CCL25 - C-C motif chemokine ligand 25 Gene

Also Known as TECK; Ckb15; SCYA25; TECKvar; Ck beta-15

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6370

About CCL25

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:8,052,341-8,062,650 (from NCBI)

This gene has 9 transcripts (splice variants), 59 orthologues and 25 paralogues. Restricted expression toward small intestine (RPKM 203.4).

Summary

This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for dendritic cells, thymocytes, and activated macrophages but is inactive on peripheral blood lymphocytes and neutrophils. The product of this gene binds to Chemokine Receptor CCR9. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]

CCL25 Products (7)

mRNA	Protein	Name
NM_001201359.2	NP_001188288.1	C-C motif chemokine 25 isoform 2 precursor
NM_001394634.1	NP_001381563.1	C-C motif chemokine 25 isoform 1 precursor
NM_001394635.1	NP_001381564.1	C-C motif chemokine 25 isoform 1 precursor
NM_001394636.1	NP_001381565.1	C-C motif chemokine 25 isoform 1 precursor
NM_001394637.1	NP_001381566.1	C-C motif chemokine 25 isoform 1 precursor
NM_001394638.1	NP_001381567.1	C-C motif chemokine 25 isoform 2 precursor
NM_005624.4	NP_005615.2	C-C motif chemokine 25 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables CCR10 chemokine receptor binding	IDA IDA: Inferred from direct assay	10706668	GOA
enables chemokine activity	IDA IDA: Inferred from direct assay	18308860	GOA
enables chemokine receptor binding	IDA IDA: Inferred from direct assay	23341447	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28381538	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	18308860	GOA
involved in antimicrobial humoral immune response mediated by antimicrobial peptide	IDA IDA: Inferred from direct assay	12949249	GOA
involved in cell chemotaxis	IDA IDA: Inferred from direct assay	18308860	GOA
involved in killing of cells of another organism	IDA IDA: Inferred from direct assay	12949249	GOA
involved in negative regulation of leukocyte tethering or rolling	IDA IDA: Inferred from direct assay	18308860	GOA
involved in positive regulation of cell-matrix adhesion	IDA IDA: Inferred from direct assay	18308860	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CCL25 Protein Structure

IL8

0
100
150 a.a.

Protein Preferred Names	Protein Names
C-C motif chemokine 25	chemokine (C-C motif) ligand 25

CCL25 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CCL25	O15444	PF4V1	Homo sapiens	P10720	Filter Binding	28381538
Intra	CCL25	O15444	CCL17	Homo sapiens	Q92583	SPR	28381538
Intra	CCL25	O15444	CCL17	Homo sapiens	Q92583	Filter Binding	28381538
Intra	CCL25	O15444	PF4	Homo sapiens	P02776	Filter Binding	28381538
Intra	CCL25	O15444	PF4	Homo sapiens	P02776	SPR	28381538
Intra	CCL25	O15444	CCL5	Homo sapiens	P13501	SPR	28381538
Intra	CCL25	O15444	CXCL12	Homo sapiens	P48061	SPR	28381538

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CCL25 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7294	TECK/CCL25 Protein, Human	O15444-1 (Q24-L150)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Ileitis	Crohn'S Ileitis
Ascending Cholangitis
Cholangitis, Primary Sclerosing	Primary Sclerosing Cholangitis PSC Sclerosing Cholangitis Cholangitis, Sclerosing Cholangitis Primary Sclerosing Psc - [Primary Sclerosing Cholangitis]
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-15724	Vercirnon	Antagonist	98.01%	Phase 3
HY-15724A	Vercirnon sodium	Antagonist	98.04%	Phase 2

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-123763	MLN3126	Antagonist	98.02%	Unkown
HY-RS02095	CCL25 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174757	Human CCL25 mRNA		/	Unkown
HY-RS17131	Ccl25 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23576	Ccl25 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991168	Velaprumig	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CCL25	MGD	MGI:1099448
Macaca mulatta	CCL25	VGNC	VGNC:70700
Rattus norvegicus	CCL25	RGD	RGD:1305530
Bos taurus	CCL25	VGNC	VGNC:26951
Canis familiaris	CCL25	VGNC	VGNC:38887
Others	CCL25	NCBI