Nsf - N-ethylmaleimide sensitive factor, vesicle fusing ATPase Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 60355

Summary

Enables several functions, including ATP hydrolysis activity; ATP-dependent protein binding activity; and signaling receptor binding activity. Involved in several processes, including protein transport; protein-containing complex disassembly; and regulation of vesicle-mediated transport. Located in Golgi stack; dendritic shaft; and postsynaptic density. Biomarker of temporal lobe epilepsy. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy. Orthologous to human NSF (N-ethylmaleimide sensitive factor, vesicle fusing ATPase). [provided by Alliance of Genome Resources, Apr 2022]

Nsf Products (1)

mRNA Protein Name
NM_021748.2 NP_068516.2 vesicle-fusing ATPase

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP hydrolysis activity IDA
IDA: Inferred from direct assay
11062069 RGD
enables ATP-dependent protein binding IPI
IPI: Inferred from physical interaction
11062069 RGD
enables D1 dopamine receptor binding IPI
IPI: Inferred from physical interaction
20623535 RGD
enables ionotropic glutamate receptor binding IPI
IPI: Inferred from physical interaction
12130635 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
9697854 RGD
enables protein serine/threonine kinase binding IPI
IPI: Inferred from physical interaction
20802490 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
11931741 RGD
enables small GTPase binding IPI
IPI: Inferred from physical interaction
11062069 RGD
Biological Process GO Annotation Evidence References Source
involved in positive regulation of receptor-mediated endocytosis IMP
IMP: Inferred from mutant phenotype
21807099 RGD
involved in protein-containing complex disassembly IDA
IDA: Inferred from direct assay
11931741 RGD
involved in regulation of exocytosis IMP
IMP: Inferred from mutant phenotype
11245593 RGD
involved in regulation of receptor internalization IDA
IDA: Inferred from direct assay
11931741 RGD
involved in vesicle-mediated transport IMP
IMP: Inferred from mutant phenotype
11245593 RGD
Cellular Component GO Annotation Evidence References Source
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
11461150 RGD
located in Golgi stack IDA
IDA: Inferred from direct assay
11062069 RGD
located in dendritic shaft IDA
IDA: Inferred from direct assay
1041498 RGD
is active in postsynaptic specialization, intracellular component IDA
IDA: Inferred from direct assay
11461150 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

vesicle-fusing ATPase

  • N-ethylmaleimide-sensitive factor

  • N-ethylmaleimide-sensitive fusion protein

  • NEM-sensitive fusion protein

  • vesicular-fusion protein NSF

Nsf Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Nsf Q9QUL6 Gria2 Rattus norvegicus P19491
Y2H
9697854
Intra
Nsf Q9QUL6 Gria2 Rattus norvegicus P19491
Pull Down
9697854
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09591 NSF Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-P4114 TAT-NSF700scr 95.17% Unkown
HY-P1399A Pep2m, myristoylated TFA Inhibitor 99.77% Unkown
HY-P1057 Pep4c Control / Unkown
HY-P1058 Pep2m Inhibitor / Unkown
HY-P1399 Pep2m, myristoylated Inhibitor / Unkown
HY-P4110 TAT-NSF222 Fusion Peptide Inhibitor / Unkown
HY-118460 ACJI-99C Inhibitor / Unkown
HY-149590 IPA Chemical / Unkown
HY-N12768 Rhodojaponin VI Inhibitor / Unkown
HY-RS16783 Nsf Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23223 Nsf Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nsf NCBI NCBI:4905