2. Gene
  3. Mapk14 - mitogen activated protein kinase 14 Gene

Mapk14 - mitogen activated protein kinase 14 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as RK; Hog; p38; CRK1; CSBP; Exip; Mxi2; CSPB1; Csbp1; Csbp2; Prkm14; Prkm15; Sapk2A; p38Hog; p38alpha

Gene ID: 81649 | Gene type: protein coding

About Mapk14

Primary_assembly 20: 6,749,670-6,810,589 forward strand.mRatBN7.2:CM026993.1

This gene has 6 transcripts (splice variants), 295 orthologues, 21 paralogues and is associated with 36 phenotypes. Biased expression in Kidney (RPKM 267.1), Adrenal (RPKM 258.5) and 9 other tissues.

Summary

Enables ATP binding activity; MAP kinase activity; and protein C-terminus binding activity. Involved in several processes, including protein autophosphorylation; response to glucose; and stress-activated MAPK cascade. Located in cytosol and nucleus. Used to study diabetic neuropathy and osteoporosis. Biomarker of Alzheimer's disease and anti-basement membrane glomerulonephritis. Orthologous to human MAPK14 (mitogen-activated protein kinase 14). [provided by Alliance of Genome Resources, Apr 2022]

Mapk14 Products(1)

mRNA Protein Name
NM_031020.3 NP_112282.2 mitogen-activated protein kinase 14

Mapk14 Protein Structure

STKc_p38alpha

STKc_p38alpha: cd07877 (5 - 349)

  • 0
  • 100
  • 200
  • 300
  • 360 a.a.
Protein Preferred Names Protein Names

mitogen-activated protein kinase 14

Csaids binding protein

MAP kinase 14

MAP kinase 2

MAP kinase Mxi2

MAP kinase p38 alpha

MAPK 14

MAX-interacting protein 2

cytokine suppressive anti-inflammatory drug binding protein

cytokine-supressive anti-inflammatory drug binding protein

mitogen-activated protein kinase 14A

mitogen-activated protein kinase p38 alpha

p38 MAP kinase

p38 mitogen activated protein kinase

p38alpha Exip

reactive kinase

stress-activated protein kinase 2A

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-10401 VX-702 Inhibitor 99.54% Phase 2
Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-18874 p38-α MAPK-IN-1 Inhibitor 99.89% Unkown
HY-148061 DB1113 99.28% Unkown
HY-RS08107 MAPK14 Human Pre-designed siRNA Set A / Unkown
HY-RS08108 Mapk14 Mouse Pre-designed siRNA Set A / Unkown
HY-RS08109 Mapk14 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mapk14 NCBI NCBI:1432