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TRIM26 - tripartite motif containing 26 Gene

Also Known as AFP; RNF95; ZNF173

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7726

About TRIM26

Cytogenetic location: 6p22.1 Genomic coordinates (GRCh38): 6:30,184,455-30,213,406 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 157 orthologues and 80 paralogues. Ubiquitous expression in kidney (RPKM 14.9), spleen (RPKM 12.6) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. Although the function of the protein is unknown, the RING domain suggests that the protein may have DNA-binding activity. The gene localizes to the major histocompatibility complex (MHC) class I region on chromosome 6. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2011]

TRIM26 Products (2)

mRNA	Protein	Name
NM_001242783.2	NP_001229712.1	tripartite motif-containing protein 26
NM_003449.5	NP_003440.1	tripartite motif-containing protein 26

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21516116	GOA
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	29203640	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in innate immune response	IDA IDA: Inferred from direct assay	18248090	GOA
involved in negative regulation of viral entry into host cell	IDA IDA: Inferred from direct assay	18248090	GOA
involved in positive regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	23077300	GOA
involved in positive regulation of non-canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	34017102	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	29203640	GOA
involved in protein K11-linked ubiquitination	IDA IDA: Inferred from direct assay	34017102	GOA
involved in suppression of viral release by host	IDA IDA: Inferred from direct assay	18248090	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in cytoplasm	IDA IDA: Inferred from direct assay	34017102	GOA
is active in nucleus	IDA IDA: Inferred from direct assay	25763818	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRIM26 Protein Structure

zf-C3HC4_4

zf-B_box

0
100
200
248 a.a.

Protein Preferred Names	Protein Names
tripartite motif-containing protein 26	RING finger protein 95

TRIM26 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TRIM26	Q12899	BEND7	Homo sapiens	Q8N7W2-2	Y2H Array	32296183
Intra	TRIM26	Q12899	BEND7	Homo sapiens	Q8N7W2-2	Validated Y2H	32296183
Intra	TRIM26	Q12899	BEND7	Homo sapiens	Q8N7W2-2	Y2H Prey Pooling	32296183
Intra	TRIM26	Q12899	MAGEA6	Homo sapiens	P43360	Y2H Array	32296183
Intra	TRIM26	Q12899	MAGEA6	Homo sapiens	P43360	Y2H	21516116
Intra	TRIM26	Q12899	MAGEA6	Homo sapiens	P43360	Y2H Prey Pooling	32296183
Intra	TRIM26	Q12899	TLE5	Homo sapiens	Q08117-2	Y2H Array	32296183
Intra	TRIM26	Q12899	TLE5	Homo sapiens	Q08117-2	Y2H Prey Pooling	32296183
Intra	TRIM26	Q12899	EPN2	Homo sapiens	O95208-2	Y2H Array	32296183
Intra	TRIM26	Q12899	EPN2	Homo sapiens	O95208-2	Y2H Prey Pooling	32296183
Intra	TRIM26	Q12899	BIVM	Homo sapiens	Q86UB2	Validated Y2H	32296183
Intra	TRIM26	Q12899	BIVM	Homo sapiens	Q86UB2	Y2H Array	32296183
Intra	TRIM26	Q12899	BIVM	Homo sapiens	Q86UB2	Y2H Prey Pooling	32296183
Intra	TRIM26	Q12899	EPN3	Homo sapiens	I6L9I8	Y2H Array	32296183
Intra	TRIM26	Q12899	EPN3	Homo sapiens	I6L9I8	Y2H Prey Pooling	32296183
Intra	TRIM26	Q12899	MACROH2A1	Homo sapiens	O75367	Y2H Prey Pooling	32296183
Intra	TRIM26	Q12899	MACROH2A1	Homo sapiens	O75367	Y2H Array	32296183
Intra	TRIM26	Q12899	TLE5	Homo sapiens	Q08117	Validated Y2H	25416956
Intra	TRIM26	Q12899	THAP1	Homo sapiens	Q9NVV9	Y2H Prey Pooling	25416956
Intra	TRIM26	Q12899	THAP1	Homo sapiens	Q9NVV9	Validated Y2H	25416956
Intra	TRIM26	Q12899	THAP1	Homo sapiens	Q9NVV9	Y2H Prey Pooling	32296183
Intra	TRIM26	Q12899	THAP1	Homo sapiens	Q9NVV9	Validated Y2H	32296183
Intra	TRIM26	Q12899	THAP1	Homo sapiens	Q9NVV9	Y2H Array	25416956
Intra	TRIM26	Q12899	THAP1	Homo sapiens	Q9NVV9	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Neural Tube Defects	Spina Bifida Neural Tube Defect NTD Neural Tube Defects, Susceptibility To Spinal Dysraphism Spina Bifida, Susceptibility To Rachischisis Cleft Spine Open Spine Hydrocele Spinalis Neural Tube Defect Nos Sb - [Spina Bifida] Spinal Hernia Nos Spinal Fissure Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15031	TRIM26 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21959	Trim26 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TRIM26	VGNC	VGNC:78854
Rattus norvegicus	TRIM26	RGD	RGD:1359126
Mus musculus	TRIM26	MGD	MGI:1337056
Others	TRIM26	NCBI