SRGAP3 - SLIT-ROBO Rho GTPase activating protein 3 Gene

Also Known as WRP; MEGAP; SRGAP2; ARHGAP14

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9901

About SRGAP3

Cytogenetic location: 3p25.3 Genomic coordinates (GRCh38): 3:8,980,591-9,363,027 (from NCBI)

This gene has 12 transcripts (splice variants), 262 orthologues, 5 paralogues and is associated with 90 phenotypes. Broad expression in brain (RPKM 6.5), urinary bladder (RPKM 1.5) and 16 other tissues.

Summary

Predicted to enable GTPase activator activity. Predicted to be involved in negative regulation of cell migration. Predicted to be located in cytosol. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

SRGAP3 Products (2)

mRNA	Protein	Name
NM_001033117.3	NP_001028289.1	SLIT-ROBO Rho GTPase-activating protein 3 isoform b
NM_014850.4	NP_055665.1	SLIT-ROBO Rho GTPase-activating protein 3 isoform a

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17500595	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in postsynapse	IDA IDA: Inferred from direct assay	30123108	GOA
is active in postsynapse	IMP IMP: Inferred from mutant phenotype	30123108	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SRGAP3 Protein Structure

FCH

RhoGAP

SH3_1

0
200
400
600
800
1000
1099 a.a.

Protein Preferred Names	Protein Names
SLIT-ROBO Rho GTPase-activating protein 3	SLIT-ROBO Rho GTPase activating protein 2

SRGAP3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SRGAP3	O43295	GRB2	Homo sapiens	P62993	Anti Tag CoIP	25819436
Intra	SRGAP3	O43295	GRB2	Homo sapiens	P62993	ITC	25819436
Intra	SRGAP3	O43295	HTT	Homo sapiens	P42858	Y2H	17500595
Cross	SRGAP3	O43295	Sh3gl2	Rattus norvegicus	O35179	ITC	25819436
Cross	SRGAP3	O43295	Sh3gl2	Rattus norvegicus	O35179	Pull Down	25819436
Cross	SRGAP3	O43295	Sh3gl1	Rattus norvegicus	O35964	Pull Down	25819436
Cross	SRGAP3	O43295	Sh3gl1	Rattus norvegicus	O35964	ITC	25819436
Cross	SRGAP3	O43295	Amph	Rattus norvegicus	O08838	Pull Down	25819436
Cross	SRGAP3	O43295	Amph	Rattus norvegicus	O08838	ITC	25819436
Cross	SRGAP3	O43295	Amph	Rattus norvegicus	O08838	Anti Tag CoIP	25819436

Cross: Cross-species interaction Intra: Intraspecies interaction

SRGAP3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P89582	WRP Antibody (YA8926)	WB, ICC/IF, IF-Tissue, IHC-P, IP, ELISA	human, mouse, rat

Related Diseases

Diseases	Alias
Pilomyxoid Astrocytoma
Chromosome 3pter-P25 Deletion Syndrome	3p- Syndrome 3p Deletion Syndrome Distal Monosomy 3p Chromosome 3, Monosomy 3p 3p Partial Monosomy Syndrome Chromosome 3, Deletion 3p Chromosome 3p Deletion Syndrome Del Syndrome Deletion 3p Monosomy 3p Partial Monosomy 3p Distal 3p Deletion Monosomy 3pter Telomeric Monosomy 3p Chromosome Deletion Syndrome 3pter-P25
Lissencephaly 5	LIS5 Cobblestone Lissencephaly Without Muscular Or Ocular Involvement Cobblestone Lissencephaly Without Muscular Or Eye Involvement Lissencephaly Type 2 Without Muscular Or Eye Involvement Lissencephaly Type 2 Without Muscular Or Ocular Involvement Lissencephaly, Type 5
Avoidant Personality Disorder	Anxious Personality Disorder Personality Disorders
Retinitis Pigmentosa 23	RP23 Retinitis Pigmentosa-23 Retinitis Pigmentosa, Type 23 Rp23 Gene
Fibrillary Astrocytoma	Fibrillary Astrocytic Tumors Diffuse Astrocytoma Gemistocytic Astrocytoma Protoplasmic Astrocytoma
Childhood Astrocytic Tumor	Juvenile Astrocytoma Pediatric Astrocytoma
Pilocytic Astrocytoma	Juvenile Pilocytic Astrocytoma Grade I Astrocytic Tumor Piloid Astrocytoma
Early Infantile Epileptic Encephalopathy	Early Infantile Epileptic Encephalopathy With Burst-Suppression Early Infantile Epileptic Encephalopathy With Suppression Bursts Eiee Early Infantile Epileptic Encephalopathy With Suppression-Bursts Ohtahara Syndrome Encephalopathy, Epileptic, Early Infantile

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13763	SRGAP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS13765	SRGAP3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SRGAP3	VGNC	VGNC:46802
Macaca mulatta	SRGAP3	VGNC	VGNC:77968
Bos taurus	SRGAP3	VGNC	VGNC:35279
Rattus norvegicus	SRGAP3	RGD	RGD:1563152
Felis catus	SRGAP3	VGNC	VGNC:65680
Mus musculus	SRGAP3	MGD	MGI:2152938
Others	SRGAP3	NCBI