2. Cell Cycle/DNA Damage Epigenetics
  3. HDAC
  4. HDAC6-IN-34

HDAC6-IN-34 (compound 21) is an oral active and selective HDAC6 inhibitor with the IC50 of 18 nM. HDAC6-IN-34 increases the acetylation level of tubulin without affecting histone acetylation in cutaneous T-cell lymphoma cells and inhibits TNF-α secretion in LPS (HY-D1056)-stimulated macrophage cells. HDAC6-IN-34 shows excellent anti-arthritic efficacy in rat.

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HDAC6-IN-34

HDAC6-IN-34 화학구조

CAS No. : 1432508-73-0

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제품 설명

HDAC6-IN-34 (compound 21) is an oral active and selective HDAC6 inhibitor with the IC50 of 18 nM. HDAC6-IN-34 increases the acetylation level of tubulin without affecting histone acetylation in cutaneous T-cell lymphoma cells and inhibits TNF-α secretion in LPS (HY-D1056)-stimulated macrophage cells. HDAC6-IN-34 shows excellent anti-arthritic efficacy in rat[1].

IC50 & Target

HDAC6

18 nM (IC50)

HDAC1

3.91 μM (IC50)

분자량

381.35

화학식

C18H18F3N3O3
CAS No.
SMILES

CC1(CC(C2=C(N(N=C2C(F)(F)F)CC3=CC=C(C=C3)C(NO)=O)C1)=O)C
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
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Keywords:

HDAC6-IN-341432508-73-0HDACHistone deacetylasesrat adjuvant-induced arthritis (AIA) modelLPS-stimulated macrophage cellsInhibitorinhibitorinhibit

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상품명:
HDAC6-IN-34
Cat. No.:
HY-163368
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