Nox4 - NADPH oxidase 4 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 85431

About Nox4

Primary_assembly 1: 140,901,097-141,077,406 forward strand.mRatBN7.2:CM026974.1

This gene has 3 transcripts (splice variants), 149 orthologues, 5 paralogues and is associated with 20 phenotypes. Biased expression in Kidney (RPKM 64.2), Lung (RPKM 75.7) and 1 other tissue.

Summary

Enables NAD(P)H oxidase H2O2-forming activity. Involved in several processes, including cellular response to cAMP; cellular response to gamma radiation; and positive regulation of stress fiber assembly. Located in several cellular components, including apical plasma membrane; focal adhesion; and perinuclear endoplasmic reticulum. Part of NADPH Oxidase complex. Colocalizes with stress fiber. Used to study hypertension. Biomarker of hypertension and non-alcoholic steatohepatitis. Orthologous to human NOX4 (NADPH Oxidase 4). [provided by Alliance of Genome Resources, Apr 2022]

Nox4 Products (1)

mRNA Protein Name
NM_053524.1 NP_445976.1 NADPH oxidase 4

Nox4 Protein Structure

Ferric_reduct

Ferric_reduct: pfam01794 (68 - 204)

NOX_Duox_like_FAD_NADP

NOX_Duox_like_FAD_NADP: cd06186 (310 - 621)

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  • 500
  • 623 a.a.
Protein Preferred Names Protein Names

NADPH oxidase 4

  • kidney oxidase-1

  • kidney superoxide-producing NADPH oxidase

  • kox-1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-12298 Setanaxib Inhibitor 99.81% Phase 2
HY-120801A APX-115 free base Inhibitor 99.54% Phase 2

Pre-clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-100111 GLX351322 Inhibitor 99.15% Unkown
HY-120801 APX-115 Inhibitor 99.90% Unkown
HY-101499 GKT136901 Inhibitor 99.33% Unkown
HY-152026 NADPH oxidase-IN-1 Inhibitor 99.69% Unkown
HY-N3239 Mulberrofuran G Inhibitor 97.86% Unkown
HY-105946 Hidrosmin Inhibitor 95.34% Unkown
HY-174817 NOX5-IN-1 Inhibitor / Unkown
HY-N9097 Niazirin Inhibitor 99.9% Unkown
HY-174818 NOX5-IN-2 Inhibitor / Unkown
HY-124487 GK-136901 Inhibitor / Unkown
HY-148936 GLX481372 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nox4 NCBI NCBI:50507