Pim3 - Pim-3 proto-oncogene, serine/threonine kinase Gene

Rattus norvegicus

Gene ID: 64534 | Gene type: protein coding

About Pim3

Primary_assembly 7: 119,953,175-119,956,587 forward strand.mRatBN7.2:CM026980.1

This gene has 2 transcripts (splice variants), 220 orthologues, 2 paralogues and is associated with 4 phenotypes. Biased expression in Kidney (RPKM 195.9), Heart (RPKM 17.2) and 9 other tissues.

Summary

Enables protein serine/threonine kinase activity. Involved in histone phosphorylation and protein autophosphorylation. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human PIM3 (Pim-3 proto-oncogene, serine/threonine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Pim3 Products(1)

mRNA	Protein	Name
NM_022602.1	NP_072124.1	serine/threonine-protein kinase pim-3

Pim3 Protein Structure

PKc_like

0
100
200
300
326 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein kinase pim-3

kinase induced by depolarization	pim-3 oncogene
protein kinase Kid-1	proviral integration site 3
serine threonine kinase pim3	serine threonine kinase-like

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-101870B	Uzansertib phosphate	Inhibitor	99.39%	Phase 2
HY-19322B	PIM-447 dihydrochloride	Inhibitor	99.94%	Phase 1

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-16976	GDC-0339	Inhibitor	99.77%	Unkown
HY-120758	SEL24-B489	Inhibitor	98.58%	Unkown
HY-111552	PIM1-IN-1	Inhibitor	99.51%	Unkown
HY-122665	HTH-01-091	Inhibitor	98.64%	Unkown
HY-101870	Uzansertib	Inhibitor	/	Unkown
HY-101783	GNE-955	Inhibitor	/	Unkown
HY-123983	HS56	Inhibitor	/	Unkown
HY-163442A	PIM3-IN-1 hydrochloride	Inhibitor	/	Unkown
HY-142696	CDK6/PIM1-IN-1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pim3	NCBI	NCBI:415116

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