RBBP4 - RB binding protein 4, chromatin remodeling factor Gene

Also Known as NURF55; RBAP48; lin-53

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5928

About RBBP4

Cytogenetic location: 1p35.1 Genomic coordinates (GRCh38): 1:32,651,208-32,686,211 (from NCBI)

This gene has 19 transcripts (splice variants), 262 orthologues and 9 paralogues. Ubiquitous expression in testis (RPKM 27.2), lymph node (RPKM 20.0) and 25 other tissues.

Summary

This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. It is present in protein complexes involved in histone acetylation and chromatin assembly. It is part of the Mi-2 complex which has been implicated in chromatin remodeling and transcriptional repression associated with histone deacetylation. This encoded protein is also part of co-repressor complexes, which is an integral component of transcriptional silencing. It is found among several cellular proteins that bind directly to retinoblastoma protein to regulate cell proliferation. This protein also seems to be involved in transcriptional repression of E2F-responsive genes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

RBBP4 Products (3)

mRNA	Protein	Name
NM_001135255.2	NP_001128727.1	histone-binding protein RBBP4 isoform b
NM_001135256.2	NP_001128728.1	histone-binding protein RBBP4 isoform c
NM_005610.3	NP_005601.1	histone-binding protein RBBP4 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
contributes to ATP-dependent activity, acting on DNA	IDA IDA: Inferred from direct assay	14609955	GOA
enables histone binding	IDA IDA: Inferred from direct assay	9651585	GOA
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	17827154	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7503932	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA replication-dependent chromatin assembly	IDA IDA: Inferred from direct assay	8858152	GOA
involved in chromatin remodeling	IDA IDA: Inferred from direct assay	9790534	GOA
involved in nucleosome assembly	IDA IDA: Inferred from direct assay	14718166	GOA
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	14609955	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of ATPase complex	IDA IDA: Inferred from direct assay	14609955	GOA
part of CAF-1 complex	IDA IDA: Inferred from direct assay	8858152	GOA
part of CAF-1 complex	IPI IPI: Inferred from physical interaction	9614144	GOA
part of ESC/E(Z) complex	IDA IDA: Inferred from direct assay	20075857	GOA
part of NURF complex	IDA IDA: Inferred from direct assay	20850016	GOA
part of NURF complex	IPI IPI: Inferred from physical interaction	14609955	GOA
part of NuRD complex	IDA IDA: Inferred from direct assay	19644445	GOA
located in chromatin	IDA IDA: Inferred from direct assay	9614144	GOA
located in chromosome, telomeric region	IDA IDA: Inferred from direct assay	30045876	GOA
part of histone deacetylase complex	IDA IDA: Inferred from direct assay	9651585	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	22720776	GOA
located in nucleus	IDA IDA: Inferred from direct assay	14609955	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	14718166	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RBBP4 Protein Structure

CAF1C_H4-bd

WD40

0
100
200
300
400
425 a.a.

Protein Preferred Names	Protein Names
histone-binding protein RBBP4	CAF-1 subunit C

