GLYR1 - glyoxylate reductase 1 homolog Gene

Also Known as NP60; NPAC; hNDF; BM045; HIBDL; N-PAC

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84656

About GLYR1

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:4,803,203-4,847,288 (from NCBI)

This gene has 13 transcripts (splice variants), 207 orthologues and 1 paralogue. Ubiquitous expression in kidney (RPKM 24.0), brain (RPKM 23.5) and 25 other tissues.

Summary

Enables DNA binding activity; methylated histone binding activity; and nucleosome binding activity. Involved in positive regulation of histone acetylation and positive regulation of transcription by RNA polymerase II. Located in cytosol and nucleoplasm. Part of nucleosome. [provided by Alliance of Genome Resources, Apr 2022]

GLYR1 Products (5)

mRNA Protein Name
NM_001308096.2 NP_001295025.1 cytokine-like nuclear factor N-PAC isoform 2
NM_001324096.2 NP_001311025.2 cytokine-like nuclear factor N-PAC isoform 3
NM_001324097.2 NP_001311026.2 cytokine-like nuclear factor N-PAC isoform 4
NM_001324098.2 NP_001311027.2 cytokine-like nuclear factor N-PAC isoform 5
NM_032569.4 NP_115958.2 cytokine-like nuclear factor N-PAC isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
29759984 GOA
enables chromatin binding IDA
IDA: Inferred from direct assay
29759984 GOA
enables chromatin-protein adaptor activity IDA
IDA: Inferred from direct assay
30970244 GOA
enables histone binding IDA
IDA: Inferred from direct assay
23260659 GOA
enables methylated histone binding IDA
IDA: Inferred from direct assay
20850016 GOA
enables nucleosome binding IDA
IDA: Inferred from direct assay
29759984 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
23260659 GOA
Biological Process GO Annotation Evidence References Source
involved in transcription elongation-coupled chromatin remodeling IDA
IDA: Inferred from direct assay
29759984 GOA
involved in transcription initiation-coupled chromatin remodeling IDA
IDA: Inferred from direct assay
30970244 GOA
Cellular Component GO Annotation Evidence References Source
located in chromatin IDA
IDA: Inferred from direct assay
30970244 GOA
part of nucleosome IDA
IDA: Inferred from direct assay
23260659 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GLYR1 Protein Structure

PWWP

PWWP: PWWP domain (7 - 88)

NAD_binding_2

NAD_binding_2: NAD binding domain of 6-phosphogluconate dehydrogenase (268 - 428)

NAD_binding_11

NAD_binding_11: NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase (431 - 551)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 553 a.a.
Protein Preferred Names Protein Names

cytokine-like nuclear factor N-PAC

  • 3-hydroxyisobutyrate dehydrogenase-like protein

GLYR1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GLYR1 Q49A26 CCNC Homo sapiens P24863
Validated Y2H
25416956
Intra
GLYR1 Q49A26 CCNC Homo sapiens P24863
Y2H Array
25416956
Intra
GLYR1 Q49A26 FHL2 Homo sapiens Q14192
Y2H Array
31515488
Intra
GLYR1 Q49A26 CFAP206 Homo sapiens Q8IYR0
Y2H Prey Pooling
25416956
Intra
GLYR1 Q49A26 CFAP206 Homo sapiens Q8IYR0
Y2H Array
25416956
Intra
GLYR1 Q49A26 EIF1AD Homo sapiens Q8N9N8
Y2H Array
31515488
Intra
GLYR1 Q49A26 EIF1AD Homo sapiens Q8N9N8
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Retinitis Pigmentosa 47

  • RP47

  • Retinitis Pigmentosa, Type 47
Ritscher-Schinzel Syndrome

  • 3c Syndrome

  • Ccc Dysplasia

  • Craniocerebellocardiac Dysplasia

  • Cranio-Cerebello-Cardiac Dysplasia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-41700 D-Alanine 99.92% Unkown
HY-161246 uPSEM792 Agonist 98.02% Unkown
HY-RS05512 GLYR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-41700S2 D-Alanine-d1 / Unkown
HY-41700S5 D-Alanine-13C3 / Unkown
HY-RS22530 Glyr1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29050 Glyr1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus GLYR1 VGNC VGNC:29430
Canis familiaris GLYR1 VGNC VGNC:41284
Macaca mulatta GLYR1 VGNC VGNC:99510
Rattus norvegicus GLYR1 RGD RGD:1309459
Mus musculus GLYR1 MGD MGI:1921272
Felis catus GLYR1 VGNC VGNC:62602
Others GLYR1 NCBI