DPP9 - dipeptidyl peptidase 9 Gene

Also Known as DP9; DPLP9; DPRP2; DPP IX; DPRP-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 91039

About DPP9

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:4,675,227-4,723,842 (from NCBI)

This gene has 29 transcripts (splice variants), 255 orthologues, 6 paralogues and is associated with 1 phenotype. Ubiquitous expression in spleen (RPKM 7.8), appendix (RPKM 7.5) and 25 other tissues.

Summary

This gene encodes a protein that is a member of the S9B family in clan SC of the serine proteases. The protein has been shown to have post-proline dipeptidyl Aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Although the activity of this protein is similar to that of Dipeptidyl Peptidase 4 (DPP4), it does not appear to be membrane bound. In general, dipeptidyl peptidases appear to be involved in the regulation of the activity of their substrates and have been linked to a variety of diseases including type 2 diabetes, obesity and Cancer. Several transcript variants of this gene have been described but not fully characterized. [provided by RefSeq, Jul 2008]

DPP9 Products (30)

mRNA Protein Name
NM_001365987.2 NP_001352916.1 dipeptidyl peptidase 9 isoform 2
NM_001384611.1 NP_001371540.1 dipeptidyl peptidase 9 isoform 1
NM_001384612.1 NP_001371541.1 dipeptidyl peptidase 9 isoform 1
NM_001384613.1 NP_001371542.1 dipeptidyl peptidase 9 isoform 1
NM_001384614.1 NP_001371543.1 dipeptidyl peptidase 9 isoform 1
NM_001384615.1 NP_001371544.1 dipeptidyl peptidase 9 isoform 1
NM_001384616.1 NP_001371545.1 dipeptidyl peptidase 9 isoform 2
NM_001384617.1 NP_001371546.1 dipeptidyl peptidase 9 isoform 3
NM_001384618.1 NP_001371547.1 dipeptidyl peptidase 9 isoform 4
NM_001384619.1 NP_001371548.1 dipeptidyl peptidase 9 isoform 5
NM_001384620.1 NP_001371549.1 dipeptidyl peptidase 9 isoform 6
NM_001384621.1 NP_001371550.1 dipeptidyl peptidase 9 isoform 6
NM_001384622.1 NP_001371551.1 dipeptidyl peptidase 9 isoform 15
NM_001384623.1 NP_001371552.1 dipeptidyl peptidase 9 isoform 7
NM_001384624.1 NP_001371553.1 dipeptidyl peptidase 9 isoform 7
NM_001384625.1 NP_001371554.1 dipeptidyl peptidase 9 isoform 7
NM_001384626.1 NP_001371555.1 dipeptidyl peptidase 9 isoform 7
NM_001384627.1 NP_001371556.1 dipeptidyl peptidase 9 isoform 7
NM_001384628.1 NP_001371557.1 dipeptidyl peptidase 9 isoform 8
NM_001384629.1 NP_001371558.1 dipeptidyl peptidase 9 isoform 8
NM_001384630.1 NP_001371559.1 dipeptidyl peptidase 9 isoform 9
NM_001384631.1 NP_001371560.1 dipeptidyl peptidase 9 isoform 10
NM_001384632.1 NP_001371561.1 dipeptidyl peptidase 9 isoform 11
NM_001384633.1 NP_001371562.1 dipeptidyl peptidase 9 isoform 11
NM_001384634.1 NP_001371563.1 dipeptidyl peptidase 9 isoform 12
NM_001384635.1 NP_001371564.1 dipeptidyl peptidase 9 isoform 13
NM_001384636.1 NP_001371565.1 dipeptidyl peptidase 9 isoform 14
NM_001384637.1 NP_001371566.1 dipeptidyl peptidase 9 isoform 14
NM_001384638.1 NP_001371567.1 dipeptidyl peptidase 9 isoform 14
NM_139159.5 NP_631898.3 dipeptidyl peptidase 9 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables dipeptidyl-peptidase activity IDA
IDA: Inferred from direct assay
19667070 GOA
enables dipeptidyl-peptidase activity IMP
IMP: Inferred from mutant phenotype
36112693 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
22001206 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
30291141 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of programmed cell death IDA
IDA: Inferred from direct assay
31525884 GOA
acts upstream of negative effect pyroptotic inflammatory response IDA
IDA: Inferred from direct assay
33731929 GOA
Cellular Component GO Annotation Evidence References Source
located in cell leading edge IDA
IDA: Inferred from direct assay
25486458 GOA
is active in cytosol IDA
IDA: Inferred from direct assay
15245913 GOA
located in microtubule IDA
IDA: Inferred from direct assay
25486458 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DPP9 Protein Structure

