Prmt1 - protein arginine methyltransferase 1 Gene

Also Known as Hrmt1l2

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 60421

About Prmt1

Primary_assembly 1: 95,458,850-95,468,345 reverse strand.mRatBN7.2:CM026974.1

This gene has 6 transcripts (splice variants), 190 orthologues, 10 paralogues and is associated with 3 phenotypes. Biased expression in Thymus (RPKM 215.1), Heart (RPKM 24.5) and 9 other tissues.

Summary

Enables identical protein binding activity; protein-arginine N-methyltransferase activity; and snoRNP binding activity. Involved in several processes, including liver regeneration; positive regulation of erythrocyte differentiation; and positive regulation of Hemoglobin biosynthetic process. Acts upstream of or within peptidyl-arginine methylation, to asymmetrical-dimethyl arginine. Located in cytosol; membrane; and nucleus. Part of protein-containing complex. Biomarker of asthma. Orthologous to human PRMT1 (protein arginine methyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]

Prmt1 Products (1)

mRNA	Protein	Name
NM_024363.1	NP_077339.1	protein arginine N-methyltransferase 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables S-adenosyl-L-methionine binding	IDA IDA: Inferred from direct assay	12737817	RGD
enables histone methyltransferase activity	IDA IDA: Inferred from direct assay	8663146	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	9642256	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	10749851	RGD
enables protein methyltransferase activity	IDA IDA: Inferred from direct assay	8663146	RGD
enables protein-arginine N-methyltransferase activity	IDA IDA: Inferred from direct assay	10899106	RGD
enables protein-arginine omega-N asymmetric methyltransferase activity	IDA IDA: Inferred from direct assay	8663146	RGD
enables protein-arginine omega-N monomethyltransferase activity	IDA IDA: Inferred from direct assay	8663146	RGD
enables snoRNP binding	IDA IDA: Inferred from direct assay	12523648	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in S-adenosylmethionine metabolic process	IDA IDA: Inferred from direct assay	12737817	RGD
involved in liver regeneration	IEP IEP: Inferred from expression pattern	15837430	RGD
involved in peptidyl-arginine methylation	IDA IDA: Inferred from direct assay	8663146	RGD
acts upstream of or within peptidyl-arginine methylation, to asymmetrical-dimethyl arginine	IDA IDA: Inferred from direct assay	8663146	RGD
involved in peptidyl-arginine methylation, to asymmetrical-dimethyl arginine	IDA IDA: Inferred from direct assay	8663146	RGD
acts upstream of or within peptidyl-arginine omega-N-methylation	IDA IDA: Inferred from direct assay	8663146	RGD
involved in positive regulation of erythrocyte differentiation	IDA IDA: Inferred from direct assay	23483889	RGD
involved in positive regulation of hemoglobin biosynthetic process	IDA IDA: Inferred from direct assay	23483889	RGD
involved in positive regulation of p38MAPK cascade	IDA IDA: Inferred from direct assay	23483889	RGD
acts upstream of or within protein methylation	IDA IDA: Inferred from direct assay	10749851	RGD
involved in protein methylation	IDA IDA: Inferred from direct assay	23483889	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in cytosol	IDA IDA: Inferred from direct assay	15837430	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	15837430	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Prmt1 Protein Structure

AdoMet_MTases

0
100
200
300
371 a.a.

Protein Preferred Names	Protein Names
protein arginine N-methyltransferase 1	heterogeneous nuclear ribonucleoproteins methyltransferase-like 2 histone-arginine N-methyltransferase PRMT1

Prmt1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Prmt1	Q63009	Prmt1	Rattus norvegicus	Q63009	Y2H	9642256
Intra	Prmt1	Q63009	Prmt1	Rattus norvegicus	Q63009	Anti Tag CoIP	20345902
Intra	Prmt1	Q63009	Btg2	Rattus norvegicus	P27049	Y2H	9642256

Cross: Cross-species interaction Intra: Intraspecies interaction

Prmt1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P86970	Mono-Methyl Arginine (R*GG) Antibody (YA6663)	WB	Species independent

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-128717	GSK3368715	Inhibitor	99.41%	Phase 1

Pre-clinical Phase

Bioactive Molecules (23)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-19615	MS023	Inhibitor	99.93%	Unkown
HY-128717A	GSK3368715 dihydrochloride	Inhibitor	99.96%	Unkown
HY-18962	AMI-1	Inhibitor	98.0%	Unkown
HY-107574	TC-E 5003	Inhibitor	98.06%	Unkown
HY-110137	Furamidine dihydrochloride	Inhibitor	≥99.0%	Unkown
HY-19615B	MS023 dihydrochloride	Inhibitor	99.68%	Unkown
HY-141877	MS4322	Degrader	99.14%	Unkown
HY-122096	DCLX069	Inhibitor	98.03%	Unkown
HY-15890	C-7280948	Inhibitor	99.91%	Unkown
HY-141877B	MS4322 (isomer)		99.87%	Unkown
HY-164456	AMI-408	Inhibitor	/	Unkown
HY-172769	CM112	Degrader	/	Unkown
HY-128717B	GSK3368715 trihydrochloride	Inhibitor	/	Unkown
HY-182297	PRMT1 ligand-1		/	Unkown
HY-161334	CARM1-IN-4	Inhibitor	/	Unkown
HY-149005	PRMT5-IN-19	Inhibitor	/	Unkown
HY-162230	PRMT5-IN-33	Inhibitor	/	Unkown
HY-146810	PRMT4-IN-1	Inhibitor	/	Unkown
HY-184653	MS3-123	Inhibitor	/	Unkown
HY-175821	PRMT1-IN-3	Inhibitor	/	Unkown
HY-186045	SKLB06489	Inhibitor	/	Unkown
HY-182298	PRMT1 ligand-Linker Conjugate 1	Ligand	/	Unkown
HY-W191023	4-Amino-N-(2-phenylethyl)benzamide	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Prmt1	NCBI	NCBI:3276