IMP4 - IMP U3 small nucleolar ribonucleoprotein 4 Gene

Also Known as BXDC4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 92856

About IMP4

Cytogenetic location: 2q21.1 Genomic coordinates (GRCh38): 2:130,342,897-130,347,967 (from NCBI)

This gene has 17 transcripts (splice variants), 200 orthologues and 1 paralogue. Ubiquitous expression in lymph node (RPKM 11.8), appendix (RPKM 9.3) and 25 other tissues.

Summary

The protein encoded by this gene, along with IMP3 and MPP10, is part of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP) complex. This complex is necessary for the early cleavage steps of pre-18S ribosomal RNA processing. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]

IMP4 Products (16)

mRNA Protein Name
NM_001320304.2 NP_001307233.1 U3 small nucleolar ribonucleoprotein protein IMP4 isoform b
NM_001320305.2 NP_001307234.1 U3 small nucleolar ribonucleoprotein protein IMP4 isoform c
NM_001320306.2 NP_001307235.1 U3 small nucleolar ribonucleoprotein protein IMP4 isoform d
NM_001320307.2 NP_001307236.1 U3 small nucleolar ribonucleoprotein protein IMP4 isoform d
NM_001320309.2 NP_001307238.1 U3 small nucleolar ribonucleoprotein protein IMP4 isoform e
NM_001320310.2 NP_001307239.1 U3 small nucleolar ribonucleoprotein protein IMP4 isoform e
NM_001320311.2 NP_001307240.1 U3 small nucleolar ribonucleoprotein protein IMP4 isoform f
NM_001371725.1 NP_001358654.1 U3 small nucleolar ribonucleoprotein protein IMP4 isoform g
NM_001371726.1 NP_001358655.1 U3 small nucleolar ribonucleoprotein protein IMP4 isoform h
NM_001371728.1 NP_001358657.1 U3 small nucleolar ribonucleoprotein protein IMP4 isoform i
NM_001371730.1 NP_001358659.1 U3 small nucleolar ribonucleoprotein protein IMP4 isoform j
NM_001371731.1 NP_001358660.1 U3 small nucleolar ribonucleoprotein protein IMP4 isoform e
NM_001371732.1 NP_001358661.1 U3 small nucleolar ribonucleoprotein protein IMP4 isoform e
NM_001371733.1 NP_001358662.1 U3 small nucleolar ribonucleoprotein protein IMP4 isoform e
NM_001371734.1 NP_001358663.1 U3 small nucleolar ribonucleoprotein protein IMP4 isoform e
NM_033416.3 NP_219484.1 U3 small nucleolar ribonucleoprotein protein IMP4 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12655004 GOA
Biological Process GO Annotation Evidence References Source
involved in ribosomal small subunit biogenesis IDA
IDA: Inferred from direct assay
34516797 GOA
Cellular Component GO Annotation Evidence References Source
part of Mpp10 complex IDA
IDA: Inferred from direct assay
12655004 GOA
part of Mpp10 complex IPI
IPI: Inferred from physical interaction
12655004 GOA
located in nucleolus IDA
IDA: Inferred from direct assay
12655004 GOA
part of preribosome IDA
IDA: Inferred from direct assay
12655004 GOA
part of small-subunit processome IDA
IDA: Inferred from direct assay
34516797 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IMP4 Protein Structure

Brix

Brix: Brix domain (87 - 258)

  • 0
  • 100
  • 200
  • 291 a.a.
Protein Preferred Names Protein Names

U3 small nucleolar ribonucleoprotein protein IMP4

  • IMP4 homolog, U3 small nucleolar ribonucleoprotein

IMP4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
IMP4 Q96G21 ZBTB7B Homo sapiens O15156-2
Y2H Array
32296183
Intra
IMP4 Q96G21 ZBTB7B Homo sapiens O15156-2
Y2H Prey Pooling
32296183
Intra
IMP4 Q96G21 MPHOSPH10 Homo sapiens O00566
Pull Down
12655004
Intra
IMP4 Q96G21 ZBTB7B Homo sapiens O15156
Validated Y2H
25416956
Intra
IMP4 Q96G21 ZBTB7B Homo sapiens O15156
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-12826 IMB-XH1 Inhibitor 98.0% Unkown
HY-RS06794 IMP4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06868 IPO4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13705 SPPL2B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20755 Imp4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27267 Imp4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus IMP4 MGD MGI:106572
Felis catus IMP4 VGNC VGNC:62917
Bos taurus IMP4 VGNC VGNC:30183
Rattus norvegicus IMP4 RGD RGD:1308463
Macaca mulatta IMP4 VGNC VGNC:73689
Others IMP4 NCBI