STK4 - serine/threonine kinase 4 Gene

Also Known as KRS2; MST1; YSK3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6789

About STK4

Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:44,966,512-45,080,021 (from NCBI)

This gene has 17 transcripts (splice variants), 130 orthologues, 35 paralogues and is associated with 2 phenotypes. Broad expression in lymph node (RPKM 17.1), appendix (RPKM 14.6) and 24 other tissues.

Summary

The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with Apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process. [provided by RefSeq, Jul 2008]

STK4 Products (2)

mRNA	Protein	Name
NM_001352385.2	NP_001339314.1	serine/threonine-protein kinase 4 isoform 2
NM_006282.5	NP_006273.1	serine/threonine-protein kinase 4 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATP binding	IDA IDA: Inferred from direct assay	8566796	GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	16751106	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	8702870	GOA
enables magnesium ion binding	IDA IDA: Inferred from direct assay	8566796	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	14729613	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	11805089	GOA
enables protein kinase activity	IGI IGI: Inferred from genetic interaction	19962960	GOA
enables protein serine/threonine kinase activity	EXP EXP: Inferred from Experiment	9545236	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	8566796	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in apoptotic process	IDA IDA: Inferred from direct assay	21212262	GOA
acts upstream of or within cell morphogenesis	IDA IDA: Inferred from direct assay	11805089	GOA
involved in hippo signaling	IDA IDA: Inferred from direct assay	20412773	GOA
involved in intracellular signal transduction	IDA IDA: Inferred from direct assay	8566796	GOA
involved in negative regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	20412773	GOA
involved in peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	16751106	GOA
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	15109305	GOA
acts upstream of or within positive regulation of hippo signaling	IDA IDA: Inferred from direct assay	22292086	GOA
acts upstream of or within positive regulation of peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	19962960	GOA
acts upstream of or within positive regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	19962960	GOA
acts upstream of or within protein autophosphorylation	IDA IDA: Inferred from direct assay	11805089	GOA
involved in protein import into nucleus	IDA IDA: Inferred from direct assay	16751106	GOA
involved in protein import into nucleus	IGI IGI: Inferred from genetic interaction	16751106	GOA
acts upstream of or within protein phosphorylation	IDA IDA: Inferred from direct assay	11805089	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	8566796	GOA
acts upstream of or within protein stabilization	IDA IDA: Inferred from direct assay	19962960	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in cytoplasm	IDA IDA: Inferred from direct assay	35429439	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	17932490	GOA
located in nucleus	IDA IDA: Inferred from direct assay	17932490	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	19962960	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STK4 Protein Structure

Pkinase

Mst1_SARAH

0
100
200
300
400
487 a.a.

Protein Preferred Names	Protein Names
serine/threonine-protein kinase 4	STE20-like kinase MST1

