TFF1 - trefoil factor 1 Gene

Homo sapiens

Also known as pS2; BCEI; HPS2; HP1.A; pNR-2; D21S21

Gene ID: 7031 | Gene type: protein coding

About TFF1

Cytogenetic location: 21q22.3 Genomic coordinates (GRCh38): 21:42,362,282-42,366,535 (from NCBI)

This gene has 1 transcript (splice variant), 84 orthologues and 2 paralogues. Restricted expression toward stomach (RPKM 2677.9).

Summary

Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer, and affect healing of the epithelium. This gene, which is expressed in the gastric mucosa, has also been studied because of its expression in human tumors. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008]

TFF1 Products(1)

mRNA	Protein	Name
NM_003225.3	NP_003216.1	trefoil factor 1 precursor

TFF1 Protein Structure

Trefoil

0
84 a.a.

Protein Preferred Names

Protein Names

trefoil factor 1

breast cancer estrogen-inducible protein

Recombinant TFF1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71072	TFF1 Protein, Human (HEK293, His)	P04155 (E25-F84)	≥95%
HY-P71928	TFF1 Protein, Human	P04155 (E25-F84)	≥95%
HY-P700509	TFF1 Protein, Human (P. pastoris, N-His)	P04155 (E25-F84)	≥95%

Related Diseases

Diseases

Alias

Gastric Ulcer

Stomach Ulcer	Acute Gastric Ulcer With Haemorrhage And Perforation
Acute Gastric Ulcer With Hemorrhage And Obstruction	Acute Gastric Ulcer With Hemorrhage And Perforation
Acute Gastric Ulcer With Hemorrhage And Perforation, With Obstruction	Acute Gastric Ulcer With Hemorrhage And Perforation, Without Mention Of Obstruction
Acute Gastric Ulcer With Hemorrhage And With Perforation But Without Obstruction	Acute Gastric Ulcer With Hemorrhage, With Obstruction
Acute Gastric Ulcer With Hemorrhage, With Perforation And With Obstruction	Acute Gastric Ulcer With Perforation
Acute Gastric Ulcer With Perforation And Obstruction	Acute Gastric Ulcer With Perforation, With Obstruction
Acute Gastric Ulcer Without Hemorrhage And Without Perforation	Acute Gastric Ulcer Without Hemorrhage, Without Perforation And Without Obstruction
Acute Gastric Ulcer Without Mention Of Hemorrhage Or Perforation, Without Mention Of Obstruction	Bleeding Acute Gastric Ulcer
Chronic Gastric Ulcer Without Hemorrhage And Without Perforation	Chronic Gastric Ulcer Without Hemorrhage And Without Perforation But With Obstruction
Chronic Gastric Ulcer Without Mention Of Hemorrhage Or Perforation, With Obstruction	Gastric Ulcers
Cushings Ulcer	Cushing'S Ulcer Of Stomach
Peptic Ulcer Of Stomach	Mucosal Defect Of The Stomach

Bile Reflux

Breast Ductal Carcinoma

Ductal Breast Carcinoma	Duct Carcinoma
Carcinoma, Ductal	Mammary Ductal Carcinoma
Ductal Carcinoma

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Breast Disease

Breast Diseases

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Atrophic Gastritis

Gastritis, Atrophic	Gastric Atrophy
Gastritis Atrophic

Gastric Adenocarcinoma

Adenocarcinoma Of Stomach	Stomach Adenocarcinoma
Adenocarcinoma Gastric	Intestinal Type Adenocarcinoma Of Unspecified Site
Diffuse Type Adenocarcinoma Of Unspecified Site

Cholecystitis

Acute Cholecystitis	Chronic Cholecystitis
Acalculous Cholecystitis	Acute And Chronic Cholecystitis
Acute On Chronic Cholecystitis	Gallstone Cholecystitis
Cholecystitis, Acute	Calculus Of Gallbladder With Cholecystitis
Gallbladder Inflammation	Acute Cholecystitis Infection
Acute Acalculous Cholecystitis	Chronic Acalculous Cholecystitis
Nonfunctioning Gallbladder

Gastrointestinal Carcinoma

Gastrointestinal Neoplasms

Alcoholic Gastritis

Alcoholic Gastritis, With Hemorrhage	Alcoholic Gastritis, Without Mention Of Hemorrhage
Alcohol Gastritis	Etoh Gastritis

Nephrolithiasis

Kidney Stones	Stone - Kidney/Ureter
Kidney Calculi

Mucinous Cystadenocarcinoma

Cystadenocarcinoma, Mucinous	Pseudomucinous Cystadenocarcinoma
Cystadenocarcinoma Mucinous

