5709-5p antagomir
  • HY-R03325
    mmu-miR-5709-5p mimic

    		MicroRNA Cancer
    mmu-miR-5709-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
    mmu-miR-5709-5p mimic
    mmu-miR-5709-5p mimic
  • HY-RI03324A
    mmu-miR-5709-3p antagomir

    		MicroRNA Cancer
    mmu-miR-5709-3p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
    mmu-miR-5709-3p antagomir
    mmu-miR-5709-3p antagomir
  • HY-RI03325
    mmu-miR-5709-5p inhibitor

    		MicroRNA Cancer
    mmu-miR-5709-5p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.
    mmu-miR-5709-5p inhibitor
    mmu-miR-5709-5p inhibitor
  • HY-R03324A
    mmu-miR-5709-3p agomir

    		MicroRNA Cancer
    mmu-miR-5709-3p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
    mmu-miR-5709-3p agomir
    mmu-miR-5709-3p agomir

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