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Cat. No.: HY-146252

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hCAXII-IN-4

hCAXII-IN-4 (compound 5j) is a potent and selective CA XII inhibitor with an K_i value of 6.4 nM for human CA XII.

For research use only. We do not sell to patients.

CAS No.: 2414601-79-7
Formula: C₂₂H₂₇N₅O₆S
Molecular Weight:489.54

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

hCAXII-IN-4 Chemical Structure

CAS No.: 2414601-79-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

hCAXII-IN-4 (compound 5j) is a potent and selective CA XII inhibitor with an K_i value of 6.4 nM for human CA XII^[1].

IC₅₀ & Target

K_i: 129.8 nM (hCAI), 40.7 nM (hCAII), 45.3 nM (hCAIX), 6.4 nM (hCAXII)^[1]

All Carbonic Anhydrase Isoforms :

Chemical Information

CAS No. 2414601-79-7
Molecular Weight 489.54
Formula C₂₂H₂₇N₅O₆S
SMILES

O=C(NNC(NCC1=CC=C(OC)C=C1)=O)C2CCN(C(C3=CC=C(S(=O)(N)=O)C=C3)=O)CC2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Moi D, et al. Appliance of the piperidinyl-hydrazidoureido linker to benzenesulfonamide compounds: Synthesis, in vitro and in silico evaluation of potent carbonic anhydrase II, IX and XII inhibitors. Bioorg Chem. 2020 May;98:103728. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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hCAXII-IN-4

All Carbonic Anhydrase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

hCAXII-IN-4 Related Classifications

HY-146252 Related Classifications