Breast Fibroadenoma

Fibroadenoma	Fibroadenoma Of Breast
Juvenile Fibroadenoma Of Breast	Cellular Fibroadenoma
Complex Fibroadenoma Of Breast	Juvenile Fibroadenoma
Fibroadenoma Nos	Fibroadenoma Unspecified Site

Barrett Esophagus

Barrett'S Esophagus	Barrett Esophagus/Esophageal Adenocarcinoma
Barrett Metaplasia	Barrett'S Ulcer Of Esophagus
Ulcerative Esophagitis	Barrett'S Esophagus With Esophagitis
Barrett'S Oesophagus	Barretts Syndrome
Barrett Syndrome	BE
Peptic Ulcer Of Esophagus	Adenocarcinoma Of Esophagus

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Cholangiocarcinoma

Cholangiocarcinoma, Susceptibility To	Extrahepatic Cholangiocarcinoma
Intrahepatic Cholangiocarcinoma	Chlc
Chlc, Susceptibility To	Cc
Cholangiocarcinoma Of Biliary Tract	Cholangiocellular Carcinoma
Distal Cholangiocarcinoma	Perihilar Cholangiocarcinoma
Bile Duct Cancer	Cca
Adult Primary Cholangiocellular Carcinoma	Bile Duct Carcinoma

Pancreatic Cancer

Pancreatic Carcinoma	Carcinoma Of Pancreas
Familial Pancreatic Carcinoma	Pancreatic Neoplasm
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Cancer Of The Pancreas	Pancreatic Carcinoma, Somatic
Pancreatic Cancer, Somatic	Ca Body Of Pancreas
Ca Head Of Pancreas	Ca Tail Of Pancreas
Malignant Neoplasm Of Body Of Pancreas	Malignant Neoplasm Of Head Of Pancreas
Malignant Neoplasm Of Tail Of Pancreas	Pancreas Neoplasm
Exocrine Cancer	Exocrine Pancreas Carcinoma
Hereditary Pancreatic Cancer	Hereditary Pancreatic Carcinoma
PNCA	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Endometrial Cancer

Endometrial Carcinoma	Endometrial Neoplasm
Malignant Neoplasm Of Endometrium	Endometrioid Carcinoma
Endometrial Neoplasms	Carcinoma, Endometrioid
Endometrial Cancer, Familial	Endometrial Carcinoma, Somatic
Endometrial Cancer, Susceptibility To	Endometrial Ca
Malignant Endometrial Neoplasm	Neoplasm Of Endometrium
Primary Malignant Neoplasm Of Endometrium	Tumor Of Endometrium
Carcinoma Of The Endometrium	Endometrioid Carcinoma Of Female Reproductive System
ENDMC	Carcinoma Endometrioid
Endometrial Cancers	Cancer, Endometrial
Uterine Corpus Cancer

Amelogenesis Imperfecta, Type Ig

Enamel-Renal Syndrome	Ers
Amelogenesis Imperfecta Type 1g	AI1G
Enamel-Renal-Gingival Syndrome	Amelogenesis Imperfecta And Gingival Fibromatosis Syndrome
Aigfs	Amelogenesis Imperfecta, Hypoplastic, With Nephrocalcinosis
Amelogenesis Imperfecta Hypoplastic With Nephrocalcinosis	Amelogenesis Imperfecta Type Ig
Amelogenesis Imperfecta-Nephrocalcinosis Syndrome	Amelogenesis Imperfecta 1g
Hypoplastic Amelogenesis Imperfecta With Nephrocalcinosis	Amelogenesis Imperfecta Nephrocalcinosis

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Cancer Of The Ovary
Epithelial Ovarian Cancer	Neoplasm Of Ovary
Ovarian Neoplasms	Ovarian Cancers
Malignant Neoplasm Of Ovary	Primary Malignant Neoplasm Of Ovary
Ovarian Cancer, Somatic	Malignant Ovarian Tumor
Ovary Neoplasm	Primary Ovarian Cancer
Tumor Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Amelogenesis Imperfecta

Ai	Congenital Enamel Hypoplasia
Al - [Amelogenesis Imperfecta]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14422	TFF1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TFF1	RGD	RGD:620707
Felis catus	TFF1	VGNC	VGNC:66119
Bos taurus	TFF1	VGNC	VGNC:35790
Macaca mulatta	TFF1	VGNC	VGNC:108446
Mus musculus	TFF1	MGD	MGI:88135
Canis familiaris	TFF1	VGNC	VGNC:47296
Others	TFF1	NCBI