DPPIV_N

DPPIV_N: Dipeptidyl peptidase IV (DPP IV) N-terminal region (146 - 570)

Peptidase_S9

Peptidase_S9: Prolyl oligopeptidase family (663 - 863)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 863 a.a.
Protein Preferred Names Protein Names

dipeptidyl peptidase 9

  • dipeptidyl peptidase IV-related protein-2

DPP9 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
DPP9 Q86TI2 DPP9 Homo sapiens Q86TI2
CD
22001206
Intra
DPP9 Q86TI2 DPP9 Homo sapiens Q86TI2
Solution Sedimentation
22001206
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Interstitial Lung Disease 2

  • Idiopathic Pulmonary Fibrosis

  • Ipf

  • Fibrocystic Pulmonary Dysplasia

  • Pulmonary Fibrosis, Idiopathic

  • Pulmonary Fibrosis, Idiopathic, Susceptibility To

  • Cryptogenic Fibrosing Alveolitis

  • ILD2

  • Idiopathic Pulmonary Fibrosis, Familial

  • Fibrosing Alveolitis, Cryptogenic

  • Uip

  • Fibrosing Alveolitis

  • Interstitial Pneumonitis, Usual

  • Familial Idiopathic Pulmonary Fibrosis

  • Idiopathic Fibrosing Alveolitis, Chronic Form

  • Usual Interstitial Pneumonia

  • Fibrosing Alveolitis Cryptogenic

  • Hamman-Rich Disease

  • Idiopathic Pulmonary Fibrosis Familial

  • Interstitial Pneumonitis Usual

  • Fibrosis Idiopathic Pulmonary

  • Fibrosis, Pulmonary, Idiopathic

  • Hamman-Rich Syndrome

  • Chronic Idiopathic Pulmonary Fibrosis

  • Acute Interstitial Pneumonia

  • Interstitial Pulmonary Fibrosis

  • Ipf - [Idiopathic Pulmonary Fibrosis]

  • Idiopathic Lung Fibrosis

  • Fibrosing Lung Disease

  • Pulmonary Fibrosis Nos

  • Fibrosing Pneumonitis
Nasopharyngitis

  • Chronic Nasopharyngitis

  • Chronic Rhinopharyngitis
Scoliosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-A0023A Alogliptin Inhibitor 99.93% Unkown
HY-A0023 Alogliptin Benzoate Inhibitor 99.98% Unkown

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-12528 DBPR108 Inhibitor 99.93% Phase 3
HY-16656 BMS-767778 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (16)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-116304 1G244 98.50% Unkown
HY-P4344 Met-Gly-Pro-AMC Substrate 99.74% Unkown
HY-A0023AS1 Alogliptin-d3 Inhibitor 99.61% Unkown
HY-151871 ICeD-2 Inhibitor / Unkown
HY-A0023AS2 Alogliptin-13C,d3 benzoate Inhibitor 98.77% Unkown
HY-172529 DPP9-IN-1 Inhibitor / Unkown
HY-176000 Sulphostin Inhibitor / Unkown
HY-176001 DPP8/9-IN-1 Inhibitor / Unkown
HY-179348 DPP9-IN-2 / Unkown
HY-P11823 FAPα/DPP4 flurogenic substrate-1 / Unkown
HY-RS03969 DPP9 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-151871A cis-ICeD-2 Inhibitor / Unkown
HY-175226 DPP8/9-IN-2 Inhibitor / Unkown
HY-RS16887 Dpp9 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23329 Dpp9 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-U00346A TS-021 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus DPP9 VGNC VGNC:28190
Rattus norvegicus DPP9 RGD RGD:1588575
Mus musculus DPP9 MGD MGI:2443967
Macaca mulatta DPP9 VGNC VGNC:109618
Canis familiaris DPP9 VGNC VGNC:40078
Felis catus DPP9 VGNC VGNC:61607
Others DPP9 NCBI