Mchr1 - melanin-concentrating hormone receptor 1 Gene

Also Known as Slc1; Gpr24; Mch-1r

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 83567

About Mchr1

Primary_assembly 7: 112,761,554-112,764,032 forward strand.mRatBN7.2:CM026980.1

This gene has 1 transcript (splice variant), 241 orthologues, 50 paralogues and is associated with 3 phenotypes. Biased expression in Brain (RPKM 31.9), Muscle (RPKM 4.3) and 2 other tissues.

Summary

Enables hormone binding activity; melanin-concentrating hormone receptor activity; and protein C-terminus binding activity. Involved in cell surface receptor signaling pathway; positive regulation of calcium ion transport; and positive regulation of cytosolic calcium ion concentration. Located in plasma membrane. Biomarker of obesity. Human ortholog(s) of this gene implicated in morbid obesity. Orthologous to human MCHR1 (melanin concentrating hormone receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Mchr1 Products (1)

mRNA Protein Name
NM_031758.1 NP_113946.1 melanin-concentrating hormone receptor 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables hormone binding IDA
IDA: Inferred from direct assay
12505154 RGD
enables melanin-concentrating hormone receptor activity IDA
IDA: Inferred from direct assay
12505154 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
16945926 RGD
Biological Process GO Annotation Evidence References Source
involved in cell surface receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
15117878 RGD
involved in positive regulation of calcium ion transport IMP
IMP: Inferred from mutant phenotype
15117878 RGD
involved in positive regulation of cytosolic calcium ion concentration IMP
IMP: Inferred from mutant phenotype
10559938 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mchr1 Protein Structure

7tmA_MCHR1

7tmA_MCHR1: cd15338 (40 - 321)

7tmA_MCHR1

7tmA_MCHR1: cd15338 (41 - 67)

7tmA_MCHR1

7tmA_MCHR1: cd15338 (77 - 103)

7tmA_MCHR1

7tmA_MCHR1: cd15338 (115 - 145)

7tmA_MCHR1

7tmA_MCHR1: cd15338 (157 - 177)

7tmA_MCHR1

7tmA_MCHR1: cd15338 (204 - 233)

7tmA_MCHR1

7tmA_MCHR1: cd15338 (248 - 278)

7tmA_MCHR1

7tmA_MCHR1: cd15338 (289 - 314)

  • 0
  • 100
  • 200
  • 300
  • 353 a.a.
Protein Preferred Names Protein Names

melanin-concentrating hormone receptor 1

  • G-protein coupled receptor 24

  • MCH receptor 1

  • MCH-R1

  • MCH1R

  • MCHR

  • MCHR-1

  • SLC-1

  • somatostatin receptor-like protein

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-U00257 AZD1979 Antagonist 99.59% Phase 1
HY-100318 MCHR1 antagonist 5 Antagonist 99.61% Phase 1
HY-12433A BMS-830216 Antagonist / Phase 1

Pre-clinical Phase

Bioactive Molecules (23)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P1205A MCH(human, mouse, rat) TFA Ligand 99.09% Unkown
HY-107625A SNAP 94847 hydrochloride Inhibitor 99.90% Unkown
HY-100321 MCHR1 antagonist 2 98.27% Unkown
HY-108049 GW856464 Antagonist 99.83% Unkown
HY-12433 BMS-819881 99.78% Unkown
HY-P1204 [Ala17]-MCH Agonist 98.28% Unkown
HY-RS08225 MCHR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-107626 ATC0065 Antagonist 99.09% Unkown
HY-101699 AMG-076 free base Antagonist / Unkown
HY-107625 SNAP 94847 Antagonist / Unkown
HY-107626A ATC0065 free base Antagonist / Unkown
HY-116031 ATC0175 free base Antagonist / Unkown
HY-119015 MCHR1 antagonist 6 Antagonist / Unkown
HY-120608 BMS-814580 Inhibitor / Unkown
HY-120847 BI 186908 Antagonist / Unkown
HY-136152 MCHR1 antagonist 3 Antagonist / Unkown
HY-161899 MCHR1 antagonist 4 Antagonist / Unkown
HY-185478 NGD-4715 Antagonist / Unkown
HY-P1204A [Ala17]-MCH TFA Agonist / Unkown
HY-RS08226 Mchr1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08227 Mchr1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-101699A AMG-076 Antagonist / Unkown
HY-U00353 MCHR1 antagonist 1 Antagonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mchr1 NCBI NCBI:2847