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BAG2 - BAG cochaperone 2 Gene

Also Known as BAG-2; dJ417I1.2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9532

About BAG2

Cytogenetic location: 6p12.1 Genomic coordinates (GRCh38): 6:57,172,326-57,189,833 (from NCBI)

This gene has 1 transcript (splice variant) and 201 orthologues. Broad expression in endometrium (RPKM 20.1), urinary bladder (RPKM 13.7) and 21 other tissues.

Summary

BAG proteins compete with Hip for binding to the Hsc70/HSP70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 Amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008]

BAG2 Products (1)

mRNA	Protein	Name
NM_004282.4	NP_004273.1	BAG family molecular chaperone regulator 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables adenyl-nucleotide exchange factor activity	IDA IDA: Inferred from direct assay	24318877	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	22365833	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16207813	GOA
enables protein-folding chaperone binding	IPI IPI: Inferred from physical interaction	16207813	GOA
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	16207813	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in negative regulation of protein binding	IDA IDA: Inferred from direct assay	16207813	GOA
involved in negative regulation of protein ubiquitination	IDA IDA: Inferred from direct assay	24383081	GOA
involved in negative regulation of ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	16207813	GOA
involved in positive regulation of protein processing	IMP IMP: Inferred from mutant phenotype	16207813	GOA
acts upstream of or within protein metabolic process	IDA IDA: Inferred from direct assay	9873015	GOA
involved in protein stabilization	IDA IDA: Inferred from direct assay	16207813	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
part of protein folding chaperone complex	IPI IPI: Inferred from physical interaction	16207813	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BAG2 Protein Structure

BAG

0
100
200
211 a.a.

Protein Preferred Names	Protein Names
BAG family molecular chaperone regulator 2	BCL2 associated athanogene 2

BAG2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	BAG2	O95816	MLF2	Homo sapiens	Q15773	Anti Tag CoIP	25036637
Intra	BAG2	O95816	MLF2	Homo sapiens	Q15773	Anti Tag CoIP	33961781
Intra	BAG2	O95816	MLF2	Homo sapiens	Q15773	Lumier	25036637
Intra	BAG2	O95816	DISC1	Homo sapiens	Q9NRI5-2	Y2H Array	32296183
Intra	BAG2	O95816	DISC1	Homo sapiens	Q9NRI5-2	Validated Y2H	32296183
Intra	BAG2	O95816	DISC1	Homo sapiens	Q9NRI5-2	Y2H Prey Pooling	32296183
Intra	BAG2	O95816	MAPK7	Homo sapiens	Q13164	Anti Bait CoIP	31980649
Intra	BAG2	O95816	HSF2	Homo sapiens	Q03933	Anti Tag CoIP	33961781
Intra	BAG2	O95816	SGTA	Homo sapiens	O43765	Lumier	25036637
Intra	BAG2	O95816	HSPA8	Homo sapiens	P11142	Anti Tag CoIP	33961781
Intra	BAG2	O95816	HSPA8	Homo sapiens	P11142	TAP	18457437
Intra	BAG2	O95816	HSPA8	Homo sapiens	P11142	Crosslink	30021884
Intra	BAG2	O95816	ATXN1	Homo sapiens	P54253	Y2H Array	32814053
Intra	BAG2	O95816	BAG2	Homo sapiens	O95816	Lumier	25036637
Intra	BAG2	O95816	BAG2	Homo sapiens	O95816	Y2H Array	25416956
Intra	BAG2	O95816	DNAJC7	Homo sapiens	Q99615	Anti Tag CoIP	33961781
Intra	BAG2	O95816	BAG2	Homo sapiens	O95816	Y2H	22365833
Intra	BAG2	O95816	STUB1	Homo sapiens	Q9UNE7	Anti Tag CoIP	33961781
Intra	BAG2	O95816	STUB1	Homo sapiens	Q9UNE7	Anti Tag CoIP	25036637
Intra	BAG2	O95816	STUB1	Homo sapiens	Q9UNE7	Lumier	25036637
Intra	BAG2	O95816	DAPK1	Homo sapiens	P53355	Protein Array	29513927
Intra	BAG2	O95816	LRRK2	Homo sapiens	Q5S007	Protein Array	29513927
Intra	BAG2	O95816	ATXN1	Homo sapiens	P54253	Validated Y2H	32814053
Intra	BAG2	O95816	ATXN1	Homo sapiens	P54253	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant BAG2 Proteins

Art. -Nr.	Produktname	Accession	Reinheit
HY-P7647	BAG-2 Protein, Human (His)	O95816 (M1-N211)	≥ 90%, as determined by reducing SDS-PAGE.

BAG2 Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P81653	BAG2 Antibody (YA1398)	WB, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Chronic Frontal Sinusitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS01343	BAG2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18911	Bag2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25402	Bag2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	BAG2	MGD	MGI:1891254
Felis catus	BAG2	VGNC	VGNC:102385
Canis familiaris	BAG2	VGNC	VGNC:38364
Bos taurus	BAG2	VGNC	VGNC:26406
Rattus norvegicus	BAG2	RGD	RGD:1585173
Others	BAG2	NCBI