TRIM21 - tripartite motif containing 21 Gene

Also Known as SSA; RO52; SSA1; RNF81; Ro/SSA

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6737

About TRIM21

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:4,384,897-4,393,702 (from NCBI)

This gene has 2 transcripts (splice variants), 96 orthologues and 80 paralogues. Ubiquitous expression in spleen (RPKM 15.5), appendix (RPKM 13.2) and 24 other tissues.

Summary

This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]

TRIM21 Products (1)

mRNA	Protein	Name
NM_003141.4	NP_003132.2	E3 ubiquitin-protein ligase TRIM21

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	17156811	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8666824	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	23077300	GOA
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	26342464	GOA
enables ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	16297862	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in innate immune response	IDA IDA: Inferred from direct assay	18248090	GOA
involved in negative regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	19675099	GOA
involved in negative regulation of innate immune response	IDA IDA: Inferred from direct assay	26342464	GOA
involved in negative regulation of protein deubiquitination	IMP IMP: Inferred from mutant phenotype	16472766	GOA
involved in negative regulation of viral transcription	IDA IDA: Inferred from direct assay	18248090	GOA
involved in positive regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	23077300	GOA
involved in positive regulation of autophagy	IMP IMP: Inferred from mutant phenotype	26347139	GOA
involved in positive regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	16880511	GOA
involved in positive regulation of protein binding	IMP IMP: Inferred from mutant phenotype	26342464	GOA
involved in proteasomal protein catabolic process	IDA IDA: Inferred from direct assay	36359729	GOA
involved in protein K27-linked ubiquitination	IDA IDA: Inferred from direct assay	26342464	GOA
involved in protein K48-linked ubiquitination	IDA IDA: Inferred from direct assay	36359729	GOA
involved in protein K6-linked ubiquitination	IDA IDA: Inferred from direct assay	36426955	GOA
involved in protein K63-linked ubiquitination	IDA IDA: Inferred from direct assay	36692217	GOA
involved in protein K63-linked ubiquitination	IMP IMP: Inferred from mutant phenotype	26342464	GOA
involved in protein autoubiquitination	IDA IDA: Inferred from direct assay	16880511	GOA
involved in protein destabilization	IMP IMP: Inferred from mutant phenotype	16880511	GOA
involved in protein monoubiquitination	IDA IDA: Inferred from direct assay	16297862	GOA
involved in protein polyubiquitination	IDA IDA: Inferred from direct assay	16297862	GOA
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	16472766	GOA
involved in pyroptotic inflammatory response	IDA IDA: Inferred from direct assay	36426955	GOA
involved in response to type II interferon	IDA IDA: Inferred from direct assay	26347139	GOA
involved in stress granule disassembly	IDA IDA: Inferred from direct assay	36692217	GOA
involved in suppression of viral release by host	IDA IDA: Inferred from direct assay	18248090	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of SCF ubiquitin ligase complex	IDA IDA: Inferred from direct assay	16880511	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	16316627	GOA
is active in cytoplasmic stress granule	IDA IDA: Inferred from direct assay	36692217	GOA
located in nucleus	IDA IDA: Inferred from direct assay	18845142	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRIM21 Protein Structure

zf-C3HC4_4

zf-B_box

PRY

SPRY

0
100
200
300
400
475 a.a.

Protein Preferred Names	Protein Names
E3 ubiquitin-protein ligase TRIM21	52 kDa Ro protein