STK4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	STK4	Q13043	SAV1	Homo sapiens	Q9H4B6	BioID	24255178
Intra	STK4	Q13043	SAV1	Homo sapiens	Q9H4B6	Anti Tag CoIP	24366813
Intra	STK4	Q13043	SAV1	Homo sapiens	Q9H4B6	Anti Tag CoIP	20920251
Intra	STK4	Q13043	SAV1	Homo sapiens	Q9H4B6	Anti Tag CoIP	16930133
Intra	STK4	Q13043	SAV1	Homo sapiens	Q9H4B6	Anti Tag CoIP	20562859
Intra	STK4	Q13043	SAV1	Homo sapiens	Q9H4B6	TAP	24981860
Intra	STK4	Q13043	SAV1	Homo sapiens	Q9H4B6	Anti Tag CoIP	24255178
Intra	STK4	Q13043	SAV1	Homo sapiens	Q9H4B6	TAP	23455922
Intra	STK4	Q13043	SAV1	Homo sapiens	Q9H4B6	TAP	23386615
Intra	STK4	Q13043	SLMAP	Homo sapiens	Q14BN4	BioID	24255178
Intra	STK4	Q13043	SLMAP	Homo sapiens	Q14BN4	Anti Tag CoIP	35271311
Intra	STK4	Q13043	SLMAP	Homo sapiens	Q14BN4	Anti Tag CoIP	24366813
Cross	STK4	Q13043	Stk38	Mus musculus	Q91VJ4	Protein Kinase Assay	21730291
Intra	STK4	Q13043	RASSF3	Homo sapiens	Q86WH2	Anti Tag CoIP	35271311
Intra	STK4	Q13043	RASSF3	Homo sapiens	Q86WH2	Anti Tag CoIP	20920251
Intra	STK4	Q13043	RASSF3	Homo sapiens	Q86WH2	TAP	23455922
Intra	STK4	Q13043	RASSF3	Homo sapiens	Q86WH2	BioID	24255178
Intra	STK4	Q13043	RASSF3	Homo sapiens	Q86WH2	Anti Tag CoIP	24366813
Intra	STK4	Q13043	RASSF4	Homo sapiens	Q9H2L5	Anti Tag CoIP	20562859
Intra	STK4	Q13043	RASSF4	Homo sapiens	Q9H2L5	TAP	23455922
Intra	STK4	Q13043	RASSF4	Homo sapiens	Q9H2L5	Y2H	20920251
Intra	STK4	Q13043	RASSF4	Homo sapiens	Q9H2L5	Anti Tag CoIP	35271311
Intra	STK4	Q13043	RASSF4	Homo sapiens	Q9H2L5	Anti Tag CoIP	24366813
Intra	STK4	Q13043	RASSF6	Homo sapiens	Q6ZTQ3	Anti Tag CoIP	24366813
Intra	STK4	Q13043	RASSF6	Homo sapiens	Q6ZTQ3	Anti Tag CoIP	35271311
Intra	STK4	Q13043	RASSF6	Homo sapiens	Q6ZTQ3	Anti Tag CoIP	20920251
Intra	STK4	Q13043	AKT1	Homo sapiens	P31749	Anti Bait CoIP	17932490
Intra	STK4	Q13043	AKT1	Homo sapiens	P31749	Anti Tag CoIP	17932490
Intra	STK4	Q13043	AKT1	Homo sapiens	P31749	IF	17932490
Intra	STK4	Q13043	PRDX1	Homo sapiens	Q06830	TAP	23386615
Intra	STK4	Q13043	PRDX1	Homo sapiens	Q06830	Anti Tag CoIP	23386615
Intra	STK4	Q13043	PRDX1	Homo sapiens	Q06830	Protein Kinase Assay	23386615
Intra	STK4	Q13043	RASSF5	Homo sapiens	Q8WWW0	TAP	24981860
Intra	STK4	Q13043	RASSF5	Homo sapiens	Q8WWW0	Anti Tag CoIP	20562859
Intra	STK4	Q13043	RASSF5	Homo sapiens	Q8WWW0	TAP	23455922
Intra	STK4	Q13043	RASSF5	Homo sapiens	Q8WWW0	BioID	24255178
Intra	STK4	Q13043	RASSF5	Homo sapiens	Q8WWW0	Anti Tag CoIP	24366813
Intra	STK4	Q13043	RASSF5	Homo sapiens	Q8WWW0	Anti Tag CoIP	35271311
Intra	STK4	Q13043	MAP1LC3B	Homo sapiens	Q9GZQ8	Pull Down	20562859
Intra	STK4	Q13043	RASSF1	Homo sapiens	Q9NS23-2	CoIP	15109305
Intra	STK4	Q13043	RASSF1	Homo sapiens	Q9NS23-2	Y2H	14729613
Intra	STK4	Q13043	RASSF1	Homo sapiens	Q9NS23-2	Anti Tag CoIP	20920251
Intra	STK4	Q13043	RASSF1	Homo sapiens	Q9NS23-2	Y2H	20920251
Cross	STK4	Q13043	Prdx1	Mus musculus	P35700	Anti Tag CoIP	21516123
Cross	STK4	Q13043	Prdx1	Mus musculus	P35700	Protein Kinase Assay	21516123
Intra	STK4	Q13043	GABARAP	Homo sapiens	O95166	Pull Down	20562859
Intra	STK4	Q13043	GABARAPL2	Homo sapiens	P60520	Pull Down	20562859
Intra	STK4	Q13043	GABARAPL1	Homo sapiens	Q9H0R8	Pull Down	20562859
Intra	STK4	Q13043	MOB1A	Homo sapiens	Q9H8S9	Anti Tag CoIP	24255178
Intra	STK4	Q13043	MOB1A	Homo sapiens	Q9H8S9	Protein Kinase Assay	21516123
Intra	STK4	Q13043	MOB1A	Homo sapiens	Q9H8S9	TAP	23386615
Intra	STK4	Q13043	RASSF2	Homo sapiens	P50749	Anti Tag CoIP	35271311
Intra	STK4	Q13043	RASSF2	Homo sapiens	P50749	Anti Tag CoIP	20920251
Intra	STK4	Q13043	RASSF2	Homo sapiens	P50749	TAP	23386615
Intra	STK4	Q13043	RASSF2	Homo sapiens	P50749	TAP	24981860
Intra	STK4	Q13043	RASSF2	Homo sapiens	P50749	Y2H	20920251
Intra	STK4	Q13043	RASSF2	Homo sapiens	P50749	Anti Tag CoIP	20562859
Intra	STK4	Q13043	RASSF2	Homo sapiens	P50749	Anti Tag CoIP	24255178
Intra	STK4	Q13043	RASSF2	Homo sapiens	P50749	TAP	23455922
Intra	STK4	Q13043	RASSF2	Homo sapiens	P50749	BioID	24255178
Intra	STK4	Q13043	RASSF2	Homo sapiens	P50749	Anti Tag CoIP	24366813
Intra	STK4	Q13043	RASSF5	Homo sapiens	Q8WWW0-3	Y2H	20920251
Intra	STK4	Q13043	STK3	Homo sapiens	Q13188	Anti Tag CoIP	24255178
Intra	STK4	Q13043	STK3	Homo sapiens	Q13188	TAP	23455922
Intra	STK4	Q13043	STK3	Homo sapiens	Q13188	BioID	24255178
Intra	STK4	Q13043	STK3	Homo sapiens	Q13188	TAP	23386615
Intra	STK4	Q13043	STK3	Homo sapiens	Q13188	Anti Tag CoIP	35271311
Intra	STK4	Q13043	STK3	Homo sapiens	Q13188	Anti Tag CoIP	24366813
Intra	STK4	Q13043	STK3	Homo sapiens	Q13188	TAP	24981860
Intra	STK4	Q13043	STK3	Homo sapiens	Q13188	Anti Tag CoIP	20562859

