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Cat. No.: HY-159990

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GPX4-IN-15

Name: GPX4-IN-15
Brand: MedChemExpress
SKU: HY-159990
Price: 95.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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GPX4-IN-15 (Compound C1) is an inhibitor for GPX4, that inhibits 19.8% GPX4 at 1 μM. GPX4-IN-15 inhibits the proliferation of cancer cell MDA-MB-468, BT-549 and MDA-MB-231 with IC₅₀ of 0.86, 0.96 and 0.48 μM.

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Pureté : 98.79%
CAS No.: 3032966-42-7
Formule: C₁₇H₁₅Cl₂NO₄
Masse moléculaire:368.21

Stockage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

GPX4-IN-15 Chemical Structure

CAS No.: 3032966-42-7

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Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Solvant et solubilité
- In Vitro
Pureté et documentation
Références
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target

GPX4

Voir tous les produits spécifiques à Isoform Glutathione Peroxidase :

GPX1
GPX4

Cellular Effect

Cell Line	Type	Value	Description	References
BT-549	IC₅₀	0.68 μM Compound: C1	Antiproliferative activity against human BT-549 cells assessed as inhibition of cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human BT-549 cells assessed as inhibition of cell viability incubated for 72 hrs by MTT assay	[PMID: 37452764]
MDA-MB-231	IC₅₀	0.38 μM Compound: C1	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell viability incubated for 72 hrs by MTT assay	[PMID: 37452764]
MDA-MB-231	IC₅₀	8.09 μM Compound: C1	Induction of ferroptosis in human MDA-MB-231 cells assessed as cell viability incubated for 72 hrs in presence of ferroptosis inhibitor, ferrostatin-1 by MTT assay Induction of ferroptosis in human MDA-MB-231 cells assessed as cell viability incubated for 72 hrs in presence of ferroptosis inhibitor, ferrostatin-1 by MTT assay	[PMID: 37452764]
MDA-MB-468	IC₅₀	0.28 μM Compound: C1	Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell viability incubated for 72 hrs by CCK-8 assay Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell viability incubated for 72 hrs by CCK-8 assay	[PMID: 37452764]

Chemical Information

CAS No. 3032966-42-7
Appearance Solid
Masse moléculaire 368.21
Formule C₁₇H₁₅Cl₂NO₄
Color White to light yellow
SMILES

O=C(OC)C1=CC=C(N(C(CCl)=O)C2=CC=C(OC)C(Cl)=C2)C=C1
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvant et solubilité

In Vitro:

DMSO : 50 mg/mL (135.79 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.7158 mL

13.5792 mL

27.1584 mL

5 mM

0.5432 mL

2.7158 mL

5.4317 mL

10 mM

0.2716 mL

1.3579 mL

2.7158 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (275 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Chen T, et al., Discovery of Novel Potent Covalent Glutathione Peroxidase 4 Inhibitors as Highly Selective Ferroptosis Inducers for the Treatment of Triple-Negative Breast Cancer. J Med Chem. 2023 Jul 27;66(14):10036-10059. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.7158 mL	13.5792 mL	27.1584 mL	67.8960 mL
	5 mM	0.5432 mL	2.7158 mL	5.4317 mL	13.5792 mL
	10 mM	0.2716 mL	1.3579 mL	2.7158 mL	6.7896 mL
	15 mM	0.1811 mL	0.9053 mL	1.8106 mL	4.5264 mL
	20 mM	0.1358 mL	0.6790 mL	1.3579 mL	3.3948 mL
	25 mM	0.1086 mL	0.5432 mL	1.0863 mL	2.7158 mL
	30 mM	0.0905 mL	0.4526 mL	0.9053 mL	2.2632 mL
	40 mM	0.0679 mL	0.3395 mL	0.6790 mL	1.6974 mL
	50 mM	0.0543 mL	0.2716 mL	0.5432 mL	1.3579 mL
	60 mM	0.0453 mL	0.2263 mL	0.4526 mL	1.1316 mL
	80 mM	0.0339 mL	0.1697 mL	0.3395 mL	0.8487 mL
	100 mM	0.0272 mL	0.1358 mL	0.2716 mL	0.6790 mL

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Minimum order quantity

100 mg

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Activité biologique
- Description
- IC₅₀ & Target
Chemical Information
Solvant et solubilité
- In Vitro
Pureté et documentation
Références

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GPX4-IN-15

Voir tous les produits spécifiques à Isoform Glutathione Peroxidase

Activité biologique

Description

IC50 & Target

Cellular Effect

Chemical Information

Solvant et solubilité

In Vitro:

In Vivo Dissolution Calculator

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

GPX4-IN-15 Related Classifications

HY-159990 Related Classifications

Bioz

Keywords

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