TRIM26 - tripartite motif containing 26 Gene

Homo sapiens

Also known as AFP; RNF95; ZNF173

Gene ID: 7726 | Gene type: protein coding

About TRIM26

Cytogenetic location: 6p22.1 Genomic coordinates (GRCh38): 6:30,184,455-30,213,406 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 157 orthologues and 80 paralogues. Ubiquitous expression in kidney (RPKM 14.9), spleen (RPKM 12.6) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. Although the function of the protein is unknown, the RING domain suggests that the protein may have DNA-binding activity. The gene localizes to the major histocompatibility complex (MHC) class I region on chromosome 6. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2011]

TRIM26 Products(2)

mRNA	Protein	Name
NM_001242783.2	NP_001229712.1	tripartite motif-containing protein 26
NM_003449.5	NP_003440.1	tripartite motif-containing protein 26

TRIM26 Protein Structure

zf-C3HC4_4

zf-B_box

0
100
200
248 a.a.

Protein Preferred Names

Protein Names

tripartite motif-containing protein 26

RING finger protein 95

Related Diseases

Diseases

Alias

Neural Tube Defects

Spina Bifida	Neural Tube Defect
NTD	Neural Tube Defects, Susceptibility To
Spinal Dysraphism	Spina Bifida, Susceptibility To
Rachischisis	Cleft Spine
Open Spine	Hydrocele Spinalis
Neural Tube Defect Nos	Sb - [Spina Bifida]
Spinal Hernia Nos	Spinal Fissure Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15031	TRIM26 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TRIM26	VGNC	VGNC:78854
Rattus norvegicus	TRIM26	RGD	RGD:1359126
Mus musculus	TRIM26	MGD	MGI:1337056

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