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant STK4 Proteins

Cat. No.	상품명	Accession	Purity
HY-P74742	MST1/STK4 Protein, Human (Active, sf9, His)	Q13043-1 (E2-F487)	≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
T-Cell Immunodeficiency, Recurrent Infections, And Autoimmunity With Or Without Cardiac Malformations	Combined Immunodeficiency Due To Stk4 Deficiency TIIAC Stk4 Deficiency Mst1 Deficiency T-Cell Immunodeficiency, Recurrent Infections, Autoimmunity, And Cardiac Malformations Cid Due To Stk4 Deficiency
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Immunodeficiency 63 With Lymphoproliferation And Autoimmunity	IMD63 Il2rb Deficiency Cd122 Deficiency Immunodeficiency 63 Interleukin 2 Receptor, Beta, Deficiency Of Deficiency Of Interleukin 2 Receptor Beta
Lymphoproliferative Syndrome 2	Cd27 Deficiency LPFS2 Combined Immunodeficiency Due To Cd27 Deficiency Autosomal Recessive Lymphoproliferative Disease Due To Cd27 Deficiency
Coronin-1a Deficiency
Epidermodysplasia Verruciformis 1	Epidermodysplasia Verruciformis Epidermodysplasia Verruciformis, Susceptibility To, 1 Lutz-Lewandowsky Epidermodysplasia Verruciformis EV1 Lewandowsky-Lutz Syndrome Ev
Endometrial Cancer	Endometrial Carcinoma Endometrial Neoplasm Malignant Neoplasm Of Endometrium Endometrioid Carcinoma Endometrial Neoplasms Carcinoma, Endometrioid Endometrial Cancer, Familial Endometrial Carcinoma, Somatic Endometrial Cancer, Susceptibility To Endometrial Ca Malignant Endometrial Neoplasm Neoplasm Of Endometrium Primary Malignant Neoplasm Of Endometrium Tumor Of Endometrium Carcinoma Of The Endometrium Endometrioid Carcinoma Of Female Reproductive System ENDMC Carcinoma Endometrioid Endometrial Cancers Cancer, Endometrial Uterine Corpus Cancer
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-132969	SBP-3264		98.50%	Unkown
HY-137340	WH-10417-099	Degrader	98.14%	Unkown
HY-RS09991	Pak3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS13941	STK4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18154	Stk4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24628	Stk4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	STK4	VGNC	VGNC:81228
Rattus norvegicus	STK4	RGD	RGD:1312035
Mus musculus	STK4	MGD	MGI:1929004
Canis familiaris	STK4	VGNC	VGNC:46922
Bos taurus	STK4	VGNC	VGNC:35401
Macaca mulatta	STK4	VGNC	VGNC:81588
Others	STK4	NCBI