TRIM21 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TRIM21	P19474	UBE2I	Homo sapiens	Q7KZS0	Y2H Prey Pooling	25416956
Intra	TRIM21	P19474	UBE2I	Homo sapiens	Q7KZS0	Y2H Prey Pooling	32296183
Intra	TRIM21	P19474	UBE2I	Homo sapiens	Q7KZS0	Validated Y2H	32296183
Intra	TRIM21	P19474	UBE2I	Homo sapiens	Q7KZS0	Y2H Array	25416956
Intra	TRIM21	P19474	UBE2I	Homo sapiens	Q7KZS0	Y2H Array	32296183
Intra	TRIM21	P19474	YJU2	Homo sapiens	Q9BW85	Validated Y2H	32296183
Intra	TRIM21	P19474	USP15	Homo sapiens	Q9Y4E8	Y2H Prey Pooling	25416956
Intra	TRIM21	P19474	TRIM39	Homo sapiens	Q9HCM9-2	Validated Y2H	32296183
Intra	TRIM21	P19474	IGFN1	Homo sapiens	Q86VF2-5	Validated Y2H	32296183
Intra	TRIM21	P19474	PRKN	Homo sapiens	O60260-5	Y2H Array	32814053
Intra	TRIM21	P19474	PRKN	Homo sapiens	O60260-5	Y2H Pooling	32814053
Intra	TRIM21	P19474	PRKN	Homo sapiens	O60260-5	Validated Y2H	32814053
Intra	TRIM21	P19474	EHHADH	Homo sapiens	Q08426	Validated Y2H	32296183
Intra	TRIM21	P19474	GMCL1	Homo sapiens	Q96IK5	Validated Y2H	32296183
Intra	TRIM21	P19474	GMCL1	Homo sapiens	Q96IK5	Y2H Prey Pooling	32296183
Intra	TRIM21	P19474	GMCL1	Homo sapiens	Q96IK5	Y2H Array	32296183
Intra	TRIM21	P19474	TCP11L1	Homo sapiens	Q9NUJ3	Validated Y2H	32296183
Intra	TRIM21	P19474	DCTN1	Homo sapiens	Q14203-5	Validated Y2H	32814053
Intra	TRIM21	P19474	DCTN1	Homo sapiens	Q14203-5	Y2H Pooling	32814053
Intra	TRIM21	P19474	DCTN1	Homo sapiens	Q14203-5	Y2H Array	32814053
Intra	TRIM21	P19474	XAF1	Homo sapiens	Q6GPH4	Y2H Prey Pooling	32296183
Intra	TRIM21	P19474	XAF1	Homo sapiens	Q6GPH4	Validated Y2H	32296183
Intra	TRIM21	P19474	XAF1	Homo sapiens	Q6GPH4	Y2H Array	32296183
Intra	TRIM21	P19474	GRAP	Homo sapiens	Q13588	Validated Y2H	25416956
Intra	TRIM21	P19474	GRAP	Homo sapiens	Q13588	Validated Y2H	32296183
Intra	TRIM21	P19474	TXN2	Homo sapiens	Q99757	Validated Y2H	32296183
Intra	TRIM21	P19474	TXN2	Homo sapiens	Q99757	Y2H Array	25416956
Intra	TRIM21	P19474	FHOD1	Homo sapiens	Q9Y613	Validated Y2H	32296183
Intra	TRIM21	P19474	CFTR	Homo sapiens	P13569	Anti Bait CoIP	26618866
Intra	TRIM21	P19474	RNF11	Homo sapiens	Q9Y3C5	Y2H Pooling	32814053
Intra	TRIM21	P19474	RNF11	Homo sapiens	Q9Y3C5	Validated Y2H	32814053
