H3R antagonist 5
H3R antagonist 5 (Compound 1b) is a selective histamine H3 receptor inverse agonist with a IC50 of 0.54 nM and the ability to cross the blood-brain barrier. H3R antagonist 5 can be used in central nervous system-related research.
For research use only. We do not sell to patients.
- CAS No.: 879368-27-1
- Formula: C23H32N2O4
- Molecular Weight:400.51
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Histamine Receptor Isoforms
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Biological Activity
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H3 receptor 0.54 nM (IC50) |
H1 Receptor >10 μM (IC50) |
H2 Receptor >10 μM (IC50) |
H4 receptor >10 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
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| HEK293 | IC50 |
>10000 nM
Compound: 1b
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Displacement of [35S]N-[(4R)-1'-[(2R)-6-cyano-1,2,3,4-tetrahydro-2-naphthalenyl]-3,4-dihydro-4-hydroxyspiro[2H-1-benzopyran-2,4'-piperidin]-6-yl]methanesulfonamide from human ERG in HEK293 cells
Displacement of [35S]N-[(4R)-1'-[(2R)-6-cyano-1,2,3,4-tetrahydro-2-naphthalenyl]-3,4-dihydro-4-hydroxyspiro[2H-1-benzopyran-2,4'-piperidin]-6-yl]methanesulfonamide from human ERG in HEK293 cells
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[PMID: 18768318] |
Chemical Information
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CAS No. 879368-27-1
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Molecular Weight 400.51
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Formula C23H32N2O4
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SMILES
COC1=CC=C2C(C(O[C@@]23CC[C@@H](C(N(CCN4CCCCC4)C)=O)CC3)=O)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
H3R antagonist 5 Related Classifications
HY-14517 Related Classifications
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