1. Cell Cycle/DNA Damage Cytoskeleton
  2. Microtubule/Tubulin
  3. Glochidiol

Glochidiol is an orally active tubulin polymerization inhibitor with an IC50 of 2.76 μM. Glochidiol shows anti-cancer activity.

For research use only. We do not sell to patients.

Glochidiol Chemical Structure

Glochidiol Chemical Structure

CAS No. : 6610-56-6

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Description

Glochidiol is an orally active tubulin polymerization inhibitor with an IC50 of 2.76 μM. Glochidiol shows anti-cancer activity[1].

IC50 & Target

IC50: 2.76 μΜ (tubulin polymerization)[1]

In Vitro

Glochidiol (1-8 μM; 48 h) shows potent antiproliferative activity against lung cancer cell lines in a concentration-dependent manner[1].
Glochidiol interacts with tubulin by targeting the colchicine binding site[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: NCI-H2087, HOP-62, NCI-H520, HCC-44, HARA, EPLC-272H, NCI-H3122, COR-L105 and Calu-6
Concentration: 1, 2, 4 and 8 μM
Incubation Time: 48 h
Result: Showed potent antiproliferative activity against lung cancer cell lines NCI-H2087, HOP-62, NCI-H520, HCC-44, HARA, EPLC-272H, NCI-H3122, COR-L105 and Calu-6 with IC50 values of 4.12 µM, 2.01 µM, 7.53 µM, 1.62 µM, 4.79 µM, 7.69 µM, 2.36 µM, 6.07 µM and 2.10 µM, respectively.
In Vivo

Glochidiol (60 mg/kg/day; i.g.; 21 days) effectively inhibits lung cancer HCC-44 xenograft tumor growth in nude mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c nude mice bearing HCC-44 xenografts[1]
Dosage: 60 mg/kg/day
Administration: Intragastric administration for a period of 21 days
Result: Decreased average tumor weight and relative tumor volume with no obvious cytotoxic effect on the major organs, including heart, liver, and kidney.
Molecular Weight

442.72

Formula

C30H50O2

CAS No.
SMILES

C[C@]12[C@@](CC[C@@]3([H])[C@]2(CC[C@]4(C)[C@]3([H])[C@@H](CC4)C(C)=C)C)([H])[C@@]5([C@@](C(C)([C@H](O)C[C@H]5O)C)([H])CC1)C

Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Glochidiol Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Glochidiol
Cat. No.:
HY-N3950
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