Gly-Mal-GGFG-Deruxtecan 2-hydroxypropanamide

Name: Gly-Mal-GGFG-Deruxtecan 2-hydroxypropanamide
Brand: MedChemExpress
SKU: HY-153892
Rating: 4.5 (0 reviews)

製品番号: HY-153892 純度: 99.01%: Data Sheet SDS COA 取扱説明書
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Gly-Mal-GGFG-Deruxtecan 2-hydroxypropanamide is the drug-linker conjugate for ADC, containing ADC linker Gly-Mal-GGFG and ADC cytotoxin Deruxtecan 2-hydroxypropanamide.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

Gly-Mal-GGFG-Deruxtecan 2-hydroxypropanamide 構造式

CAS 番号 : 2750623-07-3

容量	価格（税別）	在庫状況	数量
1 mg	$1150	在庫あり	Estimated Time of Arrival: December 31
5 mg	$2900	在庫あり	Estimated Time of Arrival: December 31
10 mg	$4650	在庫あり	Estimated Time of Arrival: December 31
50 mg		お問い合わせ
100 mg		お問い合わせ

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* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 0 publication(s) in Google Scholar

Drug-Linker Conjugates for ADC アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

Auristatin Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents Dual payloads

Topoisomerase アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

Topoisomerase Topo I Topo II DNA gyrase

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

Gly-Mal-GGFG-Deruxtecan 2-hydroxypropanamide is the drug-linker conjugate for ADC, containing ADC linker Gly-Mal-GGFG and ADC cytotoxin Deruxtecan 2-hydroxypropanamide^[1].

体外実験

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1079.05

分子式

C₅₂H₅₅FN₁₀O₁₅

CAS 番号

2750623-07-3

Appearance

Solid

Color

Light yellow to yellow

SMILES

OC(CNC[C@H](N1C(C=CC1=O)=O)C(NCC(NCC(N[C@@H](CC2=CC=CC=C2)C(NCC(NCO[C@@H](C)C(N[C@@H]3C4=C5C(C(N6C5)=CC([C@](O)(C(OC7)=O)CC)=C7C6=O)=NC8=CC(F)=C(C)C(CC3)=C84)=O)=O)=O)=O)=O)=O)=O

輸送条件

Shipping with dry ice.

保管条件

-80°C, protect from light

溶剤 & 溶解度

体外:

DMSO : 25 mg/mL (23.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.9267 mL	4.6337 mL	9.2674 mL
5 mM	0.1853 mL	0.9267 mL	1.8535 mL
10 mM	0.0927 mL	0.4634 mL	0.9267 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (protect from light). When stored at -80°C, please use it within 6 months.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 99.79%

Select Batch:

データシート (276 KB) SDS (251 KB)

COA (259 KB) HNMR (339 KB) RP-HPLC (258 KB) LCMS (97 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Zhu Yi, et al. Camptothecin derivative and ligand-drug conjugate thereof. WO2022078260A1. 2021.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.9267 mL	4.6337 mL	9.2674 mL	23.1685 mL
	5 mM	0.1853 mL	0.9267 mL	1.8535 mL	4.6337 mL
	10 mM	0.0927 mL	0.4634 mL	0.9267 mL	2.3169 mL
	15 mM	0.0618 mL	0.3089 mL	0.6178 mL	1.5446 mL
	20 mM	0.0463 mL	0.2317 mL	0.4634 mL	1.1584 mL