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Cat. No.: HY-111254R

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GQ-16 (Standard)

GQ-16 (Standard) is the analytical standard of GQ-16 (HY-111254). This product is intended for research and analytical applications. GQ-16 is an orally active PPARγ partial agonist with an IC₅₀ of 1.84 μM and a K_i of 160 nM against human PPARγ. GQ-16 inhibits Cdk5-mediated Ser-273 phosphorylation. GQ-16 improves insulin sensitivity and glucose tolerance in obese and diabetic mice. GQ-16 also exhibits certain cytotoxicity against tumor cells. GQ-16 can be used in research related to obesity, diabetes and cancer.

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CAS No.: 870554-67-9
Formule: C₁₉H₁₆BrNO₃S
Masse moléculaire:418.30

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

GQ-16 (Standard) Chemical Structure

CAS No.: 870554-67-9

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Product Information

Information

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 870554-67-9
Masse moléculaire 418.30
Formule C₁₉H₁₆BrNO₃S
SMILES

O=C(N(CC1=CC=C(C)C=C1)C/2=O)SC2=C/C3=CC(Br)=CC=C3OC
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Ferreira A P B, et al. Effect of PPAR Partial Agonist, GQ‐16, on Viability of Breast Cancer Cells in Culture. The FASEB Journal, 2017, 31: 876.5-876.5.

[2]. Milton FA, et al. PPARγ partial agonist GQ-16 strongly represses a subset of genes in 3T3-L1 adipocytes. Biochem Biophys Res Commun. 2015 Aug 28;464(3):718-23. [Content Brief]

[3]. Amato AA, et al. GQ-16, a novel peroxisome proliferator-activated receptor γ (PPARγ) ligand, promotes insulin sensitization without weight gain. J Biol Chem. 2012;287(33):28169-28179. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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