2. Gene
  3. Prmt1 - protein arginine methyltransferase 1 Gene

Prmt1 - protein arginine methyltransferase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Hrmt1l2

Gene ID: 60421 | Gene type: protein coding

About Prmt1

Primary_assembly 1: 95,458,850-95,468,345 reverse strand.mRatBN7.2:CM026974.1

This gene has 6 transcripts (splice variants), 190 orthologues, 10 paralogues and is associated with 3 phenotypes. Biased expression in Thymus (RPKM 215.1), Heart (RPKM 24.5) and 9 other tissues.

Summary

Enables identical protein binding activity; protein-arginine N-methyltransferase activity; and snoRNP binding activity. Involved in several processes, including liver regeneration; positive regulation of erythrocyte differentiation; and positive regulation of hemoglobin biosynthetic process. Acts upstream of or within peptidyl-arginine methylation, to asymmetrical-dimethyl arginine. Located in cytosol; membrane; and nucleus. Part of protein-containing complex. Biomarker of asthma. Orthologous to human PRMT1 (protein arginine methyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]

Prmt1 Products(1)

mRNA Protein Name
NM_024363.1 NP_077339.1 protein arginine N-methyltransferase 1

Prmt1 Protein Structure

AdoMet_MTases

AdoMet_MTases: cd02440 (91 - 191)

  • 0
  • 100
  • 200
  • 300
  • 371 a.a.
Protein Preferred Names Protein Names

protein arginine N-methyltransferase 1

heterogeneous nuclear ribonucleoproteins methyltransferase-like 2

histone-arginine N-methyltransferase PRMT1

Related Agents

Pre-clinical Phase
Bioactive Molecules (12)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-19615 MS023 Inhibitor 99.73% Unkown
HY-18962 AMI-1 Inhibitor ≥98.0% Unkown
HY-12970A EPZ020411 hydrochloride Inhibitor 98.15% Unkown
HY-12970 EPZ020411 Inhibitor 98.06% Unkown
HY-19615B MS023 dihydrochloride Inhibitor 99.78% Unkown
HY-110137 Furamidine dihydrochloride Inhibitor ≥99.0% Unkown
HY-122096 DCLX069 Inhibitor 98.38% Unkown
HY-128717B GSK3368715 trihydrochloride Inhibitor / Unkown
HY-149005 PRMT5-IN-19 Inhibitor / Unkown
HY-146810 PRMT4-IN-1 Inhibitor / Unkown
HY-162230 PRMT5-IN-33 Inhibitor / Unkown
HY-161334 CARM1-IN-4 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Prmt1 NCBI NCBI:3276