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Il33 - interleukin 33 Gene

Also Known as Il-33; Il1f11; NF-HEV; 9230117N10Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 77125

Summary

Enables cytokine activity and interleukin-33 receptor binding activity. Involved in several processes, including interleukin-33-mediated signaling pathway; microglial cell activation involved in immune response; and regulation of gene expression. Acts upstream of or within several processes, including negative regulation of macrophage proliferation; positive regulation of cellular defense response; and positive regulation of macromolecule metabolic process. Located in nucleus. Is expressed in several structures, including adrenal gland; alimentary system; genitourinary system; nervous system; and sensory organ. Used to study Alzheimer's disease. Human ortholog(s) of this gene implicated in candidiasis; inflammatory bowel disease; and peptic ulcer disease. Orthologous to human IL33 (interleukin 33). [provided by Alliance of Genome Resources, Apr 2022]

Il33 Products (3)

mRNA	Protein	Name
NM_001164724.2	NP_001158196.1	interleukin-33
NM_001360725.1	NP_001347654.1	interleukin-33
NM_133775.3	NP_598536.2	interleukin-33

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cytokine activity	IDA IDA: Inferred from direct assay	19841166	MGI
enables cytokine activity	IPI IPI: Inferred from physical interaction	17623648	MGI
enables interleukin-33 receptor binding	IPI IPI: Inferred from physical interaction	29045903	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	29045903	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in chemokine production	IDA IDA: Inferred from direct assay	32144162	MGI
involved in cytokine production	IDA IDA: Inferred from direct assay	32144162	MGI
acts upstream of or within defense response to virus	IDA IDA: Inferred from direct assay	23630360	MGI
acts upstream of or within extrinsic apoptotic signaling pathway	IGI IGI: Inferred from genetic interaction	22660580	MGI
acts upstream of gene expression	IDA IDA: Inferred from direct assay	19666510	MGI
involved in gene expression	IDA IDA: Inferred from direct assay	32144162	MGI
involved in interleukin-33-mediated signaling pathway	IDA IDA: Inferred from direct assay	26936882	MGI
involved in macrophage activation involved in immune response	IDA IDA: Inferred from direct assay	21494550	MGI
involved in macrophage differentiation	IDA IDA: Inferred from direct assay	34644537	MGI
involved in microglial cell activation involved in immune response	IDA IDA: Inferred from direct assay	21349253	MGI
involved in microglial cell proliferation	IDA IDA: Inferred from direct assay	21349253	MGI
involved in negative regulation of T-helper 1 type immune response	IGI IGI: Inferred from genetic interaction	18268038	MGI
involved in negative regulation of immunoglobulin production	IGI IGI: Inferred from genetic interaction	18268038	MGI
involved in negative regulation of inflammatory response to wounding	IDA IDA: Inferred from direct assay	27830702	MGI
involved in negative regulation of leukocyte migration	IGI IGI: Inferred from genetic interaction	18268038	MGI
acts upstream of or within negative regulation of macrophage proliferation	IDA IDA: Inferred from direct assay	26936882	MGI
involved in negative regulation of type II interferon production	IGI IGI: Inferred from genetic interaction	18268038	MGI
acts upstream of or within positive regulation of CD80 production	IDA IDA: Inferred from direct assay	26936882	MGI
acts upstream of or within positive regulation of CD86 production	IDA IDA: Inferred from direct assay	26936882	MGI
acts upstream of or within positive regulation of MHC class I biosynthetic process	IDA IDA: Inferred from direct assay	26936882	MGI
acts upstream of or within positive regulation of MHC class II biosynthetic process	IDA IDA: Inferred from direct assay	26936882	MGI
acts upstream of or within positive regulation of cellular defense response	IMP IMP: Inferred from mutant phenotype	26936882	MGI
involved in positive regulation of chemokine production	IDA IDA: Inferred from direct assay	19841166	MGI
acts upstream of or within positive regulation of gene expression	IDA IDA: Inferred from direct assay	19666510	MGI
involved in positive regulation of immunoglobulin production	IGI IGI: Inferred from genetic interaction	18268038	MGI
involved in positive regulation of inflammatory response	IDA IDA: Inferred from direct assay	19841166	MGI
involved in positive regulation of interleukin-13 production	IGI IGI: Inferred from genetic interaction	18268038	MGI
involved in positive regulation of interleukin-4 production	IGI IGI: Inferred from genetic interaction	18268038	MGI
involved in positive regulation of interleukin-5 production	IGI IGI: Inferred from genetic interaction	18268038	MGI
acts upstream of positive regulation of interleukin-6 production	IDA IDA: Inferred from direct assay	26936882	MGI
acts upstream of or within positive regulation of interleukin-6 production	IDA IDA: Inferred from direct assay	26936882	MGI
involved in positive regulation of interleukin-6 production	IGI IGI: Inferred from genetic interaction	18268038	MGI
acts upstream of or within positive regulation of macrophage activation	IDA IDA: Inferred from direct assay	26936882	MGI
involved in positive regulation of macrophage activation	IDA IDA: Inferred from direct assay	19841166	MGI
acts upstream of or within positive regulation of nitric-oxide synthase biosynthetic process	IDA IDA: Inferred from direct assay	26936882	MGI
acts upstream of or within positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	22660580	MGI
acts upstream of or within positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IGI IGI: Inferred from genetic interaction	22660580	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19841166	MGI
acts upstream of positive regulation of tumor necrosis factor production	IDA IDA: Inferred from direct assay	26936882	MGI
acts upstream of or within positive regulation of tumor necrosis factor production	IDA IDA: Inferred from direct assay	26936882	MGI
acts upstream of or within positive regulation of type 2 immune response	IDA IDA: Inferred from direct assay	23630360	MGI
involved in positive regulation of type 2 immune response	IGI IGI: Inferred from genetic interaction	18268038	MGI
involved in protein import into nucleus	IDA IDA: Inferred from direct assay	32144162	MGI
acts upstream of type 2 immune response	IDA IDA: Inferred from direct assay	23630360	MGI

