2. Gene
  3. CCL25 - C-C motif chemokine ligand 25 Gene

CCL25 - C-C motif chemokine ligand 25 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as TECK; Ckb15; SCYA25; TECKvar; Ck beta-15

Gene ID: 6370 | Gene type: protein coding

About CCL25

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:8,052,341-8,062,650 (from NCBI)

This gene has 9 transcripts (splice variants), 59 orthologues and 25 paralogues. Restricted expression toward small intestine (RPKM 203.4).

Summary

This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for dendritic cells, thymocytes, and activated macrophages but is inactive on peripheral blood lymphocytes and neutrophils. The product of this gene binds to Chemokine Receptor CCR9. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]

CCL25 Products(7)

mRNA Protein Name
NM_001201359.2 NP_001188288.1 C-C motif chemokine 25 isoform 2 precursor
NM_001394634.1 NP_001381563.1 C-C motif chemokine 25 isoform 1 precursor
NM_001394635.1 NP_001381564.1 C-C motif chemokine 25 isoform 1 precursor
NM_001394636.1 NP_001381565.1 C-C motif chemokine 25 isoform 1 precursor
NM_001394637.1 NP_001381566.1 C-C motif chemokine 25 isoform 1 precursor
NM_001394638.1 NP_001381567.1 C-C motif chemokine 25 isoform 2 precursor
NM_005624.4 NP_005615.2 C-C motif chemokine 25 isoform 1 precursor

CCL25 Protein Structure

IL8

IL8: Small cytokines (intecrine/chemokine), interleukin-8 like (28 - 90)

  • 0
  • 100
  • 150 a.a.
Protein Preferred Names Protein Names

C-C motif chemokine 25

chemokine (C-C motif) ligand 25

Recombinant CCL25 Proteins

Cat. No. Product Name Accession Purity
HY-P7294 TECK/CCL25 Protein, Human O15444 (Q24-L150) ≥95%

Related Diseases

Diseases Alias
Ileitis

Crohn'S Ileitis
Ascending Cholangitis
Cholangitis, Primary Sclerosing

Primary Sclerosing Cholangitis

PSC

Sclerosing Cholangitis

Cholangitis, Sclerosing

Cholangitis Primary Sclerosing

Psc - [Primary Sclerosing Cholangitis]
Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-15724 Vercirnon Antagonist 98.26% Phase 2
Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-123763 MLN3126 Antagonist 98.64% Unkown
HY-15724A Vercirnon sodium Antagonist 99.13% Unkown
HY-RS02095 CCL25 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CCL25 MGD MGI:1099448
Macaca mulatta CCL25 VGNC VGNC:70700
Rattus norvegicus CCL25 RGD RGD:1305530
Bos taurus CCL25 VGNC VGNC:26951
Canis familiaris CCL25 VGNC VGNC:38887
Others CCL25 NCBI