RBBP4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RBBP4	Q09028	q9brl8_human	Homo sapiens	Q9BRL8	Y2H Prey Pooling	25416956
Intra	RBBP4	Q09028	STIP1	Homo sapiens	P31948	Validated Y2H	32814053
Intra	RBBP4	Q09028	STIP1	Homo sapiens	P31948	Y2H Array	32814053
Intra	RBBP4	Q09028	STIP1	Homo sapiens	P31948	Y2H Pooling	32814053
Intra	RBBP4	Q09028	STAT5B	Homo sapiens	P51692	Y2H Array	32296183
Intra	RBBP4	Q09028	STAT5B	Homo sapiens	P51692	Y2H Prey Pooling	32296183
Intra	RBBP4	Q09028	PLP1	Homo sapiens	P60201-2	Y2H Pooling	32814053
Intra	RBBP4	Q09028	PLP1	Homo sapiens	P60201-2	Validated Y2H	32814053
Intra	RBBP4	Q09028	PLP1	Homo sapiens	P60201-2	Y2H Array	32814053
Intra	RBBP4	Q09028	MECOM	Homo sapiens	Q03112	ITC	30462309
Intra	RBBP4	Q09028	MECOM	Homo sapiens	Q03112	Pull Down	30462309
Intra	RBBP4	Q09028	CLSTN1	Homo sapiens	O94985-2	Validated Y2H	32814053
Intra	RBBP4	Q09028	CLSTN1	Homo sapiens	O94985-2	Y2H Array	32814053
Intra	RBBP4	Q09028	CLSTN1	Homo sapiens	O94985-2	Y2H Pooling	32814053
Intra	RBBP4	Q09028	LAMP2	Homo sapiens	P13473-2	Validated Y2H	32814053
Intra	RBBP4	Q09028	LAMP2	Homo sapiens	P13473-2	Y2H Array	32814053
Intra	RBBP4	Q09028	LAMP2	Homo sapiens	P13473-2	Y2H Pooling	32814053
Intra	RBBP4	Q09028	HAT1	Homo sapiens	O14929	Anti Tag CoIP	33961781
Intra	RBBP4	Q09028	HAT1	Homo sapiens	O14929	TAP	24981860
Intra	RBBP4	Q09028	HAT1	Homo sapiens	O14929	Validated Y2H	25416956
Intra	RBBP4	Q09028	SH3GLB1	Homo sapiens	Q9Y371	Y2H Pooling	32814053
Intra	RBBP4	Q09028	SH3GLB1	Homo sapiens	Q9Y371	Validated Y2H	32814053
Intra	RBBP4	Q09028	SH3GLB1	Homo sapiens	Q9Y371	Y2H Array	32814053
Intra	RBBP4	Q09028	PRDM16	Homo sapiens	Q9HAZ2	Pull Down	30462309
Intra	RBBP4	Q09028	PRDM16	Homo sapiens	Q9HAZ2	ITC	30462309
Intra	RBBP4	Q09028	HDAC1	Homo sapiens	Q13547	Anti Tag CoIP	35271311
Intra	RBBP4	Q09028	HDAC1	Homo sapiens	Q13547	Anti Tag CoIP	9150135
Intra	RBBP4	Q09028	HDAC1	Homo sapiens	Q13547	Anti Tag CoIP	33961781
Intra	RBBP4	Q09028	HDAC1	Homo sapiens	Q13547	TAP	27705803
Intra	RBBP4	Q09028	TARDBP	Homo sapiens	Q13148	Validated Y2H	32814053
Intra	RBBP4	Q09028	TARDBP	Homo sapiens	Q13148	Y2H Array	32814053
Intra	RBBP4	Q09028	TARDBP	Homo sapiens	Q13148	Y2H Pooling	32814053
Intra	RBBP4	Q09028	ALDH4A1	Homo sapiens	P30038	Validated Y2H	32814053
Intra	RBBP4	Q09028	ALDH4A1	Homo sapiens	P30038	Y2H Array	32814053
Intra	RBBP4	Q09028	ALDH4A1	Homo sapiens	P30038	Y2H Pooling	32814053
Intra	RBBP4	Q09028	ZFPM1	Homo sapiens	Q8IX07	SPR	21047798
Intra	RBBP4	Q09028	ZFPM1	Homo sapiens	Q8IX07	ITC	21047798
Intra	RBBP4	Q09028	ZFPM1	Homo sapiens	Q8IX07	X-Ray Diffraction	21047798
Intra	RBBP4	Q09028	ZFPM1	Homo sapiens	Q8IX07	Anti Tag CoIP	33961781
Intra	RBBP4	Q09028	HIP1	Homo sapiens	O00291	Validated Y2H	32814053
Intra	RBBP4	Q09028	HIP1	Homo sapiens	O00291	Y2H Pooling	32814053
Intra	RBBP4	Q09028	HIP1	Homo sapiens	O00291	Y2H Array	32814053
Intra	RBBP4	Q09028	MTA1	Homo sapiens	Q13330	Y2H Array	25416956
Intra	RBBP4	Q09028	MTA1	Homo sapiens	Q13330	Y2H Prey Pooling	32296183
Intra	RBBP4	Q09028	MTA1	Homo sapiens	Q13330	Y2H Array	32296183
Intra	RBBP4	Q09028	MTA1	Homo sapiens	Q13330	Y2H Prey Pooling	25416956
Intra	RBBP4	Q09028	MTA1	Homo sapiens	Q13330	Anti Tag CoIP	35271311
Intra	RBBP4	Q09028	MTA1	Homo sapiens	Q13330	TAP	27705803
Intra	RBBP4	Q09028	MTA1	Homo sapiens	Q13330	TAP	24981860
Intra	RBBP4	Q09028	MTA1	Homo sapiens	Q13330	Validated Y2H	32296183
Intra	RBBP4	Q09028	MTA1	Homo sapiens	Q13330	Anti Tag CoIP	33961781
Intra	RBBP4	Q09028	MTA1	Homo sapiens	Q13330	Validated Y2H	25416956
Intra	RBBP4	Q09028	BAG3	Homo sapiens	O95817	Validated Y2H	32814053
Intra	RBBP4	Q09028	BAG3	Homo sapiens	O95817	Y2H Array	32814053
Intra	RBBP4	Q09028	BAG3	Homo sapiens	O95817	Y2H Pooling	32814053
Intra	RBBP4	Q09028	CHRNA7	Homo sapiens	P36544	Y2H Pooling	32814053
Intra	RBBP4	Q09028	CHRNA7	Homo sapiens	P36544	Validated Y2H	32814053
Intra	RBBP4	Q09028	CHRNA7	Homo sapiens	P36544	Y2H Array	32814053
Intra	RBBP4	Q09028	FLNA	Homo sapiens	P21333-2	Y2H Pooling	32814053
Intra	RBBP4	Q09028	FLNA	Homo sapiens	P21333-2	Validated Y2H	32814053
Intra	RBBP4	Q09028	FLNA	Homo sapiens	P21333-2	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant RBBP4 Proteins

