SAA1 - serum amyloid A1 Gene

Also Known as SAA; PIG4; SAA2; TP53I4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6288

About SAA1

Cytogenetic location: 11p15.1 Genomic coordinates (GRCh38): 11:18,266,264-18,269,967 (from NCBI)

This gene has 5 transcripts (splice variants), 1 gene allele, 140 orthologues, 3 paralogues and is associated with 1 phenotype. Biased expression in fat (RPKM 1382.7), liver (RPKM 1080.1) and 1 other tissue.

Summary

This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and Cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease. This protein may also be a potential biomarker for certain tumors. Finally, antimicrobial activity against S. aureus and E. coli resides in the N-terminal portion of the mature protein. Alternate splicing results in multiple transcript variants that encode the same protein. A pseudogene of this gene is found on chromosome 11. [provided by RefSeq, Jul 2020]

SAA1 Products (3)

mRNA	Protein	Name
NM_000331.6	NP_000322.3	serum amyloid A-1 protein preproprotein
NM_001178006.3	NP_001171477.2	serum amyloid A-1 protein preproprotein
NM_199161.5	NP_954630.2	serum amyloid A-1 protein preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables G protein-coupled receptor binding	IDA IDA: Inferred from direct assay	9892621	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in lymphocyte chemotaxis	IDA IDA: Inferred from direct assay	7636186	GOA
involved in macrophage chemotaxis	IDA IDA: Inferred from direct assay	7561109	GOA
involved in positive regulation of cell adhesion	IDA IDA: Inferred from direct assay	9252455	GOA
involved in positive regulation of cytokine production	IDA IDA: Inferred from direct assay	12857601	GOA
involved in positive regulation of cytosolic calcium ion concentration	IDA IDA: Inferred from direct assay	9892621	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasmic microtubule	IDA IDA: Inferred from direct assay	22131810	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SAA1 Protein Structure

SAA

0
100
122 a.a.

Protein Preferred Names	Protein Names
serum amyloid A-1 protein	serum amyloid A protein

Recombinant SAA1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70510	SAA1 Protein, Human (His)	AAH07022.1 (R19-Y122)	≥ 95%, as determined by reducing SDS-PAGE.

SAA1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81423	Serum Amyloid A Antibody (YA1168)	WB, IHC-P	Human
HY-P84041	SAA1 Antibody (YA3738)	IHC-P, FC, ELISA	Human
HY-P84041A	SAA1 Antibody (YA3738)(PBS only)	IHC-P, FC, ELISA	Human

