Tnik - TRAF2 and NCK interacting kinase Gene

Also Known as 1500031A17Rik; 4831440I19Rik; C530008O15Rik; C630040K21Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 665113

About Tnik

Chromosome 3: 28,317,363-28,730,007 forward strand.GRCm39:CM000996.3

This gene has 18 transcripts (splice variants), 268 orthologues, 35 paralogues and is associated with 20 phenotypes. Broad expression in frontal lobe adult (RPKM 7.4), cortex adult (RPKM 5.7) and 18 other tissues.

Summary

Predicted to enable protein serine/threonine kinase activity. Involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane. Is active in glutamatergic synapse. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human TNIK (TRAF2 and NCK interacting kinase). [provided by Alliance of Genome Resources, Apr 2022]

Tnik Products (4)

mRNA Protein Name
NM_026910.1 NP_081186.1 traf2 and NCK-interacting protein kinase isoform 1
NM_001163009.1 NP_001156481.1 traf2 and NCK-interacting protein kinase isoform 4
NM_001163008.1 NP_001156480.1 traf2 and NCK-interacting protein kinase isoform 3
NM_001163007.1 NP_001156479.1 traf2 and NCK-interacting protein kinase isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
20159449 MGI
Biological Process GO Annotation Evidence References Source
involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IDA
IDA: Inferred from direct assay
23035106 MGI
involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IMP
IMP: Inferred from mutant phenotype
23035106 MGI
Cellular Component GO Annotation Evidence References Source
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
23035106 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
23035106 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Tnik Protein Structure

STKc_TNIK

STKc_TNIK: cd06637 (17 - 312)

CNH

CNH: smart00036 (1041 - 1339)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1360 a.a.
Protein Preferred Names Protein Names

traf2 and NCK-interacting protein kinase

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-160623 Rentosertib 99.96% Phase 2

Pre-clinical Phase

Bioactive Molecules (30)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-100830 NCB-0846 Inhibitor 99.61% Unkown
HY-10371 Pim1/AAK1-IN-1 Inhibitor 98.40% Unkown
HY-111754 DMX-5804 Inhibitor 99.64% Unkown
HY-124745 KY-05009 99.88% Unkown
HY-N3127 Orobol Inhibitor 99.74% Unkown
HY-145293 TNIK-IN-3 Inhibitor 99.79% Unkown
HY-156816 ON 108600 Inhibitor 98.65% Unkown
HY-149591 M4K-2009 Inhibitor 99.35% Unkown
HY-124762 TNIK-IN-1 Inhibitor 99.25% Unkown
HY-156502 TINK-IN-1 Inhibitor 98.02% Unkown
HY-162314 TNIK-IN-8 Inhibitor 99.58% Unkown
HY-122805 PF-794 Inhibitor 99.19% Unkown
HY-156818 TNIK-IN-7 Inhibitor 99.65% Unkown
HY-100830A NCB-0970 Control 98.81% Unkown
HY-156817 TNIK-IN-6 Inhibitor 98.28% Unkown
HY-143437 TNIK-IN-5 Inhibitor 99.75% Unkown
HY-156523 TNIK&MAP4K4-IN-1 99.73% Unkown
HY-RS14832 Tnik Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14831 TNIK Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-143436 TNIK-IN-4 Inhibitor / Unkown
HY-145292 TNIK-IN-2 Inhibitor 99.68% Unkown
HY-163478 TNIK-IN-9 Inhibitor / Unkown
HY-179111 HPK1-IN-64 Inhibitor / Unkown
HY-181930 TNIK-IN-10 / Unkown
HY-183059 TNIK-IN-11 Inhibitor / Unkown
HY-183950 ALK5-IN-87 Inhibitor / Unkown
HY-RS14833 Tnik Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W402208 MAP4K4-IN-7 Inhibitor / Unkown
HY-149591A M4K2009 hydrochloride Inhibitor / Unkown
HY-180857 TNIK modulator-1 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tnik NCBI NCBI:23043