Rnf111 - ring finger 111 Gene

Also Known as ARK; Arkadia

Species: Mus musculus

Gene Type: protein coding

Gene ID: 93836

Summary

Enables ubiquitin protein Ligase activity. Involved in positive regulation of transcription, DNA-templated. Acts upstream of or within several processes, including cellular protein metabolic process; positive regulation of protein ubiquitination; and positive regulation of transforming growth factor beta receptor signaling pathway. Located in cytoplasm and nucleus. Part of protein-containing complex. Is expressed in several structures, including heart; nervous system; testis; and urinary system. Orthologous to human RNF111 (ring finger protein 111). [provided by Alliance of Genome Resources, Apr 2022]

Rnf111 Products (3)

mRNA	Protein	Name
NM_001357494.1	NP_001344423.1	E3 ubiquitin-protein ligase Arkadia isoform 2
NM_001374753.1	NP_001361682.1	E3 ubiquitin-protein ligase Arkadia isoform 3
NM_033604.3	NP_291082.1	E3 ubiquitin-protein ligase Arkadia isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16601693	MGI
enables ubiquitin protein ligase activity	IMP IMP: Inferred from mutant phenotype	16601693	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within pattern specification process	IMP IMP: Inferred from mutant phenotype	11298452	MGI
acts upstream of or within positive regulation of protein ubiquitination	IDA IDA: Inferred from direct assay	16601693	MGI
acts upstream of or within positive regulation of protein ubiquitination	IMP IMP: Inferred from mutant phenotype	16601693	MGI
acts upstream of or within positive regulation of transforming growth factor beta receptor signaling pathway	IDA IDA: Inferred from direct assay	16601693	MGI
acts upstream of or within positive regulation of transforming growth factor beta receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	16601693	MGI
involved in positive regulation of transforming growth factor beta receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	16601693	MGI
acts upstream of or within protein polyubiquitination	IDA IDA: Inferred from direct assay	16601693	MGI
acts upstream of or within protein polyubiquitination	IGI IGI: Inferred from genetic interaction	16601693	MGI
acts upstream of or within protein polyubiquitination	IMP IMP: Inferred from mutant phenotype	16601693	MGI
involved in protein polyubiquitination	IMP IMP: Inferred from mutant phenotype	16601693	MGI
acts upstream of or within ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	16601693	MGI
acts upstream of or within ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	16601693	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	16601693	MGI
located in nucleus	IDA IDA: Inferred from direct assay	11555636	MGI
part of protein-containing complex	IDA IDA: Inferred from direct assay	16601693	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
E3 ubiquitin-protein ligase Arkadia	RING finger protein 111 RING-type E3 ubiquitin transferase Arkadia

Rnf111 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Rnf111	Q99ML9	Axin1	Mus musculus	O35625	Anti Tag CoIP	16601693
Intra	Rnf111	Q99ML9	Axin1	Mus musculus	O35625	Pull Down	16601693
Cross	Rnf111	Q99ML9	SMAD7	Homo sapiens	O15105	Anti Tag CoIP	16601693
Cross	Rnf111	Q99ML9	AXIN1	Homo sapiens	O15169	Imaging	16601693
Cross	Rnf111	Q99ML9	AXIN1	Homo sapiens	O15169	Anti Tag CoIP	16601693

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12036	RNF111 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rnf111	NCBI	NCBI:54778