Related Diseases

Diseases	Alias
Serum Amyloid A Amyloidosis	Aa Amyloidosis Secondary Amyloidosis Reactive Systemic Amyloidosis Apo Serum Amyloid A Amyloidosis Inflammation Aa Amyloidosis Amyloidosis Aa Amyloid A Amyloidosis Inflammatory Amyloidosis Reactive Amyloidosis Amyloidosis Secondary Secondary Systemic Amyloidosis Amyloid Aa
Amyloidosis	Amyloid Disease Amyloid Amyloid Degeneration Amyloidosis Nos Amyloid Deposition Amyloid Infiltration Idiopathic Amyloidosis Hyaloid Degeneration Lardaceous Degeneration
Familial Mediterranean Fever	Periodic Fever Syndrome FMF Benign Paroxysmal Peritonitis Periodic Disease Recurrent Polyserositis Familial Paroxysmal Polyserositis Periodic Fever Familial Mediterranean Fever, Autosomal Recessive Familial Mediterranean Fever, Ar Polyserositis, Recurrent Polyserositis, Familial Paroxysmal Periodic Peritonitis Mef Reimann Periodic Disease Siegal-Cattan-Mamou Disease Wolff Periodic Disease Benign Recurrent Polyserositis Mediterranean Fever, Familial ARFMF Autosomal Recessive Familial Mediterranean Fever Fever, Mediterranean, Familial, Autosomal Recessive Hereditary Autoinflammatory Diseases Fmf - [Familial Mediterranean Fever] Periodic Polyserositis Periodic Familial Polyserositis Periodic Familial Peritonitis Paroxysmal Polyserositis Hereditary Amyloid Nephropathy Familial Recurrent Polyserositis Familial Non-Neuropathic Amyloidosis Armenian Disease Riemann Periodic Disease Siegal Cattan Mamou Disease
Arthritis	Inflammatory Joint Disease Inflammatory Disorder Of Joint
Splenic Artery Aneurysm	Aneurysm Of Splenic Artery
Subclavian Artery Aneurysm	Aneurysm Of Subclavian Artery
Amyloidosis, Familial Visceral	Ostertag Type Amyloidosis German Type Amyloidosis Familial Renal Amyloidosis Amyloidosis Viii Amyloidosis, 3 Or More Types Familial Visceral Amyloidosis Familial Amyloid Nephropathy Hereditary Amyloid Nephropathy Amyloidosis, Familial Renal Amyloidosis, Systemic Nonneuropathic Amyloidosis Familial Visceral Amyloidosis 8 Amyloidosis, Ostertag Type Hereditary Amyloidosis With Primary Renal Involvement Hereditary Renal Amyloidosis Renal Amyloidosis Amyloidosis, Renal Systemic Nonneuropathic Amyloidosis Amyloidosis Familial Renal Amyloidosis Systemic Nonneuropathic Hereditary Amyloidosis With Primary Renal Involement AMYL8 Systemic Non-Neuropathic Amyloidosis Amyloid Nephropathy
Lacrimal Gland Squamous Cell Carcinoma	Epidermoid Carcinoma Of The Lacrimal Gland Squamous Cell Carcinoma Of Lacrimal Gland
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Spondylitis
Crohn'S Disease	Crohn Disease Pediatric Crohn'S Disease Regional Enteritis Crohn'S Disease Of Large Bowel Granulomatous Colitis Enteritis, Granulomatous Enteritis Crohn'S Disease Of Colon Colitis, Granulomatous Crohn'S Enteritis Enteritis, Regional Ileitis Adenoviral Enteritis Acute Gastroenteropathy Due To Norwalk Agent Viral Gastroenteritis Due To Norwalk Agent Winter Vomiting Epidemic Winter Vomiting Disease Small Round Structured Virus Enteritis Epidemic Vomiting Syndrome Epidemic Vomiting Epidemic Nausea Epidemic Viral Gastroenteritis Due To Norwalk Virus Noroviral Enteritis Crohn Disease Nos Crohns Cd - [Crohn'S Disease] Regional Enteritis Of Bowel Crohn'S Regional Enteritis Cobble-Stone Appearance Of Intestine Intestinal Ulcer And Erosion Due To Crohn Disease Granulomatous Enteritis
Amelogenesis Imperfecta, Type If	Amelogenesis Imperfecta Type 1f AI1F Amelogenesis Imperfecta, Hypoplastic Type If Amelogenesis Imperfecta Type If Amelogenesis Imperfecta Hypoplastic Type If Amelogenesis Imperfecta 1f
Lacrimal Gland Mucoepidermoid Carcinoma	Mucoepidermoid Carcinoma Of The Lacrimal Gland
Splenic Disease	Splenic Diseases Dyssplenism Spleen Disease Abnormality Of The Spleen Spleen Diseases
