1. Apoptosis
  2. RIP kinase
  3. GSK3145095

GSK3145095 

Cat. No.: HY-111946
Handling Instructions

GSK3145095 is a RIP1 kinase inhibitor with an IC50 of 6.3 nM .

For research use only. We do not sell to patients.

GSK3145095 Chemical Structure

GSK3145095 Chemical Structure

CAS No. : 1622849-43-7

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Description

GSK3145095 is a RIP1 kinase inhibitor with an IC50 of 6.3 nM [1].

IC50 & Target

IC50: 6.3 nM (RIP1 kinase )[1]

In Vitro

GSK3145095 potently blocks the TNF response as shown by determination of overall cell viability as measured by cellular ATP levels (IC50 = 1.6 nM), cell death as measured by LDH release (IC50 = 0.5 nM) and RIP1-dependent inflammatory cytokine MIP-1β production, either as absolute levels for protein, or fold changes in mRNA expression (IC50 = 0.4 nM) [1].

Clinical Trial
Molecular Weight

397.38

Formula

C₂₀H₁₇F₂N₅O₂

CAS No.

1622849-43-7

SMILES

FC1=CC(F)=CC2=C1NC([[email protected]@H](NC(C3=NNC(CC4=CC=CC=C4)=N3)=O)CC2)=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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GSK3145095
Cat. No.:
HY-111946
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