Cellular Component GO Annotation	Evidence	References	Source
is active in extracellular space	IDA IDA: Inferred from direct assay	27830702	MGI
located in nucleus	IDA IDA: Inferred from direct assay	29045903	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
interleukin-33	nuclear factor from high endothelial venules

Recombinant Il33 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7218	IL-33 Protein, Mouse	Q8BVZ5 (S109-I266)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P700208AF	Animal-Free IL-33 Protein, Mouse (His)	Q8BVZ5 (S109-I266)	≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (5)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99444	Astegolimab	Inhibitor	99.00%	Phase 3
HY-P99673	Itepekimab	Inhibitor	99.496%	Phase 3
HY-P99018	Etokimab	Inhibitor	99.90%	Phase 2
HY-P991633	TQC2938	Inhibitor	/	Phase 2
HY-P991267	CAN10	Inhibitor	95.04%	Phase 1

Pre-clinical Phase

Bioactive Molecules (13)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P2729	Subtilisin	Activator	/	Unkown
HY-114354	BODIPY FL alkyne		98.60%	Unkown
HY-W060417	iST2-1	Inhibitor	99.58%	Unkown
HY-168532	ST2-IN-1	Inhibitor	99.05%	Unkown
HY-163140	BODIPY-phenyl-amide-alkyne		/	Unkown
HY-178144	FPR2 agonist 5		/	Unkown
HY-182370	TKP-5	Degrader	/	Unkown
HY-182693	CPL302-253	Inhibitor	/	Unkown
HY-404647	FK3453	Inhibitor	99.98%	Unkown
HY-RS06757	IL33 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174607	Human IL33 mRNA		/	Unkown
HY-RS16666	Il33 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23101	Il33 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99729	Melrilimab	Inhibitor	96.07%	Unkown
HY-P990669	Torudokimab	Inhibitor	99.72%	Unkown
HY-P992440	PF-06817024	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Il33	NCBI	NCBI:90865