Cat. No.	상품명	Accession	Purity
HY-P74601	RBBP4 Protein, Human (sf9, His)	Q09028 (M1-S425)	≥ 85%, as determined by reducing SDS-PAGE.

RBBP4 Antibodies

Cat. No.	상품명	신청	Reactivity
HY-P80301	RBBP4 Antibody (YA103)	WB, ICC/IF, IHC-P, FC, IP	Human, Mouse, Rat
HY-P82098	RBBP4 Antibody (YA1843)	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat, Hamster
HY-P82098A	RBBP4 Antibody (YA1843)(PBS only)	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat, Hamster

Related Diseases

Diseases	Alias
Retinoblastoma	RB Trilateral Retinoblastoma RB1 Retinoblastoma, Trilateral Neuroblastoma Of Retina Rb - Retinoblastoma Eye Cancer, Retinoblastoma Retinal Cancer Retinal Tumor Glioma, Retinal Non-Hereditary Retinoblastoma Childhood Cancer Retinoblastoma Malignant Neoplasm Of Retina Retinal Neoplasms
Hutchinson-Gilford Progeria Syndrome	Progeria HGPS Hutchinson-Gilford Syndrome Hutchinson-Gilford Progeria Hutchinson Gilford Syndrome Hutchinson Gilford Progeria Syndrome Hutchinson-Gilford Disease Progeria Of Childhood Hutchinson-Gilford-Progeria Syndrome
Neuroblastoma	Nb Neuroblastoma, Susceptibility To Neuroblastomas Central Neuroblastoma
Weaver Syndrome	Wss Weaver-Smith Syndrome WVS Weaver-Like Syndrome Weaver-Williams Syndrome Camptodactyly-Overgrowth-Unusual Facies Syndrome Camptodactyly - Overgrowth - Unusual Facies Ezh2 Related Overgrowth Overgrowth Syndrome With Accelerated Skeletal Maturation, Unusual Facies, And Camptodactyly Weaver Smith Syndrome Weaver Like Syndrome Weaver Williams Syndrome Camptodactyly-Overgrowth-Unusual Facies Weaver Syndrome 1 Weaver Syndrome 2 Wvs1 Wvs2
Cockayne Syndrome	Cockayne'S Syndrome Dwarfism-Retinal Atrophy-Deafness Syndrome Neill-Dingwall Syndrome Progeria-Like Syndrome Progeroid Nanism Cs
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-P10600A	BIMAX2 acetate	Inhibitor	98.66%	Unkown
HY-P10598	BIMAX1		/	Unkown
HY-P10600	BIMAX2	Inhibitor	/	Unkown
HY-RS11716	RBBP4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18187	Rbbp4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24661	Rbbp4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RBBP4	RGD	RGD:1593768
Canis familiaris	RBBP4	VGNC	VGNC:45391
Felis catus	RBBP4	VGNC	VGNC:80338
Mus musculus	RBBP4	MGD	MGI:1194912
Bos taurus	RBBP4	VGNC	VGNC:33770
Others	RBBP4	NCBI