TTK - TTK protein kinase Gene

Homo sapiens

Also known as ESK; PYT; CT96; MPH1; MPS1; MPS1L1

Gene ID: 7272 | Gene type: protein coding

About TTK

Cytogenetic location: 6q14.1 Genomic coordinates (GRCh38): 6:80,004,649-80,042,527 (from NCBI)

This gene has 11 transcripts (splice variants), 205 orthologues and 2 paralogues. Biased expression in testis (RPKM 13.6), bone marrow (RPKM 6.1) and 10 other tissues.

Summary

This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]

TTK Products(2)

mRNA	Protein	Name
NM_001166691.2	NP_001160163.1	dual specificity protein kinase TTK isoform 2
NM_003318.5	NP_003309.2	dual specificity protein kinase TTK isoform 1

TTK Protein Structure

Pkinase

0
200
400
600
800
857 a.a.

Protein Preferred Names

Protein Names

dual specificity protein kinase TTK

cancer/testis antigen 96

Related Diseases

Diseases

Alias

Pancreatic Cancer

Pancreatic Carcinoma	Carcinoma Of Pancreas
Familial Pancreatic Carcinoma	Pancreatic Neoplasm
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Cancer Of The Pancreas	Pancreatic Carcinoma, Somatic
Pancreatic Cancer, Somatic	Ca Body Of Pancreas
Ca Head Of Pancreas	Ca Tail Of Pancreas
Malignant Neoplasm Of Body Of Pancreas	Malignant Neoplasm Of Head Of Pancreas
Malignant Neoplasm Of Tail Of Pancreas	Pancreas Neoplasm
Exocrine Cancer	Exocrine Pancreas Carcinoma
Hereditary Pancreatic Cancer	Hereditary Pancreatic Carcinoma
PNCA	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-143904	PROTAC TTK degrader-1	Antagonist	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (13)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-14710	AZ3146	Inhibitor	99.92%	Unkown
HY-116673	TTK21	Activator	99.43%	Unkown
HY-101340A	Luvixasertib hydrochloride	Inhibitor	99.48%	Unkown
HY-108709	CC-671	Inhibitor	99.06%	Unkown
HY-100024	NTRC 0066-0		99.01%	Unkown
HY-19544	JAK3-IN-1	Inhibitor	99.23%	Unkown
HY-144308	RMS-07	Inhibitor	/	Unkown
HY-132884	TTK inhibitor 3	Inhibitor	/	Unkown
HY-110347	Mps1-IN-1 dihydrochloride	Inhibitor	/	Unkown
HY-143905	PROTAC TTK degrader-2	Antagonist	/	Unkown
HY-160419	Mps1-IN-8	Inhibitor	/	Unkown
HY-162156	TTK inhibitor 4		/	Unkown
HY-RS15226	TTK Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TTK	VGNC	VGNC:47971
Rattus norvegicus	TTK	RGD	RGD:1305558
Bos taurus	TTK	VGNC	VGNC:36487
Macaca mulatta	TTK	VGNC	VGNC:78670
Mus musculus	TTK	MGD	MGI:1194921
Felis catus	TTK	VGNC	VGNC:66683
Others	TTK	NCBI

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