Sh3rf1 - SH3 domain containing ring finger 1 Gene

Also Known as Posh; Sh3md2; 2200003J05Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 59009

Summary

Enables MAP-kinase scaffold activity. Involved in neuron migration; positive regulation of JNK cascade; and regulation of alpha-beta T cell activation. Located in lamellipodium. Is expressed in several structures, including central nervous system and genitourinary system. Orthologous to human SH3RF1 (SH3 domain containing ring finger 1). [provided by Alliance of Genome Resources, Apr 2022]

Sh3rf1 Products (1)

mRNA Protein Name
NM_021506.3 NP_067481.2 E3 ubiquitin-protein ligase SH3RF1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables MAP-kinase scaffold activity IPI
IPI: Inferred from physical interaction
23963642 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16230351 MGI
Biological Process GO Annotation Evidence References Source
involved in neuron migration IMP
IMP: Inferred from mutant phenotype
22959435 MGI
involved in positive regulation of JNK cascade IMP
IMP: Inferred from mutant phenotype
23963642 MGI
involved in regulation of CD4-positive, alpha-beta T cell differentiation IMP
IMP: Inferred from mutant phenotype
27084103 MGI
involved in regulation of CD8-positive, alpha-beta T cell proliferation IMP
IMP: Inferred from mutant phenotype
23963642 MGI
Cellular Component GO Annotation Evidence References Source
located in lamellipodium IDA
IDA: Inferred from direct assay
22959435 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase SH3RF1

  • RING-type E3 ubiquitin transferase SH3RF1

  • SH3 domain-containing RING finger protein 1

  • SH3 multiple domains 2

  • SH3 multiple domains protein 2

  • plenty of SH3 domains

  • plenty of SH3s

  • putative E3 ubiquitin-protein ligase SH3RF1

Sh3rf1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Sh3rf1 Q69ZI1 Bnip3l Mus musculus Q9Z2F7
Anti Tag CoIP
17095503
Intra
Sh3rf1 Q69ZI1 Bnip3l Mus musculus Q9Z2F7
Pull Down
17095503
Cross
Sh3rf1 Q69ZI1 SIAH1 Homo sapiens Q8IUQ4
Anti Tag CoIP
16230351
Cross
Sh3rf1 Q69ZI1 SIAH1 Homo sapiens Q8IUQ4
Pull Down
16230351
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12844 SH3RF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sh3rf1 NCBI NCBI:57630