GPX4-IN-15
Based on 1 Customer Validation
GPX4-IN-15 (Compound C1) is an inhibitor for GPX4, that inhibits 19.8% GPX4 at 1 μM. GPX4-IN-15 inhibits the proliferation of cancer cell MDA-MB-468, BT-549 and MDA-MB-231 with IC50 of 0.86, 0.96 and 0.48 μM.
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- Purity: 98.79%
- CAS No.: 3032966-42-7
- 화학식: C17H15Cl2NO4
- 분자량:368.21
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보관:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
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Biological Activity
|
GPX4 |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| BT-549 | IC50 |
0.68 μM
Compound: C1
|
Antiproliferative activity against human BT-549 cells assessed as inhibition of cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human BT-549 cells assessed as inhibition of cell viability incubated for 72 hrs by MTT assay
|
[PMID: 37452764] |
| MDA-MB-231 | IC50 |
0.38 μM
Compound: C1
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Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell viability incubated for 72 hrs by MTT assay
|
[PMID: 37452764] |
| MDA-MB-231 | IC50 |
8.09 μM
Compound: C1
|
Induction of ferroptosis in human MDA-MB-231 cells assessed as cell viability incubated for 72 hrs in presence of ferroptosis inhibitor, ferrostatin-1 by MTT assay
Induction of ferroptosis in human MDA-MB-231 cells assessed as cell viability incubated for 72 hrs in presence of ferroptosis inhibitor, ferrostatin-1 by MTT assay
|
[PMID: 37452764] |
| MDA-MB-468 | IC50 |
0.28 μM
Compound: C1
|
Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell viability incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell viability incubated for 72 hrs by CCK-8 assay
|
[PMID: 37452764] |
Chemical Information
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CAS No. 3032966-42-7
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Appearance Solid
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분자량 368.21
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화학식 C17H15Cl2NO4
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Color White to light yellow
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SMILES
O=C(OC)C1=CC=C(N(C(CCl)=O)C2=CC=C(OC)C(Cl)=C2)C=C1
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
DMSO : 50 mg/mL (135.79 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7158 mL | 13.5792 mL | 27.1584 mL | 67.8960 mL |
| 5 mM | 0.5432 mL | 2.7158 mL | 5.4317 mL | 13.5792 mL | |
| 10 mM | 0.2716 mL | 1.3579 mL | 2.7158 mL | 6.7896 mL | |
| 15 mM | 0.1811 mL | 0.9053 mL | 1.8106 mL | 4.5264 mL | |
| 20 mM | 0.1358 mL | 0.6790 mL | 1.3579 mL | 3.3948 mL | |
| 25 mM | 0.1086 mL | 0.5432 mL | 1.0863 mL | 2.7158 mL | |
| 30 mM | 0.0905 mL | 0.4526 mL | 0.9053 mL | 2.2632 mL | |
| 40 mM | 0.0679 mL | 0.3395 mL | 0.6790 mL | 1.6974 mL | |
| 50 mM | 0.0543 mL | 0.2716 mL | 0.5432 mL | 1.3579 mL | |
| 60 mM | 0.0453 mL | 0.2263 mL | 0.4526 mL | 1.1316 mL | |
| 80 mM | 0.0339 mL | 0.1697 mL | 0.3395 mL | 0.8487 mL | |
| 100 mM | 0.0272 mL | 0.1358 mL | 0.2716 mL | 0.6790 mL |
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