Intra	TRIM21	P19474	RNF11	Homo sapiens	Q9Y3C5	Y2H Array	32814053
Intra	TRIM21	P19474	DMAP1	Homo sapiens	Q9NPF5	Validated Y2H	32296183
Intra	TRIM21	P19474	DMAP1	Homo sapiens	Q9NPF5	Y2H Prey Pooling	32296183
Intra	TRIM21	P19474	DMAP1	Homo sapiens	Q9NPF5	Y2H Array	32296183
Intra	TRIM21	P19474	CBX4	Homo sapiens	O00257-3	Y2H Prey Pooling	32296183
Intra	TRIM21	P19474	CBX4	Homo sapiens	O00257-3	Y2H Array	32296183
Intra	TRIM21	P19474	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	TRIM21	P19474	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	TRIM21	P19474	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	TRIM21	P19474	ZBTB16	Homo sapiens	Q05516	Validated Y2H	32296183
Intra	TRIM21	P19474	UCHL1	Homo sapiens	P09936	Validated Y2H	32814053
Intra	TRIM21	P19474	UCHL1	Homo sapiens	P09936	Y2H Pooling	32814053
Intra	TRIM21	P19474	UCHL1	Homo sapiens	P09936	Y2H Array	32814053
Intra	TRIM21	P19474	USP4	Homo sapiens	Q13107-1	Y2H	11461834
Intra	TRIM21	P19474	TRIM39	Homo sapiens	Q9HCM9	Y2H Array	25416956
Intra	TRIM21	P19474	TRIM39	Homo sapiens	Q9HCM9	Y2H Prey Pooling	25416956
Intra	TRIM21	P19474	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	32296183
Intra	TRIM21	P19474	EXOC8	Homo sapiens	Q8IYI6	Validated Y2H	32296183
Intra	TRIM21	P19474	CWC25	Homo sapiens	Q9NXE8	Validated Y2H	32296183
Intra	TRIM21	P19474	TNS4	Homo sapiens	Q8IZW8	Validated Y2H	32296183
Intra	TRIM21	P19474	TRIM21	Homo sapiens	P19474	Anti Tag CoIP	22493164
Intra	TRIM21	P19474	TRIM21	Homo sapiens	P19474	Y2H	22829933
Intra	TRIM21	P19474	TRIM21	Homo sapiens	P19474	Y2H Prey Pooling	32296183
Intra	TRIM21	P19474	TRIM21	Homo sapiens	P19474	Validated Y2H	32296183
Intra	TRIM21	P19474	TRIM21	Homo sapiens	P19474	Y2H Array	25416956
Intra	TRIM21	P19474	TRIM21	Homo sapiens	P19474	Y2H Array	32296183
Intra	TRIM21	P19474	VPS9D1	Homo sapiens	Q9Y2B5	Validated Y2H	32296183
Intra	TRIM21	P19474	SNCA	Homo sapiens	P37840	Validated Y2H	32814053
Intra	TRIM21	P19474	SNCA	Homo sapiens	P37840	Y2H Pooling	32814053
Intra	TRIM21	P19474	SNCA	Homo sapiens	P37840	Y2H Array	32814053
Cross	TRIM21	P19474	L	Lymphocytic choriomeningitis virus	P14240	Anti Tag CoIP	29261807

