country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-190675

Copy Link Print Information

GPR52 agonist-5

GPR52 agonist-5 is a GPR52 agonist. GPR52 agonist-5 activates GPR52-mediated signaling and attenuates hyperactivity in a mouse model of hyperactive behavior. GPR52 agonist-5 can be used in research on nervous system-related diseases.

For research use only. We do not sell to patients.

CAS No.: 1207965-14-7
Formula: C₂₅H₂₀F₃NO₂S
Molecular Weight:455.49

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

GPR52 agonist-5 Chemical Structure

CAS No.: 1207965-14-7

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
HTLA	EC50	37.7 nM	EC50 for GPR52 activation by compound 7d in GPR52 HTLA cells assessed by TANGO β-arrestin reporter assay in reference assay series 1. EC50 for GPR52 activation by compound 7d in GPR52 HTLA cells assessed by TANGO β-arrestin reporter assay in reference assay series 1.	42785394
HTLA	EC50	31.9 nM	EC50 for GPR52 activation by compound 7d in GPR52 HTLA cells assessed by TANGO β-arrestin reporter assay in reference assay series 2. EC50 for GPR52 activation by compound 7d in GPR52 HTLA cells assessed by TANGO β-arrestin reporter assay in reference assay series 2.	42785394

In Vitro

GPR52 agonist-5 (compound 7d) activates GPR52 in GPR52 TANGO/HTLA cells, with EC₅₀ values of 37.7 nM and 31.9 nM in two reference assay series, respectively, and a relative maximum response of 100%^[1].
GPR52 agonist-5 can serve as a photocage-modified parent core molecule, and photolabile group modification yields the photoactivatable derivatives DMNB‑7d and CNV‑7d^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Glutamate Release or Receptors

GPR52 agonist-5 (compound 7d) (10 mg/kg; i.p.; single administration) reduces hyperlocomotion in MK-801 (HY-15084B)-treated mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

How to Choose the Right Model Animal

Chemical Information

CAS No. 1207965-14-7
Molecular Weight 455.49
Formula C₂₅H₂₀F₃NO₂S
SMILES

FC(F)(C1=CC(CC2=CC3=C(C(C4=CC(C(NCCO)=O)=CC=C4)=CC=C3)S2)=CC=C1)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Ren W, et al. Photocaging of a GPR52 agonist enables light-dependent receptor activation in cells. Bioorganic & medicinal chemistry letters. 2027 Jan;142:130783.

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote