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Wwtr1 - WW domain containing transcription regulator 1 Gene

Also Known as Taz; 2310058J06Rik; 2610021I22Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 97064

Summary

This gene encodes a binding protein of the 14-3-3 family of proteins that regulate cell cycle progression, differentiation and Apoptosis. The encoded protein is a transcriptional co-activator that binds to the PPXY motif present on transcription factors. The gene product contains a WW domain and, in the C-terminus, a conserved PDZ-binding motif. This gene is distinct from the gene encoding tafazzin. Both genes share the gene symbol Taz. Multiple transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2010]

Wwtr1 Products (2)

mRNA	Protein	Name
NM_001168281.1	NP_001161753.1	WW domain-containing transcription regulator protein 1 isoform 1
NM_133784.3	NP_598545.2	WW domain-containing transcription regulator protein 1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11118213	MGI
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	16332960	MGI
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	16332960	MGI
enables transcription corepressor activity	IGI IGI: Inferred from genetic interaction	16099986	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	17636028	MGI
acts upstream of or within cilium assembly	IMP IMP: Inferred from mutant phenotype	17251353	MGI
acts upstream of or within glomerulus development	IMP IMP: Inferred from mutant phenotype	18172001	MGI
involved in heart process	IMP IMP: Inferred from mutant phenotype	23918388	MGI
acts upstream of or within kidney morphogenesis	IMP IMP: Inferred from mutant phenotype	17636028	MGI
acts upstream of or within mesenchymal cell differentiation	IMP IMP: Inferred from mutant phenotype	17636028	MGI
acts upstream of or within multicellular organism growth	IMP IMP: Inferred from mutant phenotype	17636028	MGI
acts upstream of or within negative regulation of fat cell differentiation	IGI IGI: Inferred from genetic interaction	16099986	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	16099986	MGI
acts upstream of or within osteoblast differentiation	IGI IGI: Inferred from genetic interaction	16099986	MGI
acts upstream of or within osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	16099986	MGI
involved in positive regulation of protein localization to nucleus	IMP IMP: Inferred from mutant phenotype	21145499	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	14970209	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	14970209	MGI
acts upstream of or within protein ubiquitination	IDA IDA: Inferred from direct assay	17636028	MGI
involved in protein ubiquitination	IMP IMP: Inferred from mutant phenotype	21474562	MGI
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	14970209	MGI
acts upstream of or within regulation of canonical Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	23974041	MGI
acts upstream of or within regulation of metanephric nephron tubule epithelial cell differentiation	IGI IGI: Inferred from genetic interaction	23974041	MGI
involved in tissue homeostasis	IMP IMP: Inferred from mutant phenotype	23918388	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11118213	MGI
located in nucleus	IDA IDA: Inferred from direct assay	11118213	MGI
part of transcription regulator complex	IDA IDA: Inferred from direct assay	14970209	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
WW domain-containing transcription regulator protein 1	transcriptional coactivator with PDZ-binding motif

Wwtr1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	Wwtr1	Q9EPK5	CCAR1	Homo sapiens	Q8IX12	Anti Tag CoIP	20594350
Cross	Wwtr1	Q9EPK5	CCAR1	Homo sapiens	Q8IX12	IF	20594350
Cross	Wwtr1	Q9EPK5	CTNNB1	Homo sapiens	P35222	Anti Tag CoIP	23245942
Cross	Wwtr1	Q9EPK5	TJP1	Homo sapiens	Q07157	Pull Down	20850437
Cross	Wwtr1	Q9EPK5	Nkx2-1	Rattus norvegicus	P23441	Pull Down	14970209
Cross	Wwtr1	Q9EPK5	TJP2	Canis familiaris	Q95168	Pull Down	20850437
Cross	Wwtr1	Q9EPK5	TJP2	Canis familiaris	Q95168	IF	20850437

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16236	Wwtr1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS15862	WWTR1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16450	Wwtr1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Wwtr1	NCBI	NCBI:25937