Cblc - Casitas B-lineage lymphoma c Gene

Also Known as Cbl3; 2310076I21Rik; 2310079L19Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 80794

Summary

Predicted to enable several functions, including SH3 domain binding activity; phosphotyrosine residue binding activity; and signaling receptor binding activity. Predicted to be involved in cellular protein metabolic process; negative regulation of protein kinase activity; and signal transduction. Predicted to be part of ubiquitin Ligase complex. Predicted to be active in membrane raft and plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; lung; and sensory organ. Orthologous to human CBLC (Cbl proto-oncogene C). [provided by Alliance of Genome Resources, Apr 2022]

Cblc Products (2)

mRNA Protein Name
NM_001161844.1 NP_001155316.1 E3 ubiquitin-protein ligase CBL-C isoform 2
NM_023224.5 NP_075713.3 E3 ubiquitin-protein ligase CBL-C isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18753381 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of neuron apoptotic process IDA
IDA: Inferred from direct assay
18753381 MGI
acts upstream of or within protein catabolic process IDA
IDA: Inferred from direct assay
18753381 MGI
acts upstream of or within protein stabilization IDA
IDA: Inferred from direct assay
18753381 MGI
acts upstream of or within response to glial cell derived neurotrophic factor IDA
IDA: Inferred from direct assay
18753381 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase CBL-C

  • CBL-3

  • RING-type E3 ubiquitin transferase CBL-C

  • SH3-binding protein CBL-3

  • SH3-binding protein CBL-C

  • signal transduction protein CBL-C

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B2209 Hydroxocobalamin 99.32% Yes

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-107643 Reversan Inhibitor 99.57% Unkown
HY-154992 2,4-Difluorophenylethynylcobalamin 98.97% Unkown
HY-124922 CBLC100 / Unkown
HY-RS01998 CBLC Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08509 MMACHC Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19579 Cblc Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26076 Cblc Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cblc NCBI NCBI:23624