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TRIM21 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71791	TRIM21 Protein, Human (P.pastoris, His)	P19474 (M1-Y475)	≥ 90%, as determined by reducing SDS-PAGE.

TRIM21 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80921	TRIM21 Antibody (YA658)	WB	Human
HY-P80921A	TRIM21 Antibody (YA658)(PBS only)	WB	Human

Related Diseases

Diseases	Alias
Lupus Erythematosus	Lupus Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus, Systemic Subacute Cutaneous Lupus Le - [Lupus Erythematosus]
Sjogren Syndrome	Sicca Syndrome Sjogren'S Syndrome Sjögren Syndrome Sjogren-Gougerot Syndrome Keratoconjunctivitis Sicca Sjögren'S Syndrome Xerodermosteosis Dacryosialoadenopathia Atrophicans Gougerot-Houwer-Sjogren Syndrome Gougerot-Sjogren Syndrome Keratoconjunctivitis Sicca-Xerostomia Secreto-Inhibitor-Xerodermostenosis Primary Sjogren Syndrome Primary Sjogren-Gougerot Syndrome Sjogrens Syndrome Primary Sjogrens Syndrome Dry Eye Syndromes
Heart Block, Congenital	Congenital Heart Block Heart Block Congenital Congenital Atrioventricular Block
Subacute Cutaneous Lupus Erythematosus	Lupus Erythematosus Cutaneous Subacute Lupus Erythematosus, Subacute Cutaneous Sacle - [Subacute Cutaneous Lupus Erythematosus] Scle - [Subacute Cutaneous Lupus Erythematosus]
Third-Degree Atrioventricular Block	Third Degree Atrioventricular Block Complete Atrioventricular Block Complete Av Block Third-Degree Block Complete Atrioventricular Heart Block Complete Heart Block Third Degree Atrioventricular Heart Block Third Degree Heart Block Complete Heart Block Nos Chb - [Complete Heart Block] Idioventricular Rhythm Av - [Atrioventricular] Block, Complete
Myositis	Idiopathic Inflammatory Myopathy Idiopathic Inflammatory Myositis Iim Imm Idiopathic Inflammatory Myopathies Myopathy, Familial Idiopathic Inflammatory Inflammatory Disorder Of Muscle Idiopathic Inflammatory Myopathy, Familial Inflammatory Myopathy, Idiopathic Myopathies Idiopathic Inflammatory Familial Idiopathic Inflammatory Myopathy
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Second-Degree Atrioventricular Block	Second-Degree Heart Block Second Degree Atrioventricular Block Second Degree Atrioventricular Heart Block Second Degree Heart Block Incomplete Atrioventricular Block, Second Degree Nos Second-Degree Block, Type 1 And 2 Atrioventricular Block, Type 1 And 2 Second Degree Incomplete Atrioventricular Block Av - [Atrioventricular] Block 2nd
Lymphoid Interstitial Pneumonia	Lymphocytic Interstitial Pneumonia Lip Disease Lip Diseases LIP Disease Of Lips
Xerophthalmia	Conjunctival Xerosis
Autoimmune Disease Of Exocrine System
Systemic Scleroderma	Scleroderma Progressive Systemic Sclerosis Systemic Sclerosis Scleroderma, Systemic Scleroderma Syndrome Dermatosclerosis Familial Progressive Scleroderma Progressive Scleroderma Scleroderma Disease Scleroderma, Localized Diffuse Scleroderma Scleroderma, Familial Progressive
Drug-Induced Lupus Erythematosus	Dile Dil Drug-Induced Systemic Lupus Erythematosus
Cutaneous Lupus Erythematosus	Lupus Erythematosus, Cutaneous Lupus Erythematosus Cutaneous
Lacrimal Apparatus Disease	Lacrimal Apparatus Diseases
Antisynthetase Syndrome	As Syndrome Anti-Jo1 Syndrome
Keratoconjunctivitis
Phototoxic Dermatitis	Dermatitis, Phototoxic Photosensitisation Reaction Photosensitive Dermatitis Photosensitiveness
Potocki-Shaffer Syndrome	Proximal 11p Deletion Syndrome Chromosome 11p11.2 Deletion Syndrome Pss 11p11.2 Deletion P11pds Defect11 Syndrome Deletion Of Chromosome 11p11.2 POSHS
Conjunctival Vascular Disease	Vascular Abnormalities Of Conjunctiva Conjunctival Vascular Abnormality Vascular Abnormality Of Conjunctiva
