Pim3 - Pim-3 proto-oncogene, serine/threonine kinase Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 64534

About Pim3

Primary_assembly 7: 119,953,175-119,956,587 forward strand.mRatBN7.2:CM026980.1

This gene has 2 transcripts (splice variants), 220 orthologues, 2 paralogues and is associated with 4 phenotypes. Biased expression in Kidney (RPKM 195.9), Heart (RPKM 17.2) and 9 other tissues.

Summary

Enables protein serine/threonine kinase activity. Involved in histone phosphorylation and protein autophosphorylation. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human PIM3 (Pim-3 proto-oncogene, serine/threonine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Pim3 Products (1)

mRNA Protein Name
NM_022602.1 NP_072124.1 serine/threonine-protein kinase pim-3

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
9632723 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to forskolin IEP
IEP: Inferred from expression pattern
9632723 RGD
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
9632723 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pim3 Protein Structure

PKc_like

PKc_like: cl21453 (38 - 292)

  • 0
  • 100
  • 200
  • 300
  • 326 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase pim-3

  • kinase induced by depolarization

  • pim-3 oncogene

  • protein kinase Kid-1

  • proviral integration site 3

  • serine threonine kinase pim3

  • serine threonine kinase-like

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-101870B Uzansertib phosphate Inhibitor 99.77% Phase 2
HY-101870 Uzansertib Inhibitor 99.45% Phase 2
HY-19322 PIM447 Inhibitor 99.52% Phase 1
HY-19322B PIM-447 dihydrochloride Inhibitor 99.82% Phase 1

Pre-clinical Phase

Bioactive Molecules (14)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-16976 GDC-0339 Inhibitor 99.87% Unkown
HY-120758 SEL24-B489 Inhibitor 99.02% Unkown
HY-122665 HTH-01-091 Inhibitor 99.81% Unkown
HY-111552 PIM1-IN-1 Inhibitor 99.83% Unkown
HY-164460 AZD1897 Inhibitor 99.69% Unkown
HY-123983 HS56 Inhibitor 99.6% Unkown
HY-142696 CDK6/PIM1-IN-1 Inhibitor / Unkown
HY-101783 GNE-955 Inhibitor / Unkown
HY-186146 SGI-1776-VHL-02 Degrader 96.67% Unkown
HY-181925 FD2024 Inhibitor / Unkown
HY-122670 VS-II-173 Inhibitor / Unkown
HY-N13352 Bufothionine Inhibitor / Unkown
HY-163442A PIM3-IN-1 hydrochloride Inhibitor / Unkown
HY-168479 VB1080 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pim3 NCBI NCBI:415116