Rpl5 - ribosomal protein L5 Gene

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 81763

Summary

Enables 5S rRNA binding activity and mRNA binding activity. Involved in cellular response to inorganic substance; positive regulation of aminoacyl-tRNA Ligase activity; and positive regulation of Phosphatase activity. Located in cytosolic ribosome. Part of Aminoacyl-tRNA Synthetase multienzyme complex and cytosolic large ribosomal subunit. Is active in postsynaptic density. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 6; T-cell acute lymphoblastic leukemia; and glioblastoma. Orthologous to human RPL5 (ribosomal protein L5). [provided by Alliance of Genome Resources, Apr 2022]

Rpl5 Products (1)

mRNA	Protein	Name
NM_031099.1	NP_112361.1	60S ribosomal protein L5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables 5S rRNA binding	IDA IDA: Inferred from direct assay	6430881	RGD
enables mRNA binding	IDA IDA: Inferred from direct assay	7338522	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	7649987	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of phosphatase activity	IDA IDA: Inferred from direct assay	7649987	RGD

Cellular Component GO Annotation	Evidence	References	Source
part of aminoacyl-tRNA synthetase multienzyme complex	IDA IDA: Inferred from direct assay	8982850	RGD
part of cytosolic large ribosomal subunit	IDA IDA: Inferred from direct assay	3988767	RGD
located in cytosolic ribosome	IDA IDA: Inferred from direct assay	3733691	RGD
is active in postsynaptic density	EXP EXP: Inferred from Experiment	15020595	RGD
is active in postsynaptic density	IDA IDA: Inferred from direct assay	15020595	RGD
part of ribonucleoprotein complex	IDA IDA: Inferred from direct assay	1665486	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
60S ribosomal protein L5

Rpl5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Rpl5	P09895	Ppp1cb	Rattus norvegicus	P62142	Cosedimentation	7649987

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12201	RPL5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rpl5	NCBI	NCBI:6125