Lymphocytic Choriomeningitis	Lcm Lymphocytic Meningitis Lymphocytic Choriomeningitis Virus Encephalomyelitis Lymphocytic Meningoencephalitis Non-Arthropod Borne Lymphocytic Choriomeningitis Lcm - [Lymphocytic Choriomeningitis] Benign Lymphocytic Meningitis Meningitis Due To Lymphocytic Choriomeningitis Virus
Parotid Disease	Parotid Diseases
Nonspecific Interstitial Pneumonia	Nsip Non-Specific Interstitial Pneumonia Non-Specific Idiopathic Interstitial Pneumonia Non-Specific Interstitial Pneumonia Nos
Mononeuritis Multiplex
Diffuse Infiltrative Lymphocytosis Syndrome
Sialadenitis	Sialoadenitis Adenitis, Salivary Gland Salivary Gland Inflammation Salivary Gland Adenitis Sialitis Inflammation Of Salivary Gland Inflammation Of Salivary Duct Or Gland Salivary Glandular Adenitis Sialoangiitis Sialoangitis Sialodochitis
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Dry Eye Syndrome	Dry Eye Syndromes Dry Eye Disease Tear Film Insufficiency Xerophthalmia
Transient Neonatal Thrombocytopenia
Transient Neonatal Neutropenia
Endocardial Fibroelastosis	Endomyocardial Fibroelastosis Elastomyofibrosis EFE Efe - [Endocardial Fibroelastosis] Primary Endocardial Fibroelastosis Fibroelastosis Cordis Fetal Endocarditis Fibroelastosis Congenital Endocardial Fibroelastosis Congenital Valvular Endocarditis
Mononeuritis Of Upper Limb And Mononeuritis Multiplex
Adult Dermatomyositis	Adult Onset Dermatomyositis Adult Type Dermatomyositis
Keratoconjunctivitis Sicca	Kcs Dry Eye Syndromes Keratitis Sicca Xerophthalmia
Childhood Type Dermatomyositis	Juvenile Dermatomyositis Juvenile Dm Childhood Dermatomyositis Amyopathic Dermatomyositis Adm Dermatomyositis Sine Myositis Dermatomyositis, Childhood Type
Malignant Secondary Hypertension
Atrioventricular Block	Av Block
Libman-Sacks Endocarditis	Libmann-Sachs, Endocarditis In Systemic Lupus Erythematosus
Idiopathic Interstitial Pneumonia	Hamman-Rich Syndrome Diffuse Idiopathic Pulmonary Fibrosis Idiopathic Fibrosing Alveolitis Ipf Idiopathic Interstitial Pneumonias Idiopathic Interstitial Pneumonia, Not Otherwise Specified Pulmonary Fibrosis
Aphthous Stomatitis	Oral Ulcer Canker Sore Aphtha Aphthous Ulceration Oral Aphthae Oral Aphthous Ulcer Canker Sores Stomatitis, Aphthous Minor Oral Aphthous Ulceration
Chromosomal Deletion Syndrome
Mononeuropathy	Mononeuropathies
Dacryoadenitis	Dacryocystitis
Mikulicz Disease	Igg4-Related Dacryoadenitis And Sialadenitis Mikulicz'S Disease Chronic Dacryoadenitis And Sialadenitis Mikulicz Syndrome Mikulicz' Disease
Axonal Neuropathy
Salivary Gland Disease	Salivary Gland Disorders Salivary Gland Diseases Non-Neoplastic Salivary Gland Disease Non-Neoplastic Salivary Gland Disorder Disorder Of Salivary Gland Lesion Of Salivary Gland Nos
Exanthem	Exanthema Rash Rashes
Parotitis
Autoimmune Disease	Autoimmune Diseases Autoimmune Hypersensitivity Disease Hypersensitivity Reaction Type Ii Disease Type Ii Hypersensitivity Reaction Disease
First-Degree Atrioventricular Block	First Degree Atrioventricular Block First Degree Heart Block Incomplete Atrioventricular Block, First Degree First Degree Atrioventricular Heart Block
Polyclonal Hypergammaglobulinemia	Polyclonal Gammopathy
Diffuse Scleroderma	Diffuse Systemic Sclerosis Systemic Sclerosis, Diffuse Scleroderma, Diffuse Systemic Scleroderma Progressive System Sclerosis
Dyskinesia Of Esophagus	Esophageal Motility Disorders Dyskinesia Of Oesophagus Esophageal Dysmotility Esophageal Motility Disorder Oesophageal Dysmotility Oesophageal Motor Disorder Esophageal Spasm
