Glucoraphasatin potassium
Glucoraphasatin potassium is potassium salt of Glucoraphasatin (HY-N11822). Glucoraphasatin is an atypical and orally active glucosinolate found in cruciferous vegetables, including Raphanus sativus. Glucoraphasatin exhibits anti-inflammation and anti-oxidant activity. Glucoraphasatin can affect phase I metabolic enzymes activity. Glucoraphasatin can be converted by the plant enzyme myrosinase into isothiocyanates and shows cytotoxic to cancer cells. Glucoraphasatin can be used for the researches of cancer and inflammation, such as colon cancer.
For research use only. We do not sell to patients.
- CAS No.: 245550-64-5
- Formula: C12H20KNO9S3
- Molecular Weight:457.58
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Glucoraphasatin possesses reducing capacity against, both H2O2 and the 2,2’-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) radical cation (ABTS+)[1].
Glucoraphasatin (50 μM, 3-6 days) inhibits proliferation companied with myrosinase in LoVo, HCT-116, and HT-29 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:SD rats[1]
-
Dosage:120 mg/kg
-
Administration:Orally administration, daily for 1 or 4 days
-
Result:Resulted in a 2.4-fold increase in CYP3A1/2-linked monooxygenase (aminopyrine N-demethylase) and a 1.6-fold increase in CYP1A2-supported monooxygenase (methoxyresorufin O-demethylase).
Increased CYP1A1-linked monooxygenase (ethoxyresorufin O-deethylase) and the CYP2B1/2-supported oxidase (pentoxyresorufin O-dealkylase) by 1.5-fold.
Reduced CYP2E1-linked monooxygenase (p-nitrophenolhydroxylase) activity.
Chemical Information
-
CAS No. 245550-64-5
-
Molecular Weight 457.58
-
Formula C12H20KNO9S3
-
SMILES
CS/C=C/CC/C(S[C@@H]1O[C@@H]([C@H]([C@@H]([C@H]1O)O)O)CO)=N/OS(=O)(O[K])=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Montaut S, et al. Glucoraphasatin: chemistry, occurrence, and biological properties. Phytochemistry. 2010 Jan;71(1):6-12. [Content Brief]
[2]. Papi A, et al. Cytotoxic and antioxidant activity of 4-methylthio-3-butenyl isothiocyanate from Raphanus sativus L. (Kaiware Daikon) sprouts. J Agric Food Chem. 2008 Feb 13;56(3):875-83. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Glucoraphasatin potassium Related Classifications
HY-N11822A Related Classifications
Powered by Bioz