NUP85 - nucleoporin 85 Gene

Also Known as Nup75; FROUNT; NPHS17

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 79902

About NUP85

Cytogenetic location: 17q25.1 Genomic coordinates (GRCh38): 17:75,205,679-75,235,758 (from NCBI)

This gene has 25 transcripts (splice variants), 214 orthologues and is associated with 3 phenotypes. Ubiquitous expression in lymph node (RPKM 9.1), testis (RPKM 9.0) and 25 other tissues.

Summary

This gene encodes a protein component of the Nup107-160 subunit of the nuclear pore complex. Nuclear pore complexes are embedded in the nuclear envelope and promote bidirectional transport of macromolecules between the cytoplasm and nucleus. The encoded protein can also bind to the C-terminus of chemokine (C-C motif) receptor 2 (CCR2) and promote chemotaxis of monocytes, thereby participating in the inflammatory response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

NUP85 Products (3)

mRNA	Protein	Name
NM_001303276.2	NP_001290205.1	nuclear pore complex protein Nup85 isoform 2
NM_001330472.2	NP_001317401.1	nuclear pore complex protein Nup85 isoform 3
NM_024844.5	NP_079120.1	nuclear pore complex protein Nup85 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15146057	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in nephron development	IMP IMP: Inferred from mutant phenotype	30179222	GOA

Cellular Component GO Annotation	Evidence	References	Source
colocalizes with kinetochore	IDA IDA: Inferred from direct assay	15146057	GOA
located in nuclear envelope	IDA IDA: Inferred from direct assay	24315095	GOA
part of nuclear pore outer ring	IDA IDA: Inferred from direct assay	15146057	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NUP85 Protein Structure

Nucleopor_Nup85

0
200
400
600
656 a.a.

Protein Preferred Names	Protein Names
nuclear pore complex protein Nup85	nucleoporin 85kDa

NUP85 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NUP85	Q9BW27	CCR2	Homo sapiens	P41597-2	SPR	25283965
Intra	NUP85	Q9BW27	CCR2	Homo sapiens	P41597-2	NMR	25283965
Intra	NUP85	Q9BW27	NUP133	Homo sapiens	Q8WUM0	Affinity Chrom	24315095
Intra	NUP85	Q9BW27	NUP160	Homo sapiens	Q12769	Anti Tag CoIP	30179222
Intra	NUP85	Q9BW27	NUP160	Homo sapiens	Q12769	Affinity Chrom	24315095
Intra	NUP85	Q9BW27	GET4	Homo sapiens	Q7L5D6	Y2H Prey Pooling	32296183
Intra	NUP85	Q9BW27	GET4	Homo sapiens	Q7L5D6	Y2H Array	32296183
Intra	NUP85	Q9BW27	SEH1L	Homo sapiens	Q96EE3	GMS	26391640
Intra	NUP85	Q9BW27	SEH1L	Homo sapiens	Q96EE3	Affinity Chrom	24315095

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Nephrotic Syndrome, Type 17	NPHS17 Nephrotic Syndrome Type 17 Nephrotic Syndrome 17
Seckel Syndrome	Microcephalic Primordial Dwarfism Bird-Headed Dwarfism Harper'S Syndrome Virchow-Seckel Dwarfism Nanocephalic Dwarfism Sckl Seckel-Type Dwarfism
Genetic Steroid-Resistant Nephrotic Syndrome	Familial Idiopathic Steroid-Resistant Nephrotic Syndrome Genetic Srns Hereditary Steroid-Resistant Nephrotic Syndrome Familial Idiopathic Nephrotic Syndrome Nephrotic Syndrome, Steroid-Resistant, Autosomal Recessive Srn1
Nephrotic Syndrome	Finnish Congenital Nephrotic Syndrome Ns - [Nephrotic Syndrome] Nephrosis Syndrome Nephrosis Nos Glomerular Lesion Nephrosis
Seckel Syndrome 8	SCKL8 Seckel Syndrome, Type 8
Focal Segmental Glomerulosclerosis	Familial Idiopathic Steroid-Resistant Nephrotic Syndrome Focal Glomerulosclerosis Fsgs Segmental Glomerulosclerosis Glomerulosclerosis, Focal Segmental Fgs Focal Glomerular Sclerosis Familial Idiopathic Nephrotic Syndrome Focal Sclerosis With Hyalinosis Glomerulosclerosis, Focal Glomerulosclerosis Focal Glomerulosclerosis, Segmental, Focal Focal Segmental Glomerulosclerosis, Not Otherwise Specified
Autoimmune Lymphoproliferative Syndrome	ALPS Canale-Smith Syndrome Autoimmune Lymphoproliferative Syndrome, Type Ia Autoimmune Lymphoproliferative Syndrome, Type Ib Autoimmune Lymphoproliferative Syndrome Type 1, Autosomal Dominant Css Autoimmune Lymphoproliferative Syndrome, Type 1b Autoimmune Lymphoproliferative Syndrome, Type 1a Autoimmune Lymphoproliferative Syndrome, Type I, Autosomal Dominant Fas Deficiency Autoimmune Lymphoproliferative Syndrome 1a ALPS1A Autoimmune Lymphoproliferative Syndrome Type Ia Autoimmune Lymphoproliferative Syndrome 1b ALPS1B Autoimmune Lymphoproliferative Syndrome Type Ib
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly
Primary Autosomal Recessive Microcephaly	Autosomal Recessive Primary Microcephaly Mcph True Microcephaly Microcephalia Vera Microcephaly Vera Microcephaly Primary Hereditary Microcephaly, Primary, Autosomal Recessive Primary Microcephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09698	NUP85 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21676	Nup85 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28194	Nup85 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	NUP85	RGD	RGD:1311942
Macaca mulatta	NUP85	VGNC	VGNC:75591
Bos taurus	NUP85	VGNC	VGNC:32364
Canis familiaris	NUP85	VGNC	VGNC:44060
Felis catus	NUP85	VGNC	VGNC:68728
Mus musculus	NUP85	MGD	MGI:3046173
Others	NUP85	NCBI