Limited Scleroderma	Limited Cutaneous Systemic Sclerosis Limited Systemic Sclerosis Systemic Sclerosis Sine Scleroderma Crest Syndrome Limited Cutaneous Systemic Scleroderma Scleroderma, Limited Systemic Sclerosis, Limited Progressive Systemic Sclerosis Sine Scleroderma Scleroderma, Sine Crest - [Calcinosis, Raynaud Phenomenon, Oesophageal Dysmotility, Sclerodactyly, And Telangiectasia] Syndrome Crst - [Calcinosis, Raynaud Phenomenon, Sclerodactyly And Telangiectasia] Syndrome
Raynaud Disease	Raynaud'S Disease Raynaud Phenomenon Raynaud'S Syndrome Raynaud'S Cold Fingers, Hereditary Raynaud'S Phenomenon Raynaud'S Disease/Phenomenon Raynauds Syndrome Raynauds Phenomenon Secondary Raynaud'S Phenomenon Raynaud Syndrome
Transverse Myelitis	Myelitis Transverse Myelitis, Transverse
Collagen Disease	Collagen Diseases Collagen Disorder
Temporal Arteritis	Polymyalgia Rheumatica Giant Cell Arteritis Cranial Arteritis Horton Disease Gca Horton'S Disease Rhizomelic Pseudopolyarthritis Arteritis Cranialis Arteritis Temporalis Horton'S Arteritis Horton'S Giant Cell Arteritis Horton'S Temporal Arteritis Horton'S Syndrome Gca - [Giant Cell Arteritis] Senile Arthritis Polymyalgia Arteritica Pmr - [Polymyalgia Rheumatica] Forestier-Certonciny Syndrome Rheumatic Polymyalgia Polymyalgia
Telangiectasis	Telangiectasia
Autoimmune Disease Of Musculoskeletal System
Punctate Epithelial Keratoconjunctivitis	Punctate Keratitis Thygeson Superficial Punctate Keratitis Thygeson'S Superficial Punctate Keratitis Thygeson Superficial Punctate Keratopathy Punctate Epithelial Keratitis
Pericardium Disease
Hypersensitivity Reaction Type Iv Disease	Immunoproliferative Disorders Immunoproliferative Disease
Autoimmune Disease Of Cardiovascular System
Chromosomal Disease	Chromosomal Disorders Congenital Chromosomal Disease
Heart Conduction Disease	Conduction Disorder Of The Heart Heart Rhythm Disease
Muscle Tissue Disease
Hyperlipoproteinemia, Type V	Hyperlipoproteinemia Type V Hyperchylomicronemia, Late-Onset Familial Type 5 Hyperlipoproteinemia Hyperchylomicronemia With Hyperprebetalipoproteinemia, Familial Hyperlipidemia, Type V Hyperlipemia, Mixed Hyperlipemia, Combined Fat And Carbohydrate-Induced Familial Hyperlipoproteinemia Type V Fredrickson Type V Lipaemia Hyperlipoproteinemia Type 5 Hyperchylomicronemia Late Onset Hyperlipemia Combined Fat And Carbohydrate-Induced Hyperlipemia Mixed Hyperlipidemia Type V Mixed Hyperlipemia Type V Hyperlipoproteinemia Hyperlipoproteinemia 5 HLPP5 Hyperlipidemia, Familial Combined Mixed Hyperlipidemia
Primary Biliary Cholangitis	Primary Biliary Cirrhosis Biliary Liver Cirrhosis Chronic Nonsuppurative Destructive Cholangitis Familial Primary Biliary Cirrhosis Pbc Hanot Syndrome Cholestatic Cirrhosis Biliary Cirrhosis Primary Liver Cirrhosis, Biliary Hanot'S Cirrhosis Biliary Cirrhosis Pericholangiolic Biliary Cirrhosis Tannhauser-Magendantz Syndrome Hanot-Rossle Syndrome Hypertrophic Cirrhosis Todd Cirrhosis Hanot Cirrhosis Charcot Cirrhosis Mahon-Tannhauser Syndrome Toxic Cirrhosis Hypertrophic Biliary Cirrhosis Monolobular Cirrhosis Unilobar Cirrhosis Xanthomatous Biliary Cirrhosis
Skin Disease	Skin Diseases Genodermatosis Abnormality Of The Skin Skin Diseases, Genetic Skin And Subcutaneous Tissue Disease Dermatologic Disorders
Myopathy	Muscular Diseases Myopathies
Connective Tissue Disease	Connective Tissue Diseases Connective Tissue Disorder Abnormality Of Connective Tissue Disorder Of Connective Tissue Connective Tissue Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-169356	Acepromazine-OTs		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TRIM21	RGD	RGD:1305795
Bos taurus	TRIM21	VGNC	VGNC:36319
Felis catus	TRIM21	VGNC	VGNC:66530
Mus musculus	TRIM21	MGD	MGI:106657
Macaca mulatta	TRIM21	VGNC	VGNC:78556
Canis familiaris	TRIM21	VGNC	VGNC:47808
Others	TRIM21	NCBI