2. Gene
  3. Nox4 - NADPH oxidase 4 Gene

Nox4 - NADPH oxidase 4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 85431 | Gene type: protein coding

About Nox4

Primary_assembly 1: 140,901,097-141,077,406 forward strand.mRatBN7.2:CM026974.1

This gene has 3 transcripts (splice variants), 149 orthologues, 5 paralogues and is associated with 20 phenotypes. Biased expression in Kidney (RPKM 64.2), Lung (RPKM 75.7) and 1 other tissue.

Summary

Enables NAD(P)H oxidase H2O2-forming activity. Involved in several processes, including cellular response to cAMP; cellular response to gamma radiation; and positive regulation of stress fiber assembly. Located in several cellular components, including apical plasma membrane; focal adhesion; and perinuclear endoplasmic reticulum. Part of NADPH Oxidase complex. Colocalizes with stress fiber. Used to study hypertension. Biomarker of hypertension and non-alcoholic steatohepatitis. Orthologous to human NOX4 (NADPH Oxidase 4). [provided by Alliance of Genome Resources, Apr 2022]

Nox4 Products(1)

mRNA Protein Name
NM_053524.1 NP_445976.1 NADPH oxidase 4

Nox4 Protein Structure

Ferric_reduct

Ferric_reduct: pfam01794 (68 - 204)

NOX_Duox_like_FAD_NADP

NOX_Duox_like_FAD_NADP: cd06186 (310 - 621)

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  • 623 a.a.
Protein Preferred Names Protein Names

NADPH oxidase 4

kidney oxidase-1

kidney superoxide-producing NADPH oxidase

kox-1

Related Agents

Clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-12298 Setanaxib Inhibitor 99.45% Phase 3
HY-120801 APX-115 Inhibitor 99.58% Phase 2
HY-120801A APX-115 free base Inhibitor 98.11% Phase 2
Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-100111 GLX351322 Inhibitor 99.67% Unkown
HY-N3239 Mulberrofuran G Inhibitor 99.84% Unkown
HY-152026 NADPH oxidase-IN-1 Inhibitor 99.60% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nox4 NCBI NCBI:50507