1. Apoptosis
  2. RIP kinase
  3. GSK3145095

GSK3145095 

Cat. No.: HY-111946 Purity: 98.27% ee.: 99.94%
Handling Instructions

GSK3145095 is a RIP1 kinase inhibitor with an IC50 of 6.3 nM .

For research use only. We do not sell to patients.

GSK3145095 Chemical Structure

GSK3145095 Chemical Structure

CAS No. : 1622849-43-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 857 In-stock
Estimated Time of Arrival: December 31
1 mg USD 550 In-stock
Estimated Time of Arrival: December 31
5 mg USD 980 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1500 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
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Description

GSK3145095 is a RIP1 kinase inhibitor with an IC50 of 6.3 nM [1].

IC50 & Target

IC50: 6.3 nM (RIP1 kinase )[1]

In Vitro

GSK3145095 potently blocks the TNF response as shown by determination of overall cell viability as measured by cellular ATP levels (IC50 = 1.6 nM), cell death as measured by LDH release (IC50 = 0.5 nM) and RIP1-dependent inflammatory cytokine MIP-1β production, either as absolute levels for protein, or fold changes in mRNA expression (IC50 = 0.4 nM) [1].

Clinical Trial
Molecular Weight

397.38

Formula

C₂₀H₁₇F₂N₅O₂

CAS No.

1622849-43-7

SMILES

FC1=CC(F)=CC2=C1NC([[email protected]@H](NC(C3=NNC(CC4=CC=CC=C4)=N3)=O)CC2)=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (629.12 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5165 mL 12.5824 mL 25.1648 mL
5 mM 0.5033 mL 2.5165 mL 5.0330 mL
10 mM 0.2516 mL 1.2582 mL 2.5165 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.23 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (5.23 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.23 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 98.27% ee.: 99.94%

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GSK3145095
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HY-111946
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