Mapk14 - mitogen activated protein kinase 14 Gene

Also Known as RK; Hog; p38; CRK1; CSBP; Exip; Mxi2; CSPB1; Csbp1; Csbp2; Prkm14; Prkm15; Sapk2A; p38Hog; p38alpha

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 81649

About Mapk14

Primary_assembly 20: 6,749,670-6,810,589 forward strand.mRatBN7.2:CM026993.1

This gene has 6 transcripts (splice variants), 295 orthologues, 21 paralogues and is associated with 36 phenotypes. Biased expression in Kidney (RPKM 267.1), Adrenal (RPKM 258.5) and 9 other tissues.

Summary

Enables ATP binding activity; MAP kinase activity; and protein C-terminus binding activity. Involved in several processes, including protein autophosphorylation; response to glucose; and stress-activated MAPK cascade. Located in cytosol and nucleus. Used to study diabetic neuropathy and osteoporosis. Biomarker of Alzheimer's disease and anti-basement membrane glomerulonephritis. Orthologous to human MAPK14 (mitogen-activated protein kinase 14). [provided by Alliance of Genome Resources, Apr 2022]

Mapk14 Products (1)

mRNA Protein Name
NM_031020.3 NP_112282.2 mitogen-activated protein kinase 14

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
16879317 RGD
enables MAP kinase activity IDA
IDA: Inferred from direct assay
16407200 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
21607062 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to transforming growth factor beta stimulus IEP
IEP: Inferred from expression pattern
33409963 RGD
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
23589286 RGD
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
16407200 RGD
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
16407200 RGD
involved in response to glucose IEP
IEP: Inferred from expression pattern
18579738 RGD
involved in stress-activated MAPK cascade IDA
IDA: Inferred from direct assay
16407200 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mapk14 Protein Structure

STKc_p38alpha

STKc_p38alpha: cd07877 (5 - 349)

  • 0
  • 100
  • 200
  • 300
  • 360 a.a.
Protein Preferred Names Protein Names

mitogen-activated protein kinase 14

  • Csaids binding protein

  • MAP kinase 14

  • MAP kinase 2

  • MAP kinase Mxi2

  • MAP kinase p38 alpha

  • MAPK 14

  • MAX-interacting protein 2

  • cytokine suppressive anti-inflammatory drug binding protein

  • cytokine-supressive anti-inflammatory drug binding protein

  • mitogen-activated protein kinase 14A

  • mitogen-activated protein kinase p38 alpha

  • p38 MAP kinase

  • p38 mitogen activated protein kinase

  • p38alpha Exip

  • reactive kinase

  • stress-activated protein kinase 2A

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-10401 VX-702 Inhibitor 99.69% Phase 2

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N7922 Urolithin M5 Inhibitor 97.31% Unkown
HY-123961 SJF-8240 Degrader 99.33% Unkown
HY-18874 p38-α MAPK-IN-1 Inhibitor 99.71% Unkown
HY-148061 DB1113 99.86% Unkown
HY-148063 DB0614 99.92% Unkown
HY-RS08108 Mapk14 Mouse Pre-designed siRNA Set A / Unkown
HY-RS08107 MAPK14 Human Pre-designed siRNA Set A / Unkown
HY-186241 NuP-3 Inhibitor / Unkown
HY-N18209 4-Hydroxy-3-butylphthalide / Unkown
HY-RS08109 Mapk14 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mapk14 NCBI NCBI:1432