TTK - TTK protein kinase Gene

Also Known as ESK; PYT; CT96; MPH1; MPS1; MPS1L1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7272

About TTK

Cytogenetic location: 6q14.1 Genomic coordinates (GRCh38): 6:80,004,649-80,042,527 (from NCBI)

This gene has 11 transcripts (splice variants), 205 orthologues and 2 paralogues. Biased expression in testis (RPKM 13.6), bone marrow (RPKM 6.1) and 10 other tissues.

Summary

This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during Mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during Mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]

TTK Products (2)

mRNA Protein Name
NM_001166691.2 NP_001160163.1 dual specificity protein kinase TTK isoform 2
NM_003318.5 NP_003309.2 dual specificity protein kinase TTK isoform 1

TTK Protein Structure

Pkinase

Pkinase: Protein kinase domain (525 - 791)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 857 a.a.
Protein Preferred Names Protein Names

dual specificity protein kinase TTK

  • cancer/testis antigen 96

Related Diseases

Diseases Alias
Pancreatic Cancer

  • Pancreatic Carcinoma

  • Carcinoma Of Pancreas

  • Familial Pancreatic Carcinoma

  • Pancreatic Neoplasm

  • Pancreatic Carcinoma, Familial

  • Malignant Neoplasm Of Pancreas

  • Pancreatic Acinar Carcinoma

  • Pancreatic Tumor

  • Familial Pancreatic Cancer

  • Neoplasm Of The Pancreas

  • Cancer Of The Pancreas

  • Pancreatic Carcinoma, Somatic

  • Pancreatic Cancer, Somatic

  • Ca Body Of Pancreas

  • Ca Head Of Pancreas

  • Ca Tail Of Pancreas

  • Malignant Neoplasm Of Body Of Pancreas

  • Malignant Neoplasm Of Head Of Pancreas

  • Malignant Neoplasm Of Tail Of Pancreas

  • Pancreas Neoplasm

  • Exocrine Cancer

  • Exocrine Pancreas Carcinoma

  • Hereditary Pancreatic Cancer

  • Hereditary Pancreatic Carcinoma

  • PNCA

  • Pancreatic Cancer, Susceptibility To

  • Carcinoma Of Head Of Pancreas

  • Pancreatic Neoplasms

  • Pancreatic Tumors

  • Cancer, Pancreatic

  • Cancer Of Pancreas

  • Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-101340 Luvixasertib Inhibitor 99.9600% Phase 2
HY-143904 PROTAC TTK degrader-1 Degrader 98.01% Phase 2

Pre-clinical Phase

Bioactive Molecules (28)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-116673 TTK21 Activator 99.39% Unkown
HY-14710 AZ3146 Inhibitor 99.42% Unkown
HY-101340A Luvixasertib hydrochloride Inhibitor 99.63% Unkown
HY-108709 CC-671 Inhibitor 99.06% Unkown
HY-171770 dAurAB5 99.03% Unkown
HY-168543 PROTAC AURKA degrader 3 Degrader 99.78% Unkown
HY-19544 JAK3-IN-1 Inhibitor 99.31% Unkown
HY-100024 NTRC 0066-0 Inhibitor 99.02% Unkown
HY-149213 LSD1/TLK1-IN-1 99.20% Unkown
HY-168540 PROTAC MPS1 degrader 1 99.90% Unkown
HY-168542 TTK ligand 2 Ligand 99.43% Unkown
HY-168545 SF-1 Ligand 99.50% Unkown
HY-144308 RMS-07 Inhibitor / Unkown
HY-132884 TTK inhibitor 3 Inhibitor / Unkown
HY-110347 Mps1-IN-1 dihydrochloride Inhibitor / Unkown
HY-116190 CFI-401870 Inhibitor / Unkown
HY-123675 CFI-400936 Inhibitor / Unkown
HY-143905 PROTAC TTK degrader-2 Degrader / Unkown
HY-160419 Mps1-IN-8 Inhibitor / Unkown
HY-162156 TTK inhibitor 4 Inhibitor / Unkown
HY-164955 TTK/PLK1-IN-1 Inhibitor / Unkown
HY-179430 TTK-IN-5 Inhibitor / Unkown
HY-182928 LRRK2-IN-21 Inhibitor / Unkown
HY-RS15226 TTK Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-116470 Mps1/TTK-IN-1 Inhibitor / Unkown
HY-RS16792 Ttk Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21071 Ttbk2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23232 Ttk Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris TTK VGNC VGNC:47971
Rattus norvegicus TTK RGD RGD:1305558
Bos taurus TTK VGNC VGNC:36487
Macaca mulatta TTK VGNC VGNC:78670
Mus musculus TTK MGD MGI:1194921
Felis catus TTK VGNC VGNC:66683
Others TTK NCBI