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GET4 - guided entry of tail-anchored proteins factor 4 Gene

Also Known as CEE; TRC35; CGI-20; C7orf20

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51608

About GET4

Cytogenetic location: 7p22.3 Genomic coordinates (GRCh38): 7:876,554-896,436 (from NCBI)

This gene has 7 transcripts (splice variants) and 205 orthologues. Ubiquitous expression in testis (RPKM 20.0), adrenal (RPKM 15.8) and 25 other tissues.

Summary

Enables chaperone binding activity. Involved in cytoplasmic sequestering of protein; maintenance of unfolded protein involved in ERAD pathway; and tail-anchored membrane protein insertion into ER membrane. Located in chromosome; cytosol; and nuclear lumen. Part of BAT3 complex. [provided by Alliance of Genome Resources, Apr 2022]

GET4 Products (1)

mRNA	Protein	Name
NM_015949.3	NP_057033.2	Golgi to ER traffic protein 4 homolog

GET4 Protein Structure

DUF410

0
100
200
300
327 a.a.

Protein Preferred Names	Protein Names
Golgi to ER traffic protein 4 homolog	H_NH1244M04.5

GET4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	GET4	Q7L5D6	KRTAP9-3	Homo sapiens	Q9BYQ3	Validated Y2H	32296183
Intra	GET4	Q7L5D6	PRKAB2	Homo sapiens	O43741	Y2H Prey Pooling	25416956
Intra	GET4	Q7L5D6	PRKAB2	Homo sapiens	O43741	Y2H Array	25416956
Intra	GET4	Q7L5D6	PRKAB2	Homo sapiens	O43741	Y2H	21516116
Intra	GET4	Q7L5D6	BAG6	Homo sapiens	P46379-2	Anti Tag CoIP	28514442
Intra	GET4	Q7L5D6	FBN1	Homo sapiens	P35555	Y2H Prey Pooling	32296183
Intra	GET4	Q7L5D6	GET3	Homo sapiens	O43681	Anti Tag CoIP	33961781
Intra	GET4	Q7L5D6	NUP85	Homo sapiens	Q9BW27	Validated Y2H	32296183
Intra	GET4	Q7L5D6	DUSP21	Homo sapiens	Q9H596	Validated Y2H	32296183
Intra	GET4	Q7L5D6	ENKD1	Homo sapiens	Q9H0I2	Validated Y2H	32296183
Intra	GET4	Q7L5D6	AIRIM	Homo sapiens	Q9NX04	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Louping Ill
Hypotrichosis 2	HYPT2 Hypotrichosis Simplex Of The Scalp 1 Htss1 Htss Hypotrichosis, Spanish Type Spanish Type Hypotrichosis Hypotrichosis Spanish Type Hypotrichosis, Type 2 Hypotrichosis Simplex Of Scalp
Eastern Equine Encephalitis	Eee Neuroinvasive Eastern Equine Encephalitis Virus Infection Eastern Equine Encephalomyelitis Encephalomyelitis, Eastern Equine Triple E Eastern Equine Encephalitis Virus Infection Neuroinvasive Eastern Equine Encephalitis Virus Disease Eee - [Eastern Equine Encephalitis]
Saethre-Chotzen Syndrome	SCS Acs3 Acs Iii Chotzen Syndrome Acrocephaly, Skull Asymmetry, And Mild Syndactyly Acrocephalosyndactyly Type 3 Acrocephalosyndactyly, Type Iii Acrocephalosyndactyly Type Iii Saethre-Chotzen Syndrome With Or Without Eyelid Anomalies Auralcephalosyndactyly Acs 3 Acrocephalo-Syndactyly, Type 3 Blepharophimosis,Epicanthus Inversus, And Ptosis 3 Aural Cephalosyndactyly Kurczynski-Casperson Syndrome Acrocephalosyndactyly Iii Dysostosis Craniofacialis With Hypertelorism Saethre-Chotzen Syndrome, With/Without Eyelid Anomalies Sakati Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05375	GET4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown