Gochnatiolide A
Gochnatiolide A is a dimeric sesquiterpene that can be found in Ainsliaea henryi. Gochnatiolide A exhibits antiproliferative activity against the kidney, melanoma, ovarian-resistant and glioma cell lines.
For research use only. We do not sell to patients.
- CAS No.: 87606-12-0
- Formula: C30H30O7
- Molecular Weight:502.56
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| C6 | IC50 |
1.2 μM
Compound: 4
|
Cytotoxicity against rat C6 cells assessed as reduction in cell viability incubated for 72 hrs by Celltiter-Glo assay
Cytotoxicity against rat C6 cells assessed as reduction in cell viability incubated for 72 hrs by Celltiter-Glo assay
|
[PMID: 34496568] |
| HCCLM3 | IC50 |
>10 μM
Compound: 4
|
Cytotoxicity against human HCCLM3 cells assessed as reduction in cell viability incubated for 72 hrs by Celltiter-Glo assay
Cytotoxicity against human HCCLM3 cells assessed as reduction in cell viability incubated for 72 hrs by Celltiter-Glo assay
|
[PMID: 34496568] |
| HeLa | IC50 |
2.8 μM
Compound: 4
|
Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 72 hrs by Celltiter-Glo assay
Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 72 hrs by Celltiter-Glo assay
|
[PMID: 34496568] |
| Huh-7 | IC50 |
2.5 μM
Compound: 4
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Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability incubated for 72 hrs by Celltiter-Glo assay
Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability incubated for 72 hrs by Celltiter-Glo assay
|
[PMID: 34496568] |
| PANC-1 | IC50 |
2.2 μM
Compound: 4
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Cytotoxicity against human PANC-1 cells assessed as reduction in cell viability incubated for 72 hrs by Celltiter-Glo assay
Cytotoxicity against human PANC-1 cells assessed as reduction in cell viability incubated for 72 hrs by Celltiter-Glo assay
|
[PMID: 34496568] |
Gochnatiolide A (0.25-250 μg/mL; 48 h) inhibits cell growth, with values of TGI (total growth inhibition) of 0.42, 0.49, 0.70, 1.09, 1.69, 4.66, 5.42, 6.63, 54.73, 13.13, and 114.87 μg/mL for 786.0, UACC-62, NCI-ADR/RES, U251, MCF-7, NCI-H460, HT-29, PC-3, OVCAR-3, VERO, and K562 cells, respectively[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 87606-12-0
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Molecular Weight 502.56
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Formula C30H30O7
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SMILES
O=C1[C@]2([C@]3([H])[C@]4([H])[C@](CCC([C@]3([H])C1)=C)([H])C(C(O4)=O)=C)C5=C6[C@]([C@]7([H])[C@@](C(C(O7)=O)=C)([H])CC[C@@]6(CC2)O)([H])C(C5=O)=C
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Xiong HP, et, al. A dimeric sesquiterpene, gochnatiolide A. Acta Crystallogr Sect E Struct Rep Online. 2009 Oct 23;65(Pt 11):o2847. [Content Brief]
[2]. Strapasson RLB, et, al. Bioactivity-guided isolation of cytotoxic sesquiterpene lactones of Gochnatia polymorpha ssp. Floccose. Phytother Res. 2012 Jul;26(7):1053-6. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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