Germacrone 4,5-epoxide

Cat. No.: HY-N8402: Data Sheet Handling Instructions
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Germacrone 4,5-epoxide is a sesquiterpene that can be isolated from Curcuma cf. viridiflora. Germacrone 4,5-epoxide has excellent anti-leukemic activities.

For research use only. We do not sell to patients.

Germacrone 4,5-epoxide Chemical Structure

CAS No. : 92691-35-5

Size	Stock	Quantity
1 mg	Get quote 2 - 3 weeks 1 - 2 Weeks 3 - 4 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
5 mg	Get quote 2 - 3 weeks 1 - 2 Weeks 3 - 4 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
10 mg	Get quote
50 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Germacrone 4,5-epoxide is a sesquiterpene that can be isolated from Curcuma cf. viridiflora. Germacrone 4,5-epoxide has excellent anti-leukemic activities^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HT-29	IC₅₀	39.6 μg/mL Compound: 3	Cytotoxicity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 29274817]
HUVEC	IC₅₀	48.4 μg/mL Compound: 3	Cytotoxicity against human HUVEC cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human HUVEC cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 29274817]
KG-1a	IC₅₀	> 100 μg/mL Compound: 3	Cytotoxicity against human KG1a cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human KG1a cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 29274817]
MCF7	IC₅₀	37.2 μg/mL Compound: 3	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 29274817]
MOLT-4	IC₅₀	53 μg/mL Compound: 3	Cytotoxicity against human MOLT4 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human MOLT4 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 29274817]
MOLT-4	IC₅₀	> 100 μg/mL Compound: 3	Cytotoxicity against human MOLT4 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human MOLT4 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 29274817]
PC-3	IC₅₀	43.9 μg/mL Compound: 3	Cytotoxicity against human PC3 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human PC3 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 29274817]

Molecular Weight

234.33

Formula

C₁₅H₂₂O₂

CAS No.

92691-35-5

SMILES

C[C@]1(CC/C=C2C)[C@@](C/C(C(C\2)=O)=C(C)/C)([H])O1

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Anuchapreeda S, et al. Cytotoxicity and inhibition of leukemic cell proliferation by sesquiterpenes from rhizomes of Mah-Lueang (Curcuma cf. viridiflora Roxb.). Bioorg Med Chem Lett. 2018 Feb 1;28(3):410-414. [Content Brief]