Immunoglobulin Light Chain Amyloidosis	Al Amyloidosis Primary Amyloidosis Primary Systemic Amyloidosis Light Chain Amyloidosis Amyloidosis Al Amyloidosis Primary Systemic Primary Al Amyloidosis Primary Systemic Al Amyloidosis Systemic Al Amyloidsis Systemic Al Amyloidosis Light-Chain Amyloidosis Alys Amyloidosis Familial Amyloid Nephropathy Due To Lysozyme Variant Familial Renal Amyloidosis Due To Lysozyme Variant Hereditary Amyloid Nephropathy Due To Lysozyme Variant Hereditary Renal Amyloidosis Due To Lysozyme Variant Lysozyme Amyloidosis Amyloidosis Primary Immunoglobulin Deposition Disease Immunoglobulinic Amyloidosis Amyloid Al
Rete Ovarii Benign Neoplasm
Rete Ovarii Adenoma	Adenoma Of Rete Ovarii
Polyp Of Corpus Uteri	Endometrial/Uterine Polyp Polyp Of Endometrium Polyp Of The Uterus Polyp, Uterus
Periodic Fever, Familial, Autosomal Dominant	Familial Hibernian Fever Tumor Necrosis Factor Receptor-Associated Periodic Syndrome Traps FPF Tnf Receptor-Associated Periodic Fever Syndrome Hibernian Fever, Familial Fhf Tnf Receptor-Associated Periodic Syndrome Autosomal Dominant Familial Periodic Fever Periodic Fever, Familial Tnf Receptor 1-Associated Periodic Syndrome Tumor Necrosis Factor Receptor 1 Associated Periodic Syndrome Familial Periodic Fever Traps Syndrome Tnf Receptor Associated Periodic Syndrome Caledonian Fever Fever, Periodic, Familial Tumor Necrosis Factor Receptor 1-Associated Periodic Syndrome
Spondyloarthropathy	Spondylarthropathies Spondarthropathy Spondylarthrosis Spondyloarthropathy, Susceptibility To Spondylarthritis
Baastrup'S Syndrome	Kissing Spine Baastrup Syndrome Kissing Spine, Site Unspecified Osteoarthrosis Interspinalis Overriding Of Dorsal Spinous Processes Localised Idiopathic Skeletal Hyperostosis Baastrup Disease
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Myocardial Infarction	Heart Attack Myocardial Infarction, Susceptibility To Myocardial Infarction 1 Myocardial Infarction, Protection Against Myocardial Infarction, Decreased Susceptibility To Myocardial Infarction, Decreased Myocardial Infarct MCI1 Premature Myocardial Infarction Myocardial Infarction, Susceptibility To, Type 1
Salpingitis Isthmica Nodosa
Lipoprotein Quantitative Trait Locus	Coronary Artery Disease Coronary Artery Anomaly Coronary Artery Disease, Susceptibility To Myocardial Ischemia Congenital Anomaly Of Coronary Artery Coronary Arteriosclerosis Coronary Disease Coronary Heart Disease Coronary Artery Disorder LPAQTL Lpa Deficiency, Congenital Coronary Artery Abnormality Coronary Artery Anomaly, Congenital Chd Coronary Syndrome Congenital Malformations Of Coronary Vessels Malformation Of Coronary Vessels Congenital Coronary Artery Anomaly Congenital Coronary Artery Deformity Congenital Coronary Artery Disorder Abnormal Coronary Artery Congenital Coronary Artery Malposition Congenital Coronary Disease Congenital Anomaly Of Coronary Arteries
Diabetes Mellitus	Diabetes
Aplastic Anemia	Aplastic Anemia, Susceptibility To Anemia Aplastic Idiopathic Aplastic Anemia Secondary Aplastic Anemia Idiopathic Bone Marrow Failure Aplastic Anemia Idiopathic AA Anemia, Aplastic Aplastic Anemia, Idiopathic Erythroid Aplasia Aa - [Aplastic Anaemia] Haematopoietic Aplasia Aleukia Haemorrhagica Anaemia Due To Decreased Red Cell Production Aplasia Bone Marrow Aplastic Bone Marrow Hypoplastic Anaemia Nos Myeloid Bone Marrow Aplasia Pancytopenia Panhaematopenia Hypoproliferative Anaemia Medullary Hypoplasia Red Blood Cells Hypoplastic Anaemia Panmyelophthisis Panhemocytopenia Refractive Hypoproliferative Anaemia Toxic Anaemia Toxic Aplastic Anaemia Aplastic Anaemia Due To Toxic Cause Idiopathic Aplastic Anaemia Nos
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Type 2 Diabetes Diabetes Mellitus, Non-Insulin-Dependent T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-122208	SGA360	Inhibitor	99.93%	Unkown
HY-110329	ML179	Agonist	99.73%	Unkown
HY-RS12406	SAA1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS12407	SAA2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16820	Saa1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19640	Saa2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Others	SAA1	NCBI