S100P - S100 calcium binding protein P Gene

Also Known as MIG9

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6286

About S100P

Cytogenetic location: 4p16.1 Genomic coordinates (GRCh38): 4:6,693,878-6,697,170 (from NCBI)

This gene has 2 transcripts (splice variants), 131 orthologues and 21 paralogues. Biased expression in stomach (RPKM 580.8), bone marrow (RPKM 258.6) and 4 other tissues.

Summary

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 4p16. This protein, in addition to binding Ca2+, also binds Zn2+ and Mg2+. This protein may play a role in the etiology of prostate Cancer. [provided by RefSeq, Jul 2008]

S100P Products (1)

mRNA Protein Name
NM_005980.3 NP_005971.1 protein S100-P

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium-dependent protein binding IPI
IPI: Inferred from physical interaction
15632002 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11747429 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
11747429 GOA
Biological Process GO Annotation Evidence References Source
involved in endothelial cell migration IMP
IMP: Inferred from mutant phenotype
15313892 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
25468996 GOA
located in nucleus IDA
IDA: Inferred from direct assay
15632002 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

S100P Protein Structure

S_100

S_100: S-100/ICaBP type calcium binding domain (4 - 46)

  • 0
  • 95 a.a.
Protein Preferred Names Protein Names

protein S100-P

  • migration-inducing gene 9 protein

S100P Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
S100P P25815 TGFBI Homo sapiens Q15582
Validated Y2H
32296183
Intra
S100P P25815 TFIP11 Homo sapiens Q9UBB9
Validated Y2H
25416956
Intra
S100P P25815 TFIP11 Homo sapiens Q9UBB9
Y2H Array
25416956
Intra
S100P P25815 S100A1 Homo sapiens Q5T7Y6
BFG-2H
27107012
Intra
S100P P25815 S100A1 Homo sapiens Q5T7Y6
SLC
27107012
Intra
S100P P25815 S100Z Homo sapiens Q8WXG8
Validated Y2H
32296183
Intra
S100P P25815 S100Z Homo sapiens Q8WXG8
Y2H Prey Pooling
32296183
Intra
S100P P25815 S100Z Homo sapiens Q8WXG8
Y2H Array
32296183
Intra
S100P P25815 AGER Homo sapiens Q15109
Anti Bait CoIP
16061848
Intra
S100P P25815 MYH9 Homo sapiens P35579
FPS
31837246
Intra
S100P P25815 CAPZA1 Homo sapiens P52907
FPS
31837246
Intra
S100P P25815 TP53 Homo sapiens P04637
FPS
31837246
Intra
S100P P25815 S100B Homo sapiens P04271
Y2H Prey Pooling
32296183
Intra
S100P P25815 S100B Homo sapiens P04271
Y2H Array
25416956
Intra
S100P P25815 S100B Homo sapiens P04271
Y2H Array
32296183
Intra
S100P P25815 S100B Homo sapiens P04271
Y2H Prey Pooling
25416956
Intra
S100P P25815 HTT Homo sapiens P42858
Validated Y2H
32814053
Intra
S100P P25815 HTT Homo sapiens P42858
Y2H Array
32814053
Intra
S100P P25815 HTT Homo sapiens P42858
Y2H Pooling
32814053
Intra
S100P P25815 NEFL Homo sapiens P07196
Validated Y2H
32814053
Intra
S100P P25815 NEFL Homo sapiens P07196
Y2H Array
32814053
Intra
S100P P25815 NEFL Homo sapiens P07196
Anti Tag CoIP
33961781
Intra
S100P P25815 NEFL Homo sapiens P07196
Y2H Pooling
32814053
Intra
S100P P25815 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra
S100P P25815 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra
S100P P25815 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra
S100P P25815 S100A1 Homo sapiens P23297
FRET
15171681
Intra
S100P P25815 S100A1 Homo sapiens P23297
MAPPIT
25416956
Intra
S100P P25815 S100A1 Homo sapiens P23297
Confocal
15171681
Intra
S100P P25815 TERF2IP Homo sapiens Q9NYB0
Pull Down
21044950
Intra
S100P P25815 TERF2IP Homo sapiens Q9NYB0
BiFC
21044950
Intra
S100P P25815 ARC Homo sapiens Q7LC44
Validated Y2H
32296183
Intra
S100P P25815 ARC Homo sapiens Q7LC44
Y2H Array
32296183
Intra
S100P P25815 ARC Homo sapiens Q7LC44
Y2H Prey Pooling
32296183
Cross
S100P P25815 Cacybp Mus musculus Q9CXW3
Affinity Chrom
12042313
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant S100P Proteins

Cat. No. Product Name Accession Purity
HY-P71138 S100P Protein, Human (His, solution) P25815 (M1-K95) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P71138A S100P Protein, Human (His) P25815 (T2-K95) ≥ 95%, as determined by reducing SDS-PAGE.

S100P Antibodies

Cat. No. Product Name Application Reactivity
HY-P83465 S100P Antibody (YA3210) WB, IHC-P, ICC/IF, IP Human
HY-P86047 S100P Antibody (YA5739) IHC-P, ICC/IF, ELISA Human
HY-P86056 S100P Antibody (YA5748) IHC-P, ICC/IF, ELISA Human

Related Diseases

Diseases Alias
Classic Pulmonary Blastoma

  • Biphasic Pulmonary Blastoma
Endometrial Adenosquamous Carcinoma

  • Adenosquamous Carcinoma Of Endometrium

  • Adenosquamous Carcinoma Of The Endometrium

  • Endometrial Adenosquamous Cancer

  • Endometrial Adenosquamous Cell Carcinoma
Smarca4-Deficient Sarcoma Of Thorax

  • Smarca4-Dts

  • Smarca4-Deficient Thoracic Sarcoma
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Gastric Cancer

  • Stomach Cancer

  • Gastric Carcinoma

  • Stomach Carcinoma

  • Gastric Cancer, Somatic

  • Gastric Neoplasm

  • Carcinoma Of Stomach

  • Stomach Neoplasms

  • Malignant Neoplasm Of Stomach

  • Gastric Cancer Risk After H. Pylori Infection

  • Cancer Of The Stomach

  • Adult Stomach Cancer

  • Adult Stomach Carcinoma

  • GASC

  • Gastric Cancer Intestinal

  • Gastric Cancers

  • Gastric Carcinomas

  • Cancer, Gastric

  • Stomach Neoplasm

  • Malignant Neoplasm Of Body Of Stomach

  • Malignant Tumor Of Lesser Curve Of Stomach

  • Gastrocarcinoma Of Unspecified Site

  • Leather Bottle Stomach

  • Carcinoma Of Fundus Of Stomach

  • Cancer Of Fundus Of Stomach

  • Primary Malignant Neoplasm Of Body Of Stomach

  • Cancer Of Body Of Stomach

  • Primary Malignant Neoplasm Of Pyloric Antrum

  • Pyloric Antrum Cancer

  • Malignant Tumour Of Stomach
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P2268 RAGE antagonist peptide Antagonist 98.16% Unkown
HY-146695 S100P-IN-1 Inhibitor 99.81% Unkown
HY-P2268A RAGE antagonist peptide TFA Antagonist 99.41% Unkown
HY-129085 5-Methyl cromolyn disodium / Unkown
HY-RS12389 